Results 51 to 60 of about 2,859,907 (207)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Plasma urocortin 1 in human heart failure.

, 2009
The urocortins are emerging as potentially important contributors to neurohumoral regulation of the circulation with recent reports attributing a powerful array of hemodynamic, renal, and neurohumoral effects to the urocortins in cardiac failure.
Gamble, Gregory, Richards, AM, Yandle, TG, Wright, SP, Frampton, CM, Doughty, Robert   +5 more
core   +1 more source

Modifiable lifestyle factors and heart failure: A Mendelian randomization study

, 2020
Background: Lifestyle factors may be important targets in the prevention of heart failure. The current knowledge on the relationship between lifestyle factors and heart failure originates mostly from observational studies. The objective of this study was
Handoko, M. Louis, Beulens, Joline W. J.,, Oort, Sabine van,, Handoko, M. Louis,, Beulens, Joline W.J., van Ballegooijen, Adriana J., Larsson, Susanna C., Larsson, Susanna C.,, van Oort, Sabine, Ballegooijen, Adriana J. van,   +9 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database. [PDF]

, 2014
Heart failure is common in older people and its prevalence is increasing. The Heart 'omics' in AGEing (HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.
Rocca, Hans-Peter Brunner-La, Heymans, Stephane, Staessen, JA, Pocock, Stuart, Zannad, Faiez, Bauters, C, Brunner-La Rocca, Hans-Peter; id_orcid, Thijs, Lutgarde, Heymans, S, Cleland, J.G., Pocock, S, Staessen, Jan A., Mebazaa, A, Delles, C, Thijs, L, Masson, Serge, Bauters, Christophe, Kuznetsova, Tatiana, Tomaschitz, A, McDonald, K, Pinet, Florence, Collier, T, Mamas, Mamas, Pinet, F, Jacobs, Lotte, Mebazaa, Alexandre, Sever, P, Jin, Yu, Cleland, JG, Kuznetsova, T, Latini, Roberto, Rouet, P, Mamas, M, Cleland, John G F, Sever, Peter, Jin, Y, Latini, R, Delles, Christian, Rouet, Philippe, Brunner-La Rocca, Hans-Peter, Zannad, F, Brunner-La Rocca, HP, Jacobs, L, Pieske, Burket, Diez, Javier, Diez, J, Cleland, John GF, Masson, S, McDonald, Kenneth, Pieske, B, Staessen, Jan A, Cleland, John G.F., Rocca, HP, Collier, Timothy, Tomaschitz, Andreas, Pieske, Burkert   +55 more
core   +1 more source

Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications

Cardiovascular Diabetology
Background Although previous studies have evaluated renal function decline in patients with heart failure (HF), there is limited evidence on long-term renal trajectories, especially in patients with concomitant HF and type 2 diabetes (T2D).
Maria Teresa Julián, Pau Codina, Josep Lupón, Elisabet Zamora, Alejandra Pérez-Montes de Oca, Mar Domingo, Evelyn Santiago-Vacas, Andrea Borrellas, María Ruiz-Cueto, Carlos González-Gallego, Maribel Troya, Gregorio A. Romero-González, Nuria Alonso, Antoni Bayes-Genis   +13 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source