The role of the nucleus in the control of mitochondrial precursor proteins in yeast. [PDF]
Protein SciAbstract Mitochondria are essential organelles of eukaryotic cells, with vital roles in energy production, biosynthesis of macromolecules, and intracellular signaling. Their function depends on a complex proteome with proteins targeted to different mitochondrial sub‐compartments.
Ritzenhofen K +3 more
europepmc +2 more sources
HSF1–DBC1 axis drives prostate cancer progression by activating a metastatic transcriptional program [PDF]
Experimental and Molecular MedicineHeat shock factor 1 (HSF1) is a key stress-protective transcription factor that acts as a guardian of proteostasis. HSF1 also plays multifaceted roles in tumor-associated processes including proliferation and metastasis.
Sue Jin Moon +6 more
doaj +2 more sources
Holding but not folding: How a single charge flip uncouples the DNAJC7-Hsp70 relay in amyotrophic lateral sclerosis. [PDF]
FEBS JIn this issue, Elmaleh et al. demonstrate that the E425K mutation in DNAJC7, associated with amyotrophic lateral sclerosis, selectively abolishes one of a co‐chaperone's dual functions. High‐resolution NMR confirmed that the mutation leaves the protein's structure intact