Results 71 to 80 of about 4,030,165 (305)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The brain in heart failure [PDF]

, 2004
After atrial fibrillation, heart failure is the second most frequent cardiac association of stroke. Deteriorating left ventricular systolic function appears to increase the risk of cardioembolic stroke in heart failure.
Pullicino, Patrick
core   +1 more source

Significance of Ischemic Heart Disease in Patients with Heart Failure and Preserved, Midrange, and Reduced Ejection Fraction : A Nationwide Cohort Study

, 2017
Background - The pathogenic role of ischemic heart disease (IHD) in heart failure (HF) with reduced ejection fraction (HFrEF; EF
Lam, Carolyn S P, Braun, Oscar O.,, Ulf Dahlström, Koh, Angela S., Dahlstrom, U, Tay, Wan Ting,, Koh, Angela S.,, Tay, WT, Lund, LH, Savarese, G,, Benson, Lina, Lund, Lars H, Vedin, O, Benson, Lina,, Lund, Lars H.,, Tay, Wan Ting, Ola Vedin, Tiew Hwa Katherine Teng, Gianluigi Savarese, Dahlström, Ulf, Koh, AS, Oscar Ö. Braun, Lam, CSP, Braun, Oscar Ö., Savarese, Gianluigi, Lars H. Lund, Carolyn S.P. Lam, Teng, THK, Braun, OO, Teng, Tiew Hwa Katherine, Wan Ting Tay, Lam, Carolyn S. P.,, Vedin, Ola, Angela S. Koh, Teng, Tiew Hwa Katherine,, Vedin, Ola,, Savarese, Gianluigi,, Lina Benson, Hwa Katherine Teng, Tiew,, Ting Tay, Wan,, Benson, L,, Lund, Lars H,, Dahlström, Ulf,, Lam, Carolyn S P,, Lund University.   +44 more
core   +1 more source

Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times? [PDF]

, 2009
Chronic heart failure increases the risk of atrial fibrillation (AF), with the prevalence of AF paralleling the severity of heart failure.1 Factors that underlie this increased susceptibility to AF may include electrical, structural, and neurohumoral ...
Rankin, A.C., Workman, A.J.
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The New Heart Failure Association Definition of Advanced Heart Failure [PDF]

, 2019
The clinical course of heart failure is characterised by progressive worsening of cardiac function and symptoms. Patients progress to a condition where traditional treatment is no longer effective and advanced therapies, such as mechanical circulatory ...
Elisabetta Dinatolo, Marco Metra, Nicolò Dasseni   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pre‐discharge and early post‐discharge management of patients hospitalized for acute heart failure: A scientific statement by the Heart Failure Association of the ESC

, 2023
Acute heart failure is a major cause of urgent hospitalizations. These are followed by marked increases in death and rehospitalization rates, which then decline exponentially though they remain higher than in patients without a recent hospitalization ...
Anker, SD, Abdelhamid, Magdy, Tomasoni, Daniela, Tomasoni, D, Bauersachs, J, Adamopoulos, Stamatis, Adamopoulos, S, Bayes‐Genis, Antoni, Adamo, M, Anker, Stefan D., Adamo, Marianna, Mebazaa, A, Abdelhamid, M, Bauersachs, Johann, Rosano, Giuseppe, Metra, M, Bayes-Genis, A, Mebazaa, Alexandre, Belenkov, Yuri, Belenkov, Y, Metra, Marco   +20 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Correction to: Low triiodothyronine syndrome and selenium deficiency - undervalued players in advanced heart failure? A single center pilot study

BMC Cardiovascular Disorders, 2019
After publication of the original article [1], the authors have notified us of a typing error in spelling Dr. Kabat’s name. The original publication has been corrected.
Magdalena Fraczek-Jucha, Katarzyna Zbierska-Rubinkiewicz, Małgorzata Kabat, Krzysztof Plens, Radoslaw Rychlak, Jadwiga Nessler, Andrzej Gackowski   +6 more
doaj   +1 more source