Results 31 to 40 of about 119,279 (238)

Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction

Advanced Materials, EarlyView.
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang, Zilu Xu, Feiyang Zheng, Dongcheng Yang, Kaige Xu, Ming Ke, Xiao Zhou, Xiaohan Zhang, Ju Tan, Yong Liu, Yansha Hao, Malcolm Xing, Chuhong Zhu   +12 more
wiley   +1 more source

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. [PDF]

, 2018
RationaleMutations in the transcription factor TBX20 (T-box 20) are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and embryonic lethality by embryonic day 9.5.
Aneas, Ivy, Bogomolovas, Julius, Boogerd, Cornelis J, Chen, Ju, Evans, Sylvia M, Joslin, Amelia C, Montefiori, Lindsey, Nobrega, Marcelo A, Sakabe, Noboru, Sobreira, Debora R, Zhang, Lunfeng, Zhou, Bin, Zhu, Xiaoming   +12 more
core   +2 more sources

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source

A tissue-engineered scale model of the heart ventricle [PDF]

Nature Biomedical Engineering, 2018
Laboratory studies of the heart use cell and tissue cultures to dissect heart function yet rely on animal models to measure pressure and volume dynamics. Here, we report tissue-engineered scale models of the human left ventricle, made of nanofibrous scaffolds that promote native-like anisotropic myocardial tissue genesis and chamber-level contractile ...
John F. Zimmerman, John F. Zimmerman, Christophe O. Chantre, Christophe O. Chantre, Xujie Liu, Andrew K. Capulli, Andrew K. Capulli, Josue A. Goss, Josue A. Goss, Luke A. MacQueen, Luke A. MacQueen, Sean P. Sheehy, Sean P. Sheehy, Lakshminarayanan Mahadevan, Patrick H. Campbell, Patrick H. Campbell, Kevin Kit Parker, Kevin Kit Parker, Sung-Jin Park, Sung-Jin Park, William T. Pu, William T. Pu, T. Fettah Kosar, John P. Ferrier, John P. Ferrier, Grant M. Gonzalez, Grant M. Gonzalez, Francesco S. Pasqualini, Francesco S. Pasqualini   +28 more
openaire   +3 more sources

Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction

Advanced Materials, EarlyView.
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Madeline P. Hopps, JoJo J. Holm, Quincy P. Lyons, Michael B. Nguyen, Jervaughn D. Hunter, Assa Magassa, Elyse G. Wong, Kate Reimold, Sriya N. Paleti, Emily Gardner, Matthew P. Thompson, Colin G. Luo, Xiaoyu Zhang, Karen L. Christman, Nathan C. Gianneschi   +17 more
wiley   +1 more source

Myocardial infarction in a patient with a single ventricle of the heart

Kardiologiia, 2021
A clinical case of myocardial infarction in a patient with single ventricle heart defect is described. 
O. M. Polikutina, Yu. S. Slepynina, A. V. Ivanova, I. N. Taran, S. A. Shmulevich, N. G. Perevalova   +5 more
openaire   +3 more sources

The failing heart under stress: echocardiography is an essential monitoring tool in the Intensive Care Unit [PDF]

, 2006
A
Poelaert, Jan
core   +2 more sources

Inorganic Dielectric Materials Coupling Micro‐/Nanoarchitectures for State‐of‐the‐Art Biomechanical‐to‐Electrical Energy Conversion Devices

Advanced Materials, EarlyView.
Biomechanical‐to‐electrical energy conversion devices are uniquely suited for self‐driven physiological information monitoring and powering human–computer interaction systems. These devices based on micro‐/nanoarchitectured inorganic dielectric materials (MNIDMs) have shown ultrahigh electromechanical performance and thus great potential for practical ...
Jia‐Han Zhang, Zhengtong Li, Zeng Liu, Mingxuan Li, Jiaxin Guo, Jinhua Du, Changkun Cai, Shaohui Zhang, Ningning Sun, Yong Li, Xingtao Xu, Xihong Hao, Yusuke Yamauchi   +12 more
wiley   +1 more source

How to read the equine electrocardiogram? : tips and tricks [PDF]

, 2011
C
van Loon, Gunther
core   +1 more source

C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation [PDF]

, 2017
International audienceVoltage-gated Na(+) (NaV) channels are key regulators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in NaV1.5 channel inactivation are emerging as a critical determinant
Brown, Joan H., Burel, Sophie, Charpentier, Flavien, Coyan, Fabien C., Lichti, Cheryl F., Lorenzini, Maxime, Loussouarn, Gildas, Maier, Lars S., Marionneau, Celine, Meyer, Matthew R., Nerbonne, Jeanne M., Townsend, R. Reid   +11 more
core   +2 more sources