Results 91 to 100 of about 1,706,419 (254)

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Successful Living-Donor Liver Transplant for Fulminant Hepatitis in a Heart Recipient

, 2017
Reactivation of hepatitis B virus replication is a known complication of immunosuppressive therapy, which can lead to hepatocellular injury, liver failure, and death.
Yang, Po-Chih;Ho, Cheng-Maw;Chou, Nai-Kuan;Wang, Shoei-Shen;Wu, Yao-Ming;Ho, Ming-Chih;Hu, Rey-Heng;Lee, Po-Huang, 胡瑞恒;周迺寬;何承懋;李伯皇;王水深;何明志;吳耀銘   +1 more
core   +1 more source

CMV Infection Following mRNA SARS-CoV-2 Vaccination in Solid Organ Transplant Recipients

Transplantation Direct, 2022
Shourjo Chakravorty, MD, Adam B. Cochrane, PharmD, MPH, Mitchell A. Psotka, MD, PhD, Anil Regmi, MD, Lauren Marinak, NP, Amy Thatcher, NP, Oksana A. Shlobin, MD, A. Whitney Brown, MD, Christopher S. King, MD, FCCP, Kareem Ahmad, MD, Vikramjit Khangoora, MD, Anju Singhal, MD, Steven D. Nathan, MD, FCCP, Shambhu Aryal, MD, FCCP   +13 more
doaj   +1 more source

Extended static preservation of donor lungs at 10°C and early post-transplant outcomes: Experience from a center in the US

JHLT Open
Introduction: An emerging body of evidence suggests that extended static preservation of donor lung allografts at 10°C yields clinical outcomes comparable to standard storage, while enabling transplantation to be performed in a semi-elective manner.
Yub Raj Sedhai, MD, Christopher S. King, MD, Silpa D. Kilaru, MD, Zein Kattih, MD, Adriana Kochi, MHA, Vikramjit Khangoora, MD, Jared D. Wilkinson, MD, Alan S. Nyquist, MD, Anju Singhal, MD, Junad M. Chowdhury, MD, Christopher A. Thomas, MD, Oksana A. Shlobin, MD, Steven D. Nathan, MD, Daniel Tang, MD, Shambhu Aryal, MD   +14 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Bioinspired Adaptive Surfaces for Intelligent Liquid Manipulation: Progressing From Passive and Active to Hybrid Strategies

Advanced Materials, EarlyView.
This review examines passive, active, and hybrid liquid manipulation strategies, highlighting hybrid approaches as an emerging route to reconcile energy efficiency with adaptive control. By actively reconstructing passive surfaces to store programmable interfacial energy, hybrid systems enable flexible yet low‐power liquid transport, with perspectives ...
Jiaqi Miao, Yiyuan Zhang, Liqiu Wang, Alan C. H. Tsang   +3 more
wiley   +1 more source

From Fiber Bundles to Architected Membranes: Triply Periodic Minimal Surface Architectures for Biohybrid Artificial Lungs

Advanced Materials, EarlyView.
Additively manufactured triply periodic minimal surface (TPMS) membranes offer an architecture‐driven alternative to hollow fiber bundles in artificial lungs. Multiphysics simulations and endothelialized prototypes show that the 3D‐printable membrane architecture improves gas exchange, blood flow distribution, and hemocompatibility, enabling ...
Michael Pflaum, Kai P. Barbian, Florian Neuhaus, Gerrit Sitarz, Carolin Nölke, Sebastian V. Jansen, John Linkhorst, Lukas T. Hirschwald, Sebastian Brosch, Christian Certa, Ulrich Steinseifer, Matthias Wessling, Jutta Arens, Arjang Ruhparwar, Bettina Wiegmann   +14 more
wiley   +1 more source

The potential clinical implications of slow vital capacity in patients with idiopathic pulmonary fibrosis

Respiratory Research
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with a highly variable clinical course. Forced vital capacity (FVC) is widely used as a marker of disease severity and progression, yet its variability and dependence on ...
Ho Cheol Kim, Sydney Guthrie, Christopher S. King, Shazia Khan, Christopher A. Thomas, Vikramjit Khangoora, Steven D. Nathan   +6 more
doaj   +1 more source

Interaction Between Frailty and Renal Function in Patients with Heart Failure

Life
Background. Frailty is highly prevalent among patients with heart failure (HF) and is associated with adverse clinical outcomes. Chronic kidney disease (CKD) frequently coexists with HF and may further increase risk. However, the clinical profile linking
Ángela Rodríguez-Eguren, José Jesús Broseta, Lydia Izquierdo, Joan Llevadot-Sesmilo, Eduard Solé Gonzalez, María Ángeles Castel, Juan José Rodriguez, Elena Cuadrado-Payán, Diana Rodriguez-Espinosa, Elena Sandoval, Aleix Cases, Francisco Maduell, Ana García-Álvarez, Marta Farrero, Pedro Caravaca-Pérez   +14 more
doaj   +1 more source