Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco +2 more
wiley +1 more source
Oxidative Stress Related to Mechanical Heart Valves: A Pilot Cross-Sectional Study. [PDF]
Antioxidants (Basel)Palumbo IM +9 more
europepmc +1 more source
Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley +1 more source
Myval Octacor and Octapro T<i>rans</i>-Catheter Heart Valves in Patients with Severe Pure Non Calcified Native Aortic Regurgitation. [PDF]
Int J Cardiol Heart VascIelasi A +7 more
europepmc +1 more source
Refining a preclinical model of viral myocarditis in accordance with biotech standards
Animal Models and Experimental Medicine, EarlyView.This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen +9 more
wiley +1 more source
Mechanotransduction of autotransplants: remodeling potential of heart valves from autologous pericardial tissue. [PDF]
Front Bioeng BiotechnolSteitz M +6 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou +4 more
wiley +1 more source
Innovation and Development in Polymer Heart Valves: A New Era of Transcatheter Aortic Valve Replacement. [PDF]
Eur CardiolMao Y +5 more
europepmc +1 more source
Methacrylated Gelatin and Graphene Oxide Hybrid Hydrogels Composed‐Bioinks for 3D Tissue Engineering
Advanced NanoBiomed Research, EarlyView.Bioinks made from hydrogels, such as methacrylated gelatin (GelMA), serve as the base material for bioprinted tissues, offering versatility and biocompatibility for a range of applications. Additional components however are still needed to improve functionality and mechanical stability of hydrogels. One of these components is graphene oxide (GO), added
Wanessa S. Mota +10 more
wiley +1 more source
A novel approach to flow visualization through mechanical heart valves. [PDF]
Proc Inst Mech Eng HGoode D +4 more
europepmc +1 more source