Results 61 to 70 of about 1,665,249 (121)

The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target

Cell Reports, 2020
Summary: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Wenjie Wang, Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji-Seung Yoo, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman, Michael L. Gross, Daisy W. Leung, Jae U. Jung, Gaya K. Amarasinghe   +11 more
doaj  

Susceptibility of Type I Interferon Receptor Knock-Out Mice to Heartland Bandavirus (HRTV) Infection and Efficacy of Favipiravir and Ribavirin in the Treatment of the Mice Infected with HRTV

Viruses, 2022
Heartland bandavirus (HRTV) is an emerging tick-borne virus that is distributed in the United States and that causes febrile illness with thrombocytopenia and leukocytopenia.
Hikaru Fujii, Hideki Tani, Kazutaka Egawa, Satoshi Taniguchi, Tomoki Yoshikawa, Shuetsu Fukushi, Souichi Yamada, Shizuko Harada, Takeshi Kurosu, Masayuki Shimojima, Takahiro Maeki, Chang-Kweng Lim, Mutsuyo Takayama-Ito, Takashi Komeno, Nozomi Nakajima, Yousuke Furuta, Akihiko Uda, Shigeru Morikawa, Masayuki Saijo   +18 more
doaj   +1 more source

The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus

mSphere, 2018
The recent emergence of novel tick-borne RNA viruses has complicated the epidemiological landscape of tick-borne infectious diseases, posing a significant challenge to public health systems that seek to counteract tick-borne diseases.
Keita Matsuno, Masahiro Kajihara, Ryo Nakao, Naganori Nao, Akina Mori-Kajihara, Mieko Muramatsu, Yongjin Qiu, Shiho Torii, Manabu Igarashi, Nodoka Kasajima, Keita Mizuma, Kentaro Yoshii, Hirofumi Sawa, Chihiro Sugimoto, Ayato Takada, Hideki Ebihara   +15 more
doaj   +1 more source

Immune Modulation and Immune-Mediated Pathogenesis of Emerging Tickborne Banyangviruses

Vaccines, 2019
In the last decade, the emergence of several, novel tickborne viruses have caused significant disease in humans. Of interest are the tickborne banyangviruses: Severe fever with thrombocytopenia syndrome virus (SFTSV), Heartland virus (HRTV), and Guertu ...
Crystal A. Mendoza, Hideki Ebihara, Satoko Yamaoka   +2 more
doaj   +1 more source

Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases

BMC Medicine, 2022
Background The severe fever with thrombocytopenia syndrome disease (SFTS), caused by the novel tick-borne SFTS virus (SFTSV), was listed among the top 10 priority infectious disease by World Health Organization due to the high fatality rate of 5–30% and ...
Shu Shen, Yaxian Zhang, Zhiyun Yin, Qiong Zhu, Jingyuan Zhang, Tiantian Wang, Yaohui Fang, Xiaoli Wu, Yuan Bai, Shiyu Dai, Xijia Liu, Jiayin Jin, Shuang Tang, Jia Liu, Manli Wang, Yu Guo, Fei Deng   +16 more
doaj   +1 more source

Cell Culture and Electron Microscopy for Identifying Viruses in Diseases of Unknown Cause

Emerging Infectious Diseases, 2013
During outbreaks of infectious diseases or in cases of severely ill patients, it is imperative to identify the causative agent. This report describes several events in which virus isolation and identification by electron microscopy were critical to ...
Cynthia S. Goldsmith, Thomas G. Ksiazek, Pierre E. Rollin, James A. Comer, William L. Nicholson, Teresa C.T. Peret, Dean D. Erdman, William J. Bellini, Brian H. Harcourt, Paul A. Rota, Julu Bhatnagar, Michael D. Bowen, Bobbie R. Erickson, Laura K. McMullan, Stuart T. Nichol, Wun-Ju Shieh, Christopher D. Paddock, Sherif R. Zaki   +17 more
doaj   +1 more source

The genome sequence of Lone Star virus, a highly divergent bunyavirus found in the Amblyomma americanum tick. [PDF]

PLoS ONE, 2013
Viruses in the family Bunyaviridae infect a wide range of plant, insect, and animal hosts. Tick-borne bunyaviruses in the Phlebovirus genus, including Severe Fever with Thrombocytopenia Syndrome virus (SFTSV) in China, Heartland virus (HRTV) in the ...
Andrea Swei, Brandy J Russell, Samia N Naccache, Beniwende Kabre, Narayanan Veeraraghavan, Mark A Pilgard, Barbara J B Johnson, Charles Y Chiu   +7 more
doaj   +1 more source

Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins

mSphere, 2017
In recent years, several newly discovered tick-borne viruses causing a wide spectrum of diseases in humans have been ascribed to the Phlebovirus genus of the Bunyaviridae family.
Veronica V. Rezelj, Ping Li, Vidyanath Chaudhary, Richard M. Elliott, Dong-Yan Jin, Benjamin Brennan   +5 more
doaj   +1 more source

Novel Phlebovirus with Zoonotic Potential Isolated from Ticks, Australia

Emerging Infectious Diseases, 2014
Recently discovered tick-borne phleboviruses have been associated with severe disease and death among persons in Asia and the United States. We report the discovery of a novel tick phlebovirus in Tasmania State, Australia, that is closely related to ...
Jianning Wang, Paul Selleck, Meng Yu, Wendy Ha, Chrissy Rootes, Rosemary Gales, Terry Wise, Sandra Crameri, Honglei Chen, Ivano Broz, Alex Hyatt, Rupert Woods, Brian Meehan, Sam McCullough, Lin-Fa Wang   +14 more
doaj   +1 more source

First report of Lihan Tick virus (Phlebovirus, Phenuiviridae) in ticks, Colombia

Virology Journal, 2020
Background Tick-borne phenuivirus (TBPVs) comprise human and animal viruses that can cause a variety of clinical syndromes ranging from self-limiting febrile illness to fatal haemorrhagic fevers.
Yesica López, Jorge Miranda, Salim Mattar, Marco Gonzalez, Joel Rovnak   +4 more
doaj   +1 more source