Results 231 to 240 of about 6,649,603 (308)

Quantitative Ultrasound Imaging and Artificial Intelligence in Neonatal Echocardiography: Methodological Advances, Reproducibility Challenges, and Computational Perspectives. [PDF]

J Imaging
Nikolaou AI, Chatzigiannis N, Kefala MA, Papaioannou E, Baltogianni M, Giaprou LE, Giapros V.   +6 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Effect of right- vs left-sided congenital diaphragmatic hernia and duration of tracheal occlusion on longitudinal lung-size changes. [PDF]

Ultrasound Obstet Gynecol
Watananirun K, Basurto D, Martinez-Portilla RJ, Gomez O, Vargas AMLF, Russo FM, De Catte L, Lewi L, Devlieger R, Peralta CFA, Gratacós E, Deprest J.   +11 more
europepmc   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Case Report: Shared decision-making in severe rheumatic mitral stenosis complicating pregnancy. [PDF]

Front Cardiovasc Med
Velásquez Trujillo LA, Hurtado Rivera MA, Bucheli Enríquez VR, Ayala Zapata S, Barbosa Balaguera S, Herrera Escandón ÁA.   +5 more
europepmc   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Multivariate Spectral Analysis of Transabdominally Recorded Intrauterine Acoustic Signals (TRIAS) Across Gestation. [PDF]

Sensors (Basel)
Tamaki R, Igarashi F, Yamamoto R, Asano H, Oku A, Akabane K, Noshiro K, Hosokawa A, Saito Y, Watari H, Umazume T.   +10 more
europepmc   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

A comparative analysis of fetal mirror-image dextrocardia in China pre- and post-COVID-19 lockdown lifting. [PDF]

BMC Pregnancy Childbirth
Xu W, Wei Y, Gao X, Yang X, Gao J, He S, Huo H, Qiao M, Dong X, Chen W, Zhao E, Liu B.   +11 more
europepmc   +1 more source

Investigating environmental heat exposure and its effects on maternal and fetal health in rural Northern Ghana (Physio-HeMAB Study): a study protocol for a cluster randomized trial. [PDF]

BMC Public Health
Zimmer RS, Yeboah E, Gomes LSDS, Fiebig L, Reyes AT, Hermann A, Kampim A, Nakpih CI, Horst A, Bergner M, Riemer M, Wallwiener S, Abiiro GA, Akazili J, Kantelhardt JW, Maggioni MA, De Allegri M, Azongo D, Kantelhardt EJ.   +18 more
europepmc   +1 more source