Results 21 to 30 of about 7,524 (166)

Modeling Heartland virus disease in mice and therapeutic intervention with 4′-fluorouridine [PDF]

Journal of Virology
ABSTRACT Heartland virus (HRTV) is an emerging tick-borne bandavirus that causes a febrile illness of varying severity in humans, with cases reported in eastern and midwestern regions of the United States. No vaccines or approved therapies are available to prevent or treat HRTV disease.
Craig Martens, Aaron J Thomas, Manohar T Saindane   +2 more
exaly   +4 more sources

The Lone Star tick, Amblyomma americanum, salivary factors exacerbate the clinical outcome of Heartland virus disease in a small animal model [PDF]

Scientific Reports, 2023
Heartland virus was first isolated in 2009 from two patients in Missouri and is transmitted by the Lone Star tick, Amblyomma americanum. To understand disease transmission and pathogenesis, it is necessary to develop an animal model which utilizes the ...
Erin S. Reynolds, Jacob T. Wooldridge, Heather L. Stevenson, Saravanan Thangamani   +3 more
doaj   +2 more sources

The Postfusion Structure of the Heartland Virus Gc Glycoprotein Supports Taxonomic Separation of the Bunyaviral Families Phenuiviridae and Hantaviridae [PDF]

Journal of Virology, 2018
ABSTRACT Heartland virus (HRTV) is an emerging human pathogen that belongs to the newly defined family Phenuiviridae , order Bunyavirales . Gn and Gc are two viral surface glycoproteins encoded by the M segment and are required for early events during infection.
Yan Chai, Jianxun Qi, Ruchao Peng
exaly   +5 more sources

Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins [PDF]

mSphere, 2017
In recent years, several newly discovered tick-borne viruses causing a wide spectrum of diseases in humans have been ascribed to the Phlebovirus genus of the Bunyaviridae family.
Veronica V. Rezelj, Ping Li, Vidyanath Chaudhary, Richard M. Elliott, Dong-Yan Jin, Benjamin Brennan   +5 more
doaj   +5 more sources

Secondary hemophagocytic lymphohistiocytosis due to Heartland virus. [PDF]

BMJ Case Rep, 2022
An older man from the mid-Southeastern USA presented with acute onset of fever, fatigue, and non-bloody diarrhoea. There was high suspicion for tick-borne illness given exposure history, clinical presentation and laboratory abnormalities. Despite prompt treatment with doxycycline, the patient clinically worsened.
Ahlers CG, Matthews H, Perez R, Naggie S.   +3 more
europepmc   +3 more sources

Safety, Immunogenicity, and Efficacy of a Recombinant Vesicular Stomatitis Virus Vectored Vaccine Against Severe Fever with Thrombocytopenia Syndrome Virus and Heartland Bandavirus

Vaccines
Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a recently emerged tickborne virus in east Asia with over 18,000 confirmed cases.
Philip Hicks, Tomaz B. Manzoni, Jonna B. Westover, Raegan J. Petch, Brianne Roper, Brian B. Gowen, Paul Bates   +6 more
doaj   +4 more sources

Focal persistence and phylodynamics of Heartland virus in Georgia. [PDF]

Virus Evol
Abstract Heartland virus (HRTV) is an emerging tick-borne virus associated with severe illness in the USA. There are large gaps in knowledge of HRTV diversity, evolution, and transmission due to a paucity of HRTV-positive samples and genome sequences.
Bellman S, Shariatzadeh N, Ferrell T, Long A, Aeschleman L, Fausett E, Walsh T, Cleary S, Roeske I, Ojeda E, Schwab M, Dakanay H, Telford Iii SR, Goethert HK, Vazquez-Prokopec G, Piantadosi A.   +15 more
europepmc   +3 more sources

Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA

Ticks and Tick-Borne Diseases, 2023
Heartland and Bourbon viruses are pathogenic tick-borne viruses putatively transmitted by Amblyomma americanum, an abundant tick species in Missouri. To assess the prevalence of these viruses in ticks, we collected 2778 ticks from eight sampling sites at
Ishmael D. Aziati, Derek McFarland Jnr, Avan Antia, Astha Joshi, Anahi Aviles-Gamboa, Preston Lee, Houda Harastani, David Wang, Solny A. Adalsteinsson, Adrianus C.M. Boon   +9 more
doaj   +1 more source

Novel Clinical and Pathologic Findings in a Heartland Virus-Associated Death. [PDF]

Clin Infect Dis, 2017
Abstract We describe an investigation into a Heartland virus (HRTV)–associated death in Tennessee with novel clinical and pathologic findings. HRTV can cause rapidly fatal, widely disseminated infection with multisystem organ failure in patients without substantial comorbidities.
Fill MA, Compton ML, McDonald EC, Moncayo AC, Dunn JR, Schaffner W, Bhatnagar J, Zaki SR, Jones TF, Shieh WJ.   +9 more
europepmc   +4 more sources

Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir [PDF]

Virology, 2017
Jinxin Miao, Yousuke Furuta, Saravanan Thangamani   +2 more
exaly   +2 more sources