The Emerging Role of Heat Shock Factor 1 (HSF1) and Heat Shock Proteins (HSPs) in Ferroptosis [PDF]
Pathophysiology, 2023 Cells employ a well-preserved physiological stress response mechanism, termed the heat shock response, to activate a certain type of molecular chaperone called heat shock proteins (HSPs).
Iman Aolymat +2 more
doaj +2 more sources
Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response [PDF]
Cell Reports, 2023 Summary: Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts ...
Meng Xu +8 more
doaj +2 more sources
Robust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor
Frontiers in Microbiology, 2022 Cells reprogram their transcriptome in response to stress, such as heat shock. In free-living bacteria, the transcriptomic reprogramming is mediated by increased DNA-binding activity of heat shock sigma factors and activation of genes normally repressed ...
Yehong Huang +12 more
doaj +1 more source
Heat shock transcription factor HSFB2b negatively regulates plant thermomorphogenesis in Arabidopsis
浙江大学学报. 农业与生命科学版, 2023 In order to explore whether heat shock transcription factor (HSF) known to be involved in plant adaptation to extreme heat stress is also involved in plant thermomorphogenesis at warm temperatures, the result of CRISPR/Cas9 gene editing, physiological ...
YAO Ziwei +3 more
doaj +1 more source
Effect of heat shock transcription factor 5(Hsf5) knockdown on heat shock family in mouse Leydig cells and Sertoli cells [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the effect of knockdown heat shock transcription factor 5(Hsf5) on the expression of heat shock family in mouse Leydig cells (TM3) and Sertoli cells(TM4).
ZHONG Lin, ZHONG Hongli, DAI Yujie, ZHANG Qinghua
doaj +1 more source
Experimental Study on the Evolution of Granite Permeability Under Thermal Shock
Taiyuan Ligong Daxue xuebao, 2021 In order to reveal the change law of permeability of high-temperature granite under thermal shock, the permeability of granite specimens at different temperatures was investigated under four cooling conditions: natural cooling in air and thermal shock ...
Zepeng CHENG +4 more
doaj +1 more source
Is there a role for HSF1 in viral infections?
FEBS Open Bio, 2022 Cells undergo numerous processes to adapt to new challenging conditions and stressors. Heat stress is regulated by a family of heat shock factors (HSFs) that initiate a heat shock response by upregulating the expression of heat shock proteins (HSPs ...
Antonia Reyes +4 more
doaj +1 more source
Transient intracellular acidification regulates the core transcriptional heat shock response
eLife, 2020 Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought ...
Catherine G Triandafillou +3 more
doaj +1 more source
Immunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activator. [PDF]
PLoS Neglected Tropical Diseases, 2014 Schistosomiasis is a chronically debilitating disease caused by parasitic worms of the genus Schistosoma, and it is a global problem affecting over 240 million people.
Kenji Ishida +3 more
doaj +1 more source
The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. [PDF]
PLoS ONE, 2013 The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce the
Rachel Raynes +5 more
doaj +1 more source