Results 71 to 80 of about 1,706,419 (254)

Comparison of continuous flow centrifugal left ventricular assist devices as a bridge to transplant strategy in a low organ donation environment: single center experience

Hellenic Journal of Cardiology
Objective: In patients with advanced heart failure, heart transplantation is currently the most effective treatment. However, in a low-organ donation environment, it is usually necessary to proceed in long-term mechanical circulatory support through left
Michael Bonios, Dimitris Miliopoulos, Angeliki Gkouziouta, Nektarios Kogerakis, Sokratis Fragkoulis, Iakovos Armenis, Dimitrios Zarkalis, Konstantinos Ieromonachos, Antigoni Koliopoulou, Evangelos Leontiadis, Panagiota Georgiadou, Vasiliki Vartela, Dimitrios Tsiapras, Petros Sfirakis, Christos Kapelios, Stavros Dimopoulos, Loukas Kaklamanis, Dimitrios Ntegiannis, Theofani Antoniou, Themistokles Chamogeorgakis, Stamatis Adamopoulos   +20 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Ex vivo lung perfusion and the Organ Care System: a review

Clinical Transplantation and Research
With the increasing prevalence of heart failure and end-stage lung disease, there is a sustained interest in expanding the donor pool to alleviate the thoracic organ shortage crisis.
Menander M, Sandeep Attawar, Mahesh BN, Owais Tisekar, Anoop Mohandas   +4 more
doaj   +1 more source

Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces

Advanced Functional Materials, EarlyView.
Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng, TzuChun Chung, Katpady Akhil Tantry, Siyu Wu, Jing Tian, Yunqi Cui, Lanyu Li, Yongzan Zhou, Zhilei Zhang, Zhe Su, Gaili Cao, Kun‐Wei Yeh, Ruipeng Li, Xianghui Xiao, Adam F. G. Leontowich, Yuan‐Yu Hsueh, Zhao Pan, Kam C. Tam, Badri Narayanan, Song Li, Yimin. A. Wu   +20 more
wiley   +1 more source

Ventricular assist devices as bridge to heart transplantation: impact on post-transplant infections.

, 2016
BACKGROUND Ventricular assist devices (VAD) are valuable options for patients with heart failure awaiting cardiac transplantation. We assessed the impact of pre-transplant VAD implantation on the incidence of post-transplant infections in a nationwide ...
Mueller, Nicolas J, Beldi, Guido, Ruschitzka, Frank, Kralidis, Georg, Wilhelm, Markus J, Manuel, Oriol, Swiss Transplant Cohort Study, STCS, Weisser, Maja, Hullin, Roger, Tozzi, Piergiorgio, Meylan, Pascal R, Mohacsi, Paul, van Delden, Christian, Carrel, Thierry, Héquet, Delphine, Garzoni, Christian, Stirnimann, Guido, Pascual, Manuel, Cusini, Alexia   +18 more
core   +1 more source

Efficacy and Safety of Empagliflozin in the Management of Diabetes Mellitus in Heart Transplant Recipients [PDF]

, 2019
Background. Type 2 diabetes mellitus (T2DM) is prevalent in patients undergoing heart transplant, and in those without preexisting T2DM, posttransplant diabetes mellitus may develop.
Muthiah, K, Greenfield, JR, Keogh, A, Hayward, C ; https://orcid.org/, Macdonald, PS ; https://orcid.org/, Cehic, MG, Jabbour, A, Hayward, C, Muir, CA, Macdonald, PS, Greenfield, JR ; https://orcid.org/, Kotlyar, E, Muir, CA ; https://orcid.org/   +12 more
core   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Early prescription of quadruple therapy in acute decompensated heart failure with reduced ejection fraction: A propensity score‐matched analysis

ESC Heart Failure
Aims The optimal timing for prescribing guideline‐directed medical therapy (GDMT) in patients with heart failure with reduced ejection fraction (HFrEF) during acute decompensated heart failure (ADHF) remains uncertain. This study evaluated the real‐world
Luis E. Echeverría, Lyda Z. Rojas, Angie Yarlady Serrano‐García, Daniel Botero, Karen Andrea García‐Rueda, Ángela Torres‐Bustamante, Diana Ivonne Cañón‐Gómez, Juan Sebastián Salcedo, Alexandra Hurtado‐Ortiz, Jaime A. Rodríguez, Sergio A. Gómez‐Ochoa   +10 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

The cost-effectiveness of left ventricular assist devices in end stage heart failure

, 2008
With a limited supply of donor hearts, individuals with end-stage heart failure have been offered hope through the use of mechanical devices. Left ventricular-assist devices (LVADs) are a technology designed to work in parallel with the heart but have ...
Bryant, Jackie, Colquitt, Jill L., Hutchinson, Julia, Loveman, Emma, Royle, Pam, Clegg, Andrew J., Scott, David A.   +6 more
core   +1 more source