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Overlap of functional heartburn and reflux hypersensitivity with proven gastroesophageal reflux disease

Neurogastroenterology and Motility, 2020
When esophageal acid exposure time (AET) is physiologic, ROME IV stratifies functional esophageal disorders into functional heartburn (FH, with negative reflux‐symptom association) and reflux hypersensitivity (RH, with positive reflux‐symptom association)
A. Rengarajan   +3 more
semanticscholar   +1 more source

Mechanisms of heartburn

Nature Clinical Practice Gastroenterology & Hepatology, 2008
Heartburn is a typical symptom of GERD. The spectrum of diseases associated with GERD includes reflux esophagitis, Barrett's esophagus and nonerosive reflux disease (NERD). Although acid reflux is the classic cause of heartburn in patients with erosive esophagitis, the relationship between acid and heartburn is far from clear, especially in patients ...
Daphne, Ang, Daniel, Sifrim, Jan, Tack
openaire   +2 more sources

New York clinical trial quietly tests heartburn remedy against coronavirus

, 2020
The fast-growing list of possible treatments for the novel coronavirus includes an unlikely candidate: famotidine, the active compound in the over-the-counter heartburn drug Pepcid On 7 April, the first COVID-19 patients at Northwell Health in the New ...
B. Borrell
semanticscholar   +1 more source

Diet and Heartburn

JAMA: The Journal of the American Medical Association, 1979
SYMPTOMATIC gastroesophageal reflux (heartburn) is a ubiquitous postprandial complaint. Although usually a recurring complaint, it can be transient (as in the third trimester of pregnancy) or persistent and progressive (as in progressive systemic sclerosis).
B, Chernow, D O, Castell
openaire   +2 more sources

Heartburn in pregnancy

The American Journal of Digestive Diseases, 1962
Half of pregnant women have heartburn during pregnancy. Most primaparas and some multiparas are spontaneously relieved in the last weeks as the uterus descends, but all are invariably relieved immediately after delivery. The heartburn is a newly experienced burning sensation of variable severity in the throat or substernal region, frequently radiating ...
R, NAGLER, H M, SPIRO
openaire   +2 more sources

Functional heartburn

Current Treatment Options in Gastroenterology, 2005
Functional heartburn (FH) is a common disorder that accounts for 30% to 50% of the patients with nonerosive reflux disease. FH is composed from a heterogeneous group of patients. They primarily include the hypersensitive and the nonacid sensitive esophagus.
Ram, Dickman, Ronnie, Fass
openaire   +2 more sources

Functional heartburn

Current Treatment Options in Gastroenterology, 2002
Functional heartburn is defined as the presence of a retrosternal burning sensation in the absence of pathologic gastroesophageal reflux. The underlying pathophysiology seems to be heterogeneous. In a subset of patients, esophageal hypersensitivity to physiologic esophageal acid exposure is involved, and this is likely to respond to intensive ...
Jan, Tack, Jozef, Janssens
openaire   +2 more sources

Stress and heartburn

Journal of Psychosomatic Research, 2005
The majority of heartburn sufferers believe that stress exacerbates their heartburn [1]. This perception is supported by a recent study that documented that the presence of a severe sustained life stress in the previous 6 months predicted increased heartburn in the succeeding months [2].
openaire   +2 more sources

Heartburn

JAMA, 1976
There is currently controversy as to the importance of the radiologic demonstration of a hiatal hernia, reflux, or both as the explanation of heartburn. It is clear, however, that clinical-radiologic correlation requires additional observations such as the straightness of the potential path for reflux, the presence of a contractile esophagogastric ...
openaire   +2 more sources

Determinants of pregnancy heartburn

BJOG: An International Journal of Obstetrics & Gynaecology, 1992
ABSTRACTObjective To study the prevalence and severity of reflux symptoms in pregnancy.Design Self‐administered questionnaire detailing age, race, gestational age, parity, weight, height, symptoms and severity of gastro‐oesophageal reflux.Setting An antenatal clinic in a teaching hospital.Subjects 607 consecutive women at ...
J M, Marrero   +4 more
openaire   +2 more sources

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