Results 81 to 90 of about 2,859,907 (207)

Compound Heterozygote Friedreich Ataxia Patients With Covert Proximal FXN Gene Deletions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present Friedreich ataxia patients with frataxin gene deletions. Data and records were collected at the Children's Hospital of Philadelphia from patients enrolled in the FACOMS natural history study. Patients with proximal deletions initially diagnosed with only one GAA expanded allele had more severe disease than their homozygous expansion
Michael P. Lazaropoulos, Morgan C. Devore, Christina Lam, Courtney Park, Sanjay Bidichandani, David R. Lynch   +5 more
wiley   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Prognostic role of pulmonary arterial capacitance in advanced heart failure

, 2012
Background-Right ventricular (RV) dysfunction frequently occurs and independently prognosticates in left-sided heart failure. It is not clear which RV afterload measure has the greatest impact on RV function and prognosis.
Taylor D.O., Skouri H.N., Dupont M., Starling R.C., Abrahams Z., Wu Y., Tang W.H.W., Mullens W.   +7 more
core   +1 more source

Integrated proteomic and metabolomic profiling reveals novel insights on the inflammation and immune response in HFpEF

BMC Genomics
Background The precise mechanisms leading to the development of heart failure with preserved ejection fraction (HFpEF) remain incompletely defined. In this study, an integrative approach utilizing untargeted proteomics and metabolomics was employed to ...
Muyashaer Abudurexiti, Refukaiti Abuduhalike, Tuersunjiang Naman, Nuerdun Wupuer, Dongqin Duan, Mayire Keranmu, Ailiman Mahemuti   +6 more
doaj   +1 more source

Correlation between mitochondrial DNA copy number, Klotho protein, myostatin and frailty in elderly patients with sarcopenia

Guoji laonian yixue zazhi
[Objective] To investigate the correlation of mitochondrial DNA copy number (mtDNAcn), Klotho protein, myostatin (MSTN) and their combination with physical frailty in elderly patients with sarcopenia.
Zhou Yanyan, Zhao Xulan, Zhang Shiyang, Xia Song, Zhang Junhui, Liang Fang   +5 more
doaj   +1 more source

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes, Leonardo Cruz‐Criollo, Eric Kontowicz, Marta Olivé‐Gadea, Francesco Diana, Johannes Kaesmacher, Adnan Mujanovic, Serdar Geyik, Songul Senadim, Amedeo Cervo, Andrea Salcuni, Mariangela Piano, Manuel Moreu, Alfonso López‐Frías, Ameer E. Hassan, Samantha Miller, Elena Zapata‐Arriaza, Asier de Albóniga‐Chindurza, Mauro Bergui, Stefano Molinaro, João André Sousa, Fábio Gomes, João Sargento‐Freitas, Andrea Alexandre, Alessandro Pedicelli, Jeremy Hofmeister, Paolo Machi, Luca Scarcia, Erwah Kalsoum, Jose Amorim, Torcato Meira, Leonardo Renieri, Francesco Capasso, Daniele Romano, Eduardo Bárcena‐Ruiz, David Seoane, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Catarina Perry da Câmara, Anderson Brito, Nashwa Abdelhakim, Isabel Fragata, Dileep R. Yavagal, Jude H. Charles, Jose Rodriguez Castro, Pedro Vega, Atilla Özcan Özdemir, Zehra Uysal Kocabaş, Stanislas Smajda, Sadiq Al Salman, Jane Khalife, Tudor G. Jovin, Francesco Biraschi, Francesca Richetti, Pedro Castro, Luis Albuquerque, Adnan Siddiqui, Vinay Jaikumar, Pedro Navia, Nikolaos Ntoulias, Marios Psychogios, Mariano Velo, Joaquín Zamarro, Gonzalo de Paco, Yazan Ashouri, Mohammad AlMajali, Juan F. Arenillas, Alicia Sierra, Michele Romoli, João Pedro Marto, Shadi Yaghi, Marc Ribo, Alejandro Tomasello, Manuel Requena, Santiago Ortega‐Gutierrez   +75 more
wiley   +1 more source

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology [PDF]

