Results 1 to 10 of about 65,471 (356)

The Congenital Malformation of the Interatrial Septum—A Review of Its Development and Embryology with Clinical Implications [PDF]

Journal of Developmental Biology
The development process of the heart and cardiovascular system is fundamental in human development and highly regulated by genetic factors. This process needs to be highly regulated to prevent malformations.
Rui Caetano Oliveira, Paula Martins, Maria de Fátima Martins   +2 more
doaj   +2 more sources

DNA Methylation Levels of the TBX5 Gene Promoter Are Associated with Congenital Septal Defects in Mexican Paediatric Patients

Biology, 2022
The TBX5 gene regulates morphological changes during heart development, and it has been associated with epigenetic abnormalities observed in congenital heart defects (CHD).
Esbeidy García-Flores, José Manuel Rodríguez-Pérez, Verónica Marusa Borgonio-Cuadra, Gilberto Vargas-Alarcón, Juan Calderón-Colmenero, Juan Pablo Sandoval, José Antonio García-Montes, Víctor Manuel Espinoza-Gutiérrez, Juan Gerardo Reyes-García, Benny Giovanni Cazarín-Santos, Antonio Miranda-Duarte, Armando Gamboa-Domínguez, Nonanzit Pérez-Hernández   +12 more
doaj   +1 more source

Generation of a TBX5 homozygous knockout embryonic stem cell line (WAe009-A-45) by CRISPR/Cas9 genome editing

Stem Cell Research, 2021
Holt-Oram syndrome (HOS), which is caused by genetic changes in the TBX5 gene, affects the hands and heart. HOS patients have heart defects, including atrial septal defects (ASD), ventricular septal defects (VSD) and heart conduction disease.
Tiantian Zhao, Rui Bai, Fujian Wu, Wen-Jing Lu, Jun Zhang   +4 more
doaj   +1 more source

Partial ventricular septal defect (Pacman(R) Heart) [PDF]

European Journal of Echocardiography, 2008
Complete ventricular septal defects (VSD) can be congenital (estimated prevalence 0.5% in live births) (Roguin N, et al. High prevalence of muscular ventricular septal defect in neonates. J Am Coll Cardiol 1995;26:1545-1548) or may be a complication of acute myocardial infarction (estimated incidence in the era of thrombolysis 0.2%) [Crenshaw BS, et al.
Pujol, E, Morales, M, Roelandt, Jos, Perez, MJ, Masia, R, Sala, J, Geleijnse, Marcel   +6 more
openaire   +3 more sources

Cardiac troponin T is necessary for normal development in the embryonic chick heart [PDF]

, 2016
The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects.
England, Jennifer, Haig, Maria Isabel, Loughna, Siobhan, Pang, Kar Lai, Parnall, Matthew   +4 more
core   +4 more sources

Sox9 Expression in the Second Heart Field; A Morphological Assessment of the Importance to Cardiac Development with Emphasis on Atrioventricular Septation

Journal of Cardiovascular Development and Disease, 2022
Failure to form the septal structures that separate the left and right cardiac chambers results in defects that allow shunting of blood from one side of the heart to the other, leading to the mixing of oxygenated and de-oxygenated blood.
Raymond N. Deepe, Jenna R. Drummond, Renélyn A. Wolters, Emily A. Fitzgerald, Hannah G. Tarolli, Andrew B. Harvey, Andy Wessels   +6 more
doaj   +1 more source

Hypoxia Induced DNA Damage in Children with Isolated Septal Defect and Septal Defect with Great Vessel Anomaly of Heart [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background and Aim: In Congenital Heart Disease (CHD), shunting of blood occurs through the anatomical defects which lead to mixing of oxygenated and deoxygenated blood.
Vidya G., Suma H.Y., Vishnu Bhat B., Parkash Chand, Ramachandra Rao K.   +4 more
doaj   +1 more source

Evolution of surgery of ventricular septal defect closure [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022
A ventricular septal defect is one of the foremost prevalent congenital heart defects, accounting for around 20% of all congenital heart malformations.
Akkerbez Adilbekova, Shukhrat Marasulov, Bakhytzhan Nurkeyev, Saken Kozhakhmetov   +3 more
doaj   +1 more source

Automated image segmentation for cardiac septal defects based on contour region with convolutional neural networks: A preliminary study

Informatics in Medicine Unlocked, 2021
Echocardiogram examination is important for diagnosing cardiac septal defects. With the development of AI-based technology, an echocardiogram examination previously performed manually by cardiologists can be done automatically.
Ria Nova, Siti Nurmaini, Radiyati Umi Partan, Sukman Tulus Putra   +3 more
doaj   +1 more source

THE Epidemology of down’s syndrome among congential heart disease children in Faisalabad

European Journal of Volunteering and Community-Based Projects, 2021
Patients with Down’s syndrome are prone to have congenital heart defects. This study was conducted to evaluate the frequency of various congenital heart defects in children with Down’s syndrome.
Abdul Maajid Khokhar, Dr.Mohsin Muhammad Mohsin Ali, Sarwat Mahmood Mahmood, Muhammad Mazhar Fareed   +3 more
doaj   +2 more sources