Results 71 to 80 of about 66,290,039 (265)

Combination therapy of midodrine and droxidopa for refractory hypotension in heart failure with preserved ejection fraction per a pharmacist’s proposal: a case report

Journal of Pharmaceutical Health Care and Sciences, 2021
Background Patients with chronic heart failure (CHF) are often treated using many diuretics for symptom relief; however, diuretic use may have to continue despite hypotension development in these patients.
Yuki Asai, Tomoaki Sato, Daisuke Kito, Takanori Yamamoto, Iwao Hioki, Yasuhisa Urata, Yasuharu Abe   +6 more
doaj   +1 more source

Collagen‐Based Gut‐on‐Chip for In Vitro Modeling of Intestinal Barrier Function and Host‐Pathogen Interactions

Advanced Materials Technologies, EarlyView.
A collagen‐based gut‐on‐chip model replicates the intestinal extracellular matrix, supporting villi‐like structures, tight junctions, and mucin production. This biomimetic platform enables rapid epithelial differentiation and functional barrier formation.
Fernanda López García, Jacques Leng, Hugo de Oliveira, Pierre Nassoy, Karine Dementhon   +4 more
wiley   +1 more source

From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure with Preserved Ejection Fraction Paradigm Revisited

, 2021
In accordance with the comorbidity-inflammation paradigm, comorbidities and especially metabolic comorbidities are presumed to drive development and severity of heart failure with preserved ejection fraction through a cascade of events ranging from ...
Paulus, Walter J., Zile, Michael R.
core   +1 more source

Origami‐Inspired Structural Design for Aquatic‐Terrestrial Amphibious Robots

Advanced Robotics Research, EarlyView.
This work presents a lightweight amphibious origami robot actuated by a single shape memory alloy wire. A rigid foldable origami structure with displacement amplification enables efficient terrestrial crawling and aquatic swimming. The addition of fan‐shaped units allows controllable turning in both environments.
Weiqi Liu, Chunlong Wang, Xiaohang Sun, Hongwei Guo, Jiayao Ma, Yan Chen   +5 more
wiley   +1 more source

Effect of aggressive diuresis in acute heart failure with reduced and preserved ejection fraction

ESC Heart Failure, 2021
Aims Heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) had distinct haemodynamic characteristics in the setting of acute heart failure.
Xin He, Bin Dong, Ruicong Xue, Jingjing Zhao, Zexuan Wu, Yuzhong Wu, Yuanyuan Zhou, Dexi Wu, Yugang Dong, Jiangui He, Chen Liu   +10 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Left atrial structural and mechanical remodelling in heart failure with reduced ejection fraction

, 2021
In patients with heart failure with reduced ejection fraction (HFrEF), an association between left atrial (LA) dilatation and dysfunction is expected, but the degree of coexistence of the two abnormalities and their relative prognostic role is not ...
Carluccio, Erberto, Giulia Elena Mandoli, Caterina Maffeis, Andrea Rossi, Nicola R. Pugliese, Mandoli, Giulia Elena, Frank L. Dini, Paolo Biagioli, Henein, Michael, Biagioli, Paolo, Erberto Carluccio, Pastore, Maria Concetta, Rossi, Andrea, Andreina D'Agostino, Anna Mengoni, Pedrinelli, Roberto, D'Agostino, Andreina, Inciardi, Riccardo M, Maffeis, Caterina, Mengoni, Anna, Cameli, Matteo, Andreina D’Agostino, Dini, Frank L, Maria Concetta Pastore, Michael Henein, Riccardo M. Inciardi, Pugliese, Nicola R, Matteo Cameli, Roberto Pedrinelli   +28 more
core   +1 more source

Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF [PDF]

, 2020
A central factor in the pathogenesis of heart failure (HF) with reduced ejection fraction is the initial decrease in systolic function. Prior attempts at increasing cardiac contractility with oral drugs have uniformly resulted in signals of increased ...
Legg, Jason C, Teerlink, John R., Kurtz, Christopher E, Varin, Claire, Malik, Fady I, McMurray, John J.V., Felker, G. Michael, Legg, Jason C., Kurtz, Christopher E., Malik, Fady I., Solomon, Scott D., Felker, G Michael, Teerlink, John R, Solomon, Scott D, Honarpour, Narimon, Büchele, Gustavo, Diaz, Rafael, McMurray, John J V, Metra, Marco   +18 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source