Results 71 to 80 of about 6,649,603 (308)

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

open access: yesAdvanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao   +10 more
wiley   +1 more source

Fetal growth, early life circumstances, and risk of suicide in late adulthood.

open access: yes, 2011
Recent studies in Sweden and Scotland have found early life conditions to be associated with increased risk of attempted and completed suicide in adolescence and young adulthood. It is not known, however, whether early life conditions affect suicide risk
Danziger, Phoebe Day   +8 more
core   +1 more source

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders [PDF]

open access: yes, 2011
Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and ...
Kooner, A.S.   +999 more
core   +2 more sources

The Influence of a Crosshair Visual Aid on Observer Detection of Simulated Fetal Heart Rate Signals

open access: yesAmerican Journal of Perinatology Reports, 2016
Objective To determine whether a visual aid overlaid on fetal heart rate (FHR) tracings increases detection of critical signals relative to images with no visual aid.
Rebecca A. Kennedy   +5 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

open access: yesAdvanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li   +9 more
wiley   +1 more source

Fetal bradycardia associated with left ventricle noncompaction diagnosed as HCN4 mutations

open access: yesAnnals of Pediatric Cardiology
A 35-year-old pregnant woman was referred to our hospital because of fetal bradycardia. Fetal echocardiography revealed a normal fetal heart except for slightly prominent trabeculae in the left ventricle, normal cardiac function, and fetal sinus ...
Kosuke Yonehara
doaj   +1 more source

Sawtooth fetal heart rate pattern associated with a favorable neurological outcome in an infant: a case report

open access: yesJournal of Medical Case Reports, 2019
Background The sawtooth fetal heart rate pattern is rare, and has been reported as a possible indicator of neurological sequelae in newborns. However, we observed this fetal heart rate pattern in an infant with normal neurological function.
Satoshi Ohira   +8 more
doaj   +1 more source

Current methods of non-invasive fetal heart rate surveillance

open access: yesClinical and Experimental Obstetrics & Gynecology, 2020
Introduction: As accurate fetal evaluation during labor is essential, there is a continuous need for better noninvasive ways of monitoring. Electronic fetal monitoring (EFM) is an essential tool towards effective fetal assessment during labor, with the ...
A. Theodoridou   +8 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

open access: yesAdvanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte   +21 more
wiley   +1 more source

Non-reassuring fetal heart rate and associated factors among laboring mothers at southern public hospitals in Ethiopia: a poisson regression model

open access: yesScientific Reports
Non-reassuring fetal heart rate is a critical indicator of fetal well-being. It is used to predict fetal hypoxia and metabolic acidosis due to insufficient fetal oxygenation and is the major contributor to perinatal mortality and morbidity.
Abeba Bishaw Asnake   +3 more
doaj   +1 more source

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