Results 1 to 10 of about 13,686 (217)

HSF1 protects cells from cadmium toxicity by governing proteome integrity

Ecotoxicology and Environmental Safety, 2023
Background: Cadmium toxicity has been associated with disruption of protein homeostasis by interfering with protein folding processes. Heat shock factor 1 (HSF1) coordinates the rapid and extensive cellular response to maintain proteomic balance facing ...
Lusha Liu
exaly   +3 more sources

HSF1–DBC1 axis drives prostate cancer progression by activating a metastatic transcriptional program [PDF]

Experimental and Molecular Medicine
Heat shock factor 1 (HSF1) is a key stress-protective transcription factor that acts as a guardian of proteostasis. HSF1 also plays multifaceted roles in tumor-associated processes including proliferation and metastasis.
Sue Jin Moon, Hwa Jin Kim, Joung Eun Lim, Sanghoon Hong, Hong-Hee Won, Byong Chang Jeong, Jeong Hoon Kim   +6 more
doaj   +2 more sources

HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity

Cells, 2020
Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for responding to proteotoxic stress and involves the rapid expression of heat ...
Stuart Calderwood, Benjamin Lang, Martin Eduardo Guerrero-Gimenez   +2 more
exaly   +3 more sources

HSF1 Attenuates the Release of Inflammatory Cytokines Induced by Lipopolysaccharide through Transcriptional Regulation of Atg10

Microbiology Spectrum, 2023
Autophagy plays an important role in endotoxemic mice, and heat shock factor 1 (HSF1) plays a crucial protective role in endotoxemic mice. However, the protective mechanisms of HSF1 are poorly understood.
Hong Tan, Feifei Huang, Meiyuan Huang, Xia Wu, Zhongyi Tong   +4 more
doaj   +1 more source

Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis

Hepatology Communications, 2022
Liver fibrosis is an aberrant wound healing response that results from chronic injury and is mediated by hepatocellular death and activation of hepatic stellate cells (HSCs).
Asmita Choudhury, Anuradha Ratna, Arlene Lim, Rebecca M. Sebastian, Christopher L. Moore, Aveline A. Filliol, Jacob Bledsoe, Chengkai Dai, Robert F. Schwabe, Matthew D. Shoulders, Pranoti Mandrekar   +10 more
doaj   +1 more source

In silico analysis of the structural and functional consequences of polymorphic amino acid substitutions in the cattle hsf1 protein [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
Heat stress causes a decrease in the productivity of livestock by negatively aff ecting some important economic features such as fertility, growth and milk production.
Sertaç ATALAY
doaj   +1 more source

A simplified and sensitive immunoprecipitation approach for the analysis of HSF1 in murine liver tissue

MethodsX, 2021
Heat shock factor 1, HSF1, is one of several family members that recognize repeated nGAAn sequences associated with the heat shock element of heat shock and other genes.
Rachana Trivedi, Jitendra Kumar Tripathi, Bailey Knopf, Gunjan Dhawan Manocha, Donald A. Jurivich   +4 more
doaj   +1 more source

HSF1 Can Prevent Inflammation following Heat Shock by Inhibiting the Excessive Activation of the ATF3 and JUN&FOS Genes

Cells, 2022
Heat Shock Factor 1 (HSF1), a transcription factor frequently overexpressed in cancer, is activated by proteotoxic agents and participates in the regulation of cellular stress response.
Patryk Janus, Paweł Kuś, Natalia Vydra, Agnieszka Toma-Jonik, Tomasz Stokowy, Katarzyna Mrowiec, Bartosz Wojtaś, Bartłomiej Gielniewski, Wiesława Widłak   +8 more
doaj   +1 more source

β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer

Molecular Cancer, 2020
Background Heat shock transcription factor1 (HSF1) was overexpressed to promote glutaminolysis and activate mTOR in colorectal cancer (CRC). Here, we investigated the mechanism for cancer-specific overexpression of HSF1.
Ping Song, Lifeng Feng, Jiaqiu Li, Dongjun Dai, Liyuan Zhu, Chaoqun Wang, Jingyi Li, Ling Li, Qiyin Zhou, Rongkai Shi, Xian Wang, Hongchuan Jin   +11 more
doaj   +1 more source

Manipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression. [PDF]

PLoS ONE, 2010
BACKGROUND: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in the Xenopus tadpole.
Ron P Dirks, Remon van Geel, Sanne M M Hensen, Siebe T van Genesen, Nicolette H Lubsen   +4 more
doaj   +1 more source