Results 101 to 110 of about 11,230,134 (287)

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Neighborhood-Level Green Infrastructure and Heat-Related Health Risks in Tabriz, Iran: A Spatial Epidemiological Analysis

Atmosphere
Urban heat waves are intensifying under climate change, posing growing public health risks, particularly in rapidly urbanizing cities. Green infrastructure is widely promoted as a nature-based solution for heat mitigation, yet its health benefits may ...
Maryam Rezaei Ghaleh, Robert Balling
doaj   +1 more source

Thermal Exposure and Heat Illness Symptoms among Workers in Mara Gold Mine, Tanzania

Annals of Global Health, 2018
Background: Working in a humid and hot environment creates challenges to occupational health and safety in tropical countries. Being in the region, Tanzania can experiences more than 30°C ambient temperature, which exposes miners to heat-related injury ...
E. B. Meshi, S. S. Kishinhi, S. H. Mamuya, M. G. Rusibamayila   +3 more
doaj   +1 more source

Heat-related illness in individuals using psychiatric medication : 2016.

, 2016
Brochure; intended to be printed off on one sheet, front and back, and folded in thirds.; Harvested from the web on 6/2/16Common psychotropic medications that can impair the heat response -- Medical conditions and medications affect body temperature ...

core  

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Warning signs and symptoms of heat-related illness [Spanish]

Warning signs and symptoms of heat-related illness [Spanish]Las enfermedades relacionadas con el calor se pueden prevenir. Aprenda los s\uedntomas y lo que tiene que hacer si usted o un ser querido muestran signos de una enfermedad relacionada con el ...

core  

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Dog owners’ perceptions and behaviors regarding extreme heat and weather events

Human-Animal Interactions
Extreme heat and environmental disasters pose significant threats to canine health and welfare. With climate change intensifying these hazards and approximately 59.9 million U.S.
Ashley Etue, Lori R. Kogan, Emma Brown
doaj   +1 more source

Medicines can affect thermoregulation and accentuate the risk of dehydration and heat-related illness during hot weather

, 2015
What is Known and objectiveHot days are increasingly common and are often associated with increased morbidity and mortality, especially in the elderly.
Westaway, K., Frank, O., Rowett, D., Husband, A., McClure, A., Shute, R., Curtis, J., Edwards, S.   +7 more
core   +1 more source