Results 31 to 40 of about 1,665,249 (121)

Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction. [PDF]

J Biol Chem, 2017
Heartland virus (HRTV) is a pathogenic phlebovirus related to the severe fever with thrombocytopenia syndrome virus (SFTSV), another phlebovirus causing life-threatening disease in humans.
Ning YJ, Feng K, Min YQ, Deng F, Hu Z, Wang H.   +5 more
europepmc   +4 more sources

First detection of heartland virus (Bunyaviridae: Phlebovirus) from field collected arthropods. [PDF]

Am J Trop Med Hyg, 2013
Heartland virus (HRTV), the first pathogenic Phlebovirus (Family: Bunyaviridae) discovered in the United States, was recently described from two Missouri farmers. In 2012, we collected 56,428 ticks representing three species at 12 sites including both patients' farms.
Savage HM, Godsey MS, Lambert A, Panella NA, Burkhalter KL, Harmon JR, Lash RR, Ashley DC, Nicholson WL.   +8 more
europepmc   +7 more sources

Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1. [PDF]

J Biol Chem, 2019
Heartland virus (HRTV) is a pathogenic phlebovirus recently identified in the United States and related to severe fever with thrombocytopenia syndrome virus (SFTSV) emerging in Asia.
Feng K, Deng F, Hu Z, Wang H, Ning YJ.
europepmc   +4 more sources

Serological investigation of heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013. [PDF]

Am J Trop Med Hyg, 2015
Heartland virus (HRTV; Bunyaviridae: Phlebovirus) has recently emerged as a causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States.
Bosco-Lauth AM, Panella NA, Root JJ, Gidlewski T, Lash RR, Harmon JR, Burkhalter KL, Godsey MS, Savage HM, Nicholson WL, Komar N, Brault AC.   +11 more
europepmc   +4 more sources

Development of diagnostic microsphere-based immunoassays for Heartland virus.

Journal of Clinical Virology, 2020
Heartland virus (HRTV), a recently reclassified member of the genus Bandavirus, family Phenuiviridae, was first isolated in 2009 from a Missouri farmer exhibiting leukopenia and thrombocytopenia with suspected ehrlichiosis. Since then, more HRTV cases have been diagnosed, and firstline laboratory diagnostic assays are needed to identify future ...
A. Basile, Kalanthe A Horiuchi, Christin H. Goodman, O. Kosoy, Amanda J. Panella, J. Velez, Daniel M. Pastula, A. Brault, J. E. Staples, A. E. Calvert   +9 more
semanticscholar   +5 more sources

Characterization of pseudotyped vesicular stomatitis virus bearing the heartland virus envelope glycoprotein.

Virology, 2020
The heartland virus (HRTV) is a novel phlebovirus that causes severe infections in the USA and closely related to the severe fever thrombocytopenia syndrome virus (SFTSV), a causative agent for SFTS in Asia. The entry mechanisms of HRTV remain unclear.
Miyuki Kimura, Kazutaka Egawa, Tatsuhiko Ozawa, H. Kishi, M. Shimojima, S. Taniguchi, S. Fukushi, Hikaru Fujii, Hiroshi Yamada, L. Tan, K. Sano, H. Katano, Tadaki Suzuki, S. Morikawa, M. Saijo, H. Tani   +15 more
semanticscholar   +5 more sources

Transmission of Heartland Virus (Bunyaviridae: Phlebovirus) by Experimentally Infected Amblyomma americanum (Acari: Ixodidae) [PDF]

Journal of Medical Entomology, 2016
Heartland virus (HRTV; Bunyaviridae: Phlebovirus) is a recently described cause of human illness in the United States. After field studies conducted in 2012 implicated Amblyomma americanum (L.) as a vector of HRTV, we initiated experiments to assess the vector competence of A. americanum.
M. Godsey, H. M. Savage, Kristen L. Burkhalter, A. Bosco-Lauth, M. Delorey   +4 more
semanticscholar   +5 more sources

Focal persistence and phylodynamics of Heartland virus in Georgia

bioRxiv
Heartland virus (HRTV) is an emerging tick-bone virus associated with severe illness in the U.S. There are large gaps in knowledge of HRTV diversity, evolution, and transmission due to a paucity of HRTV-positive samples and genome sequences.
Stephanie Bellman, Nima Shariatzadeh, Tyshawn Ferrell, Audrey Long, Leah Aeschleman, Ellie Fausett, Tim Walsh, Seana Cleary, Isabella Roeske, Erick Ojeda, Madison Schwab, Hannah Dakanay, Sam R Telford, H. Goethert, Gonzalo M. Vazquez-Prokopec, A. Piantadosi   +15 more
semanticscholar   +3 more sources

Malsoor virus, a novel bat phlebovirus, is closely related to severe fever with thrombocytopenia syndrome virus and heartland virus. [PDF]

J Virol, 2014
ABSTRACT During a survey in the year 2010, a novel phlebovirus was isolated from the Rousettus leschenaultii species of bats in western India. The virus was identified by electron microscopy from infected Vero E6 cells.
Mourya DT, Yadav PD, Basu A, Shete A, Patil DY, Zawar D, Majumdar TD, Kokate P, Sarkale P, Raut CG, Jadhav SM.   +10 more
europepmc   +8 more sources

Widespread Circulation of Tick-Borne Viruses in Virginia—Evidence of Exposure to Heartland, Bourbon, and Powassan Viruses in Wildlife and Livestock [PDF]

Microorganisms
Emerging tick-borne viruses such as Powassan virus (POWV), Bourbon virus (BRBV), and Heartland virus (HRTV), whilst rare, can cause severe health problems in humans.
Ahmed Garba, Jennifer Riley, Kevin K. Lahmers, Gillian Eastwood   +3 more
doaj   +4 more sources