Results 181 to 190 of about 257,240 (309)

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Heat Shock Proteins 60 and 70, Ki67 and Caspase 3 Are Differentially Expressed in the Canine Pregnant and Non-Pregnant Uterus and Ovaries. [PDF]

Vet Sci
Sabine SS, Firdevs B, Duygu K, Muhammed Ali K, Serhan A, Murat F, Selim A.   +6 more
europepmc   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Targeting histone deacetylation, cell cycle regulators and heat shock proteins as novel therapeutic strategies for penile cancers. [PDF]

NPJ Precis Oncol
Marson L, Skowron MA, Pongratanakul P, Kotthoff M, Poschmann G, Bohnenberger H, Stephan A, Watolla MM, Mukinovic E, Stühler K, Kurz T, Ayoubian H, Linxweiler J, Junker K, Nettersheim D.   +14 more
europepmc   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Heat shock proteins in osteoarthritis: molecular mechanisms, pathogenic roles, and therapeutic opportunities. [PDF]

Front Immunol
Zhao B, Deng Z, Yang Z, Yang F, Yang W.
europepmc   +1 more source

The heat shock response of Mycobacterium tuberculosis: linking gene expression, immunology and pathogenesis [PDF]

, 2002
Joseph A. Mangan, Richard Stabler, Philip D. Butcher, Butcher, PD, Wernisch, L, Lorenz Wernisch, Ken G. Laing, Graham R. Stewart, Young, DB, Stabler, R, Hinds, J, Mangan, JA, Jason Hinds, Wermisch, L, Stewart, GR, Laing, KG, Douglas B. Young   +16 more
core   +1 more source

Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs

Advanced Science, EarlyView.
Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan, Haofeng Chen, Yan Wang, Junyi Wang, Yueyang Chen, Yang Zhang, Jinting Guan, Jifeng Yuan   +7 more
wiley   +1 more source

Heat Shock Proteins in Pancreatic Cancer: Pathogenic Mechanisms and Clinical Implications. [PDF]

Cells
Kabut J, Sokołowski J, Żelazna W, Stępień M, Strauchman M, Jaworska N, Wnuk J, Gorzelak-Magiera A, Michalecki Ł, Gisterek-Grocholska I.   +9 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source