, 2017
There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF).
Lam, Carolyn S P, Thomas M. Gorter, Heymans, Stephane, Wachter, Rolf, Barry A. Borlaug, Hill, Loreena, Rutten, Frans H., Tschoepe, Carsten, Mitja Lainscak, Marisa G. Crespo-Leiro, Lainscak, Mitja, Andrew J.S. Coats, Solomon, Scott D., Shah, Sanjiv J, Paulus, Walter J, Scott D. Solomon, Lund, Lars H, Tschöpe, Carsten, Christian Mueller, Stephane Heymans, Bauersachs, Johann, Walter J. Paulus, Gorter, Thomas M., Harjola, Veli-Pekka, Lyon, Alexander R., Rutten, Frans H, Marco Guazzi, Harjola, Veli Pekka, Celutkiene, Jelena, Coats, Andrew J S, Gorter, Thomas M, Ruschitzka, Frank, Massimo F. Piepoli, Rudolf A. de Boer, Piepoli, Massimo F, Seferovic, Petar M, Lam, Carolyn S.P., de Boer, Rudolf A, Lars H. Lund, van Veldhuisen, Dirk J, Carolyn S.P. Lam, Seferovic, Petar M., Veli-Pekka Harjola, Lund, Lars H., Petar M. Seferovic, Alexander R. Lyon, Carsten Tschöpe, Rolf Wachter, Triposkiadis, Filippos, Dirk J. van Veldhuisen, Johann Bauersachs, Mebazaa, Alexandre, Piepoli, Massimo F., Lam, Carolyn SP, Lam, Carolyn S. P., Paulus, Walter J., Coats, Andrew J.S., Mueller, Christian, Frank Ruschitzka, de Boer, Rudolf A., Borlaug, Barry A, Hill, Loreena; id_orcid, Filippos Triposkiadis, Sanjiv J. Shah, Coats, Andrew JS, Solomon, Scott D, Frans H. Rutten, van Veldhuisen, Dirk J., Crespo-Leiro, Marisa G, Shah, Sanjiv J., Burkert Pieske, Alexandre Mebazaa, Coats, Andrew J. S., Jelena Celutkiene, Crespo-Leiro, Marisa G., Loreena Hill, Borlaug, Barry A., Lyon, Alexander R, Pieske, Burkert, Guazzi, Marco   +79 more
core   +3 more sources

Low triiodothyronine syndrome and selenium deficiency - undervalued players in advanced heart failure? A single center pilot study

BMC Cardiovascular Disorders, 2019
Background The function of deiodinases – selenoproteins converting thyroid hormones may be disturbed by oxidative stress accompanying heart failure. Selenium (Se) may be used by glutathione peroxidase, leading to a lack of deiodinase and triiodothyronine
Magdalena Fraczek-Jucha, Katarzyna Zbierska-Rubinkiewicz, Małgorzata Kabat, Krzysztof Plens, Radoslaw Rychlak, Jadwiga Nessler, Andrzej Gackowski   +6 more
doaj   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Significance of Ischemic Heart Disease in Patients with Heart Failure and Preserved, Midrange, and Reduced Ejection Fraction : A Nationwide Cohort Study

, 2017
Background - The pathogenic role of ischemic heart disease (IHD) in heart failure (HF) with reduced ejection fraction (HFrEF; EF
Lam, Carolyn S P, Benson, L, Braun, Oscar O.,, Ulf Dahlström, Koh, Angela S., Dahlstrom, U, Tay, Wan Ting,, Koh, Angela S.,, Tay, WT, Lund, LH, Savarese, G,, Benson, Lina, Lund, Lars H, Vedin, O, Benson, Lina,, Dahlstrom, Ulf,, Lund, Lars H.,, Tay, Wan Ting, Ola Vedin, Tiew Hwa Katherine Teng, Gianluigi Savarese, Dahlström, Ulf, Koh, AS, Oscar Ö. Braun, Lam, CSP, Braun, Oscar Ö., Savarese, Gianluigi, Lars H. Lund, Carolyn S.P. Lam, Teng, THK, Braun, OO, Teng, Tiew Hwa Katherine, Wan Ting Tay, Lam, Carolyn S. P.,, Vedin, Ola, Angela S. Koh, Teng, Tiew Hwa Katherine,, Vedin, Ola,, Savarese, Gianluigi,, Lina Benson   +39 more
core   +1 more source