Results 51 to 60 of about 1,246,092 (314)

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Significance of Ischemic Heart Disease in Patients with Heart Failure and Preserved, Midrange, and Reduced Ejection Fraction : A Nationwide Cohort Study [PDF]

, 2017
Background - The pathogenic role of ischemic heart disease (IHD) in heart failure (HF) with reduced ejection fraction (HFrEF; EF
Lam, Carolyn S P, Benson, L, Braun, Oscar O.,, Ulf Dahlström, Koh, Angela S., Dahlstrom, U, Tay, Wan Ting,, Koh, Angela S.,, Tay, WT, Lund, LH, Savarese, G,, Benson, Lina, Lund, Lars H, Vedin, O, Benson, Lina,, Dahlstrom, Ulf,, Lund, Lars H.,, Tay, Wan Ting, Ola Vedin, Tiew Hwa Katherine Teng, Gianluigi Savarese, Dahlström, Ulf, Koh, AS, Oscar Ö. Braun, Lam, CSP, Braun, Oscar Ö., Savarese, Gianluigi, Lars H. Lund, Carolyn S.P. Lam, Teng, THK, Braun, OO, Teng, Tiew Hwa Katherine, Wan Ting Tay, Lam, Carolyn S. P.,, Vedin, Ola, Angela S. Koh, Teng, Tiew Hwa Katherine,, Vedin, Ola,, Savarese, Gianluigi,, Lina Benson   +39 more
core   +1 more source

Multiparity induces persistent myocardial structural, functional and transcriptomic remodelling in mice

Scientific Reports
Pregnancy poses unique hemodynamic and metabolic demands on the heart. Recent data suggests that a history of multiple pregnancies may be associated with a late-term increased risk of heart failure with preserved ejection fraction (HFpEF), however, the ...
Ruth R. Magaye, Bing H. Wang, Hongyi R. Liu, Shanae Bailey, Rithy Nuon, Sabrina Sutano, Michael Nyugen, Helen Kiriazis, Kyah Grigolon, Luchen Shan, William W. H. Ho, Fumihiko Takeuchi, Daniel G. Donner, David M. Kaye   +13 more
doaj   +1 more source

Consensus Standards and Recommendations for Developmental and Cognitive Surveillance, Screening, and Evaluation in Sickle Cell Disease: Executive Summary From the National Alliance of Sickle Cell Centers Neurocognitive Workgroup

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurodevelopmental and neurocognitive difficulties are prevalent among individuals with sickle cell disease and warrant prompt identification and support. This Special Report provides an executive summary of standards and recommendations for surveillance, screening, and evaluation for development and cognition across the lifespan developed by ...
Alyssa M. Schlenz, Donna Murdaugh, Andrew M. Heitzer, Jennifer N. Longoria, Wendy Santos‐Modesitt, Arianna Martin, Judy Cavazos, Jeff Schatz, Catherine R. Hoyt, Alison King, Eboni I. Lance, Steven Hardy, Marsha Treadwell   +12 more
wiley   +1 more source

Prognostic role of pulmonary arterial capacitance in advanced heart failure [PDF]

, 2012
Background-Right ventricular (RV) dysfunction frequently occurs and independently prognosticates in left-sided heart failure. It is not clear which RV afterload measure has the greatest impact on RV function and prognosis.
Taylor D.O., Skouri H.N., Dupont M., Starling R.C., Abrahams Z., Wu Y., Tang W.H.W., Mullens W.   +7 more
core   +1 more source

Single Center Experience With Impella 5.5 for Escalation and De-Escalation of Cardiogenic Shock Patients

Journal of Interventional Cardiology
Temporary mechanical circulatory support (tMCS) devices are a critical component for treating patients with cardiogenic shock (CS). We analyzed use of Impella 5.5 device for efficacy and safety in a single-center CS population from February 2022 and ...
Ioana Dumitru, Debbie Rinde-Hoffman, Maria Sevillano, Leeandra Schnell, Elizabeth Quintilliani, Swaroop Bommareddi   +5 more
doaj   +1 more source

Transient heart rate reduction improves acute decompensated heart failure‐induced left ventricular and coronary dysfunction

ESC Heart Failure, 2021
Aims Acute decompensated heart failure (ADHF), a live‐threatening complication of heart failure (HF), associates a further decrease of the already by HF‐impaired cardiac function with an increase in heart rate.
Nicolas Peschanski, Najah Harouki, Matthieu Soulie, Marianne Lachaux, Lionel Nicol, Isabelle Remy‐Jouet, Jean‐Paul Henry, Anais Dumesnil, Sylvanie Renet, Françoise Fougerousse, Ebba Brakenhielm, Antoine Ouvrard‐Pascaud, Christian Thuillez, Vincent Richard, Jérôme Roussel, Paul Mulder   +15 more
doaj   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

The brain in heart failure [PDF]

, 2004
After atrial fibrillation, heart failure is the second most frequent cardiac association of stroke. Deteriorating left ventricular systolic function appears to increase the risk of cardioembolic stroke in heart failure.
Pullicino, Patrick
core  

Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca2+-induced Ca2+ release in a rodent model of heart failure [PDF]

, 2012
Aims Ca2+-induced Ca2+ release (CICR) is critical for contraction in cardiomyocytes. The transverse (t)-tubule system guarantees the proximity of the triggers for Ca2+ release [L-type Ca2+ channel, dihydropyridine receptors (DHPRs)] and the sarcoplasmic ...
Terracciano, CM, Navaratnarajah, M, Dias, P, Moshkov, AV, Rao, C, Siedlecka, U, Gorelik, J, Ibrahim, M, Yacoub, MH   +8 more
core   +1 more source