Results 81 to 90 of about 4,030,165 (305)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Editors' highlight picks from 2023 in ESC heart failure [PDF]

Heart failure is a devastating syndrome affecting an increasingly high number of patients worldwide. Its aetiology and pathogenesis are complex with the involvement of factors ranging from the genetic material through valvular dysfunctions to numerous ...
Bäck, Magnus, Papp, Zoltán, Haehling, Stephan von, von Haehling, Stephan, Piepoli, Massimo, Piepoli, Massimo F., Piepoli, MF, Papp, Z, Back, M, von, Haehling S   +9 more
core   +1 more source

The genomics of heart failure: design and rationale of the HERMES consortium

, 2021
Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure.
Lin, H. H., Lindgren, C. M., Yang, J., Trompet, S., Lumbers, R. T., Holmes, M. V., Aragam, K. G., Zhao, F. Y., Samani, N. J., Nowak, C., Veluchamy, A., Helgadottir, A., Wiggins, K. L., Gudbjartsson, D. F., Kavousi, M., Langenberg, C., McMurray, J. J. V., Dorr, M., Visscher, P. M., Vaura, F., Cappola, T. P., Brandimarto, J., Cook, J. P., Hemingway, H., Roselli, C., Henry, A., Kardys, I., Melander, O., Perreault, L. P. L., Kuchenbaecker, K., Wells, Q. S., Teder-Laving, M., Morris, A. P., Salomaa, V., Hyde, C. L., Nagle, M. W., Vasan, R. S., Bloom, H. L., Malarstig, A., Khaw, K. T., Luan, J. A., Boersma, E., Chung, J. H., Sattar, N., Zannad, F., Ford, I., de Denus, S., Smelser, D. T., Asselbergs, F. W., Uitterlinden, A. G., Ruff, C. T., Verweij, N., Chazara, O., Kleber, M. E., Thorsteinsdottir, U., Felix, S. B., Fouodjio, R., Lovering, R. C., Rice, K. M., Almgren, P., Esko, T., Portilla-Fernandez, E., Dehghan, A., Kober, L., Taylor, K. D., Gross, S., Teumer, A., Margulies, K. B., Melloni, G., Marz, W., Dube, M. P., London, B., Doney, A. S., Arnlov, J., Mahajan, A., Morrison, A. C., Fatemifar, G., Volker, U., Wareham, N. J., Biggs, M. L., Carey, D. J., Gottdiener, J. S., Giulianini, F., Newton-Cheh, C., Gui, H. S., Tardif, J. C., Fougerousse, F., Denaxas, S., Thorgeirsson, G., Weeke, P. E., Morley, M. P., Smith, N. L., Wilk, J. B., Lotta, L. A., Tyl, B., Ellinor, P. T., Voors, A. A., Yerges-Armstrong, L. M., Ghasemi, S., Psaty, B. M., Sallah, N., Nelson, C. P., Sveinbjornsson, G., Mann, D., Smith, J. Gustav,, Chutkow, W., Hingorani, A. D., Andersson, C., Giedraitis, V., van Setten, J., Ghanbari, M., Kamanu, F., Mordi, I. R., Ridker, P. M., Romaine, S. P. R., Jukema, J. W., Torp-Pedersen, C., Sabatine, M. S., Finan, C., Haggerty, C. M., Morris, A. D., Owens, A. T., Yu, B., Dunn, M. E., Asselin, G., Chaffin, M. D., White, H. D., Perola, M., Lubitz, S. A., Rotter, J. I., Yang, Y. F., Stott, D. J., Weiss, R., Stender, S., van der Harst, P., Chen, X., Holm, H., Xing, H. M., Shalaby, A. A., Jacob, J., Tuckwell, D., Lang, C. C., Delgado, G. E., Shah, S., Hillege, H., O'Donoghue, M. L., Czuba, T., Palmer, C. N. A., Brown, M. R., Dudley, S. C., Stefansson, K., Lanfear, D. E., Chasman, D. I., Wang, X. S., Kraus, B., Niiranen, T., Cleland, J. G. F., Brunner-La Rocca, H. P., Marston, N. A., Tammesoo, M. L., Engstrom, G., Swerdlow, D. I., Koekemoer, A., Backman, J. D., Svensson, P., Magnusson, P., Pare, G., Salo, P., Lind, L., Niessner, A., Gutmann, R.   +170 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

A biomarker guided approach in heart failure [PDF]

, 2014
Heart failure is one of the commonest diagnoses presenting to physicians in the community or hospital care. Symptoms are often subjective, with clinicians having to rely on clinical assessment and radiological imaging to manage these patients.
Abela, Mark
core  

Prognostic Significance of Resting Heart Rate and Use of beta-Blockers in Atrial Fibrillation and Sinus Rhythm in Patients With Heart Failure and Reduced Ejection Fraction: Findings From the Swedish Heart Failure Registry

, 2015
BACKGROUND: In heart failure and reduced ejection fraction, the prognostic role of heart rate (HR) in atrial fibrillation (AF) is unknown and the effectiveness of beta-blockers has recently been questioned in AF.
Petzold, Max, Adiels, Martin,, Petzold, Max,, Sartipy, U., Adiels, Martin, Fu, Michael,, Lund, L. H., Fu, Michael, Dahlstrom, U., Li, S. J., Li, Shi-Jun,, Lund, Lars H.,, Dahlström, Ulf,, Sartipy, Ulrik,, Sartipy, U,, Dahlstrom, U, Petzold, M, Lund, LH, Adiels, M, Fu, M, Li, S-J   +20 more
core   +1 more source

Incidence and outcomes of cancer treatment-related cardiomyopathy among referrals for advanced heart failure

Cardio-Oncology, 2018
Background Approximately 2–3% of patients undergoing advanced heart failure therapies such as left ventricular assist devices (LVAD) and orthotropic heart transplantation (OHT) have chemotherapy-related cardiomyopathy, according to analyses of large ...
Raquel Araujo-Gutierrez, Sergio H. Ibarra-Cortez, Jerry D. Estep, Arvind Bhimaraj, Ashrith Guha, Imad Hussain, Myung H. Park, Guillermo Torre-Amione, Barry H. Trachtenberg   +8 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Heart Failure in Indonesia: A Growing Burden Beyond Conventional Care

Majalah Kardiologi Indonesia
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Vebiona Kartini Prima Putri, Siti Elkana Nauli, Anggia Chairuddin Lubis   +2 more
doaj   +1 more source