Results 61 to 70 of about 123,214 (256)

Origami‐Inspired Structural Design for Aquatic‐Terrestrial Amphibious Robots

Advanced Robotics Research, EarlyView.
This work presents a lightweight amphibious origami robot actuated by a single shape memory alloy wire. A rigid foldable origami structure with displacement amplification enables efficient terrestrial crawling and aquatic swimming. The addition of fan‐shaped units allows controllable turning in both environments.
Weiqi Liu, Chunlong Wang, Xiaohang Sun, Hongwei Guo, Jiayao Ma, Yan Chen   +5 more
wiley   +1 more source

Effect of aggressive diuresis in acute heart failure with reduced and preserved ejection fraction

ESC Heart Failure, 2021
Aims Heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) had distinct haemodynamic characteristics in the setting of acute heart failure.
Xin He, Bin Dong, Ruicong Xue, Jingjing Zhao, Zexuan Wu, Yuzhong Wu, Yuanyuan Zhou, Dexi Wu, Yugang Dong, Jiangui He, Chen Liu   +10 more
doaj   +1 more source

Optimization of Magnetic Milli‐Spinner for Robotic Endovascular Intervention

Advanced Robotics Research, EarlyView.
This work presents the design optimization of a multifunctional magnetic milli‐spinner for high‐speed propulsion and efficient clot debulking. The optimized design achieves an ultrafast swimming velocity of 55 cm/s (≈175 body lengths/s) in saline water, enabling stable upstream swimming against strong physiological flows and establishing magnetic milli‐
Lu Lu, Luca Higgins, Jack Bernardo, Ruike Renee Zhao   +3 more
wiley   +1 more source

Vericiguat in Heart Failure with Reduced Ejection Fraction [PDF]

New England Journal of Medicine, 2020
Paul W, Armstrong, Kevin J, Anstrom, Christopher M, O'Connor   +2 more
openaire   +4 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Real-world insights into empagliflozin use in heart failure across ejection fractions and patients with or without diabetes: a multicenter study from Bangladesh

BMC Endocrine Disorders
Background Empagliflozin, a member of the Sodium-Glucose Co-Transporter 2 (SGLT-2) inhibitor family, is a promising antidiabetic drug with proven benefits in heart failure (HF). However, its effects in heart failure patients in varying ejection fractions
Shahjada Selim, Md. Fakhrul Islam Khaled, Dipal Krishna Adhikary, Mir Jamal Uddin, Abdul Wadud Chowdhury, Saidur Rahman Khan, A. K. M. Monwarul Islam, Kazi Nazrul Islam, Sujoy Kumar Saha, Chayan Kumar Singha, Md. Abu Bakar Siddique, Chinmoy Saha, Suraiya Rahman Shova, Khondoker Md. Ferdoush Siraj, Syed E. Shaude, Sajal Krishna Banerjee   +15 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Impact of Obstructive Sleep Apnea in Patients with Acute Heart Failure: A Nationwide Cohort Study

Hearts
Background/Objectives: Heart failure presents a significant public health challenge, affecting millions in the US, with projections of increasing prevalence and economic burdens. Obstructive sleep apnea (OSA) is highly prevalent among HF patients.
Abdulmajeed Alharbi, Nahush Bansal, Anas Alsughayer, Momin Shah, Waleed Alruwaili, Mohammed Mhanna, Halah Alfatlawi, Eun Seo Kwak, Ayman Salih, Mohanad Qwaider, Ragheb Assaly   +10 more
doaj   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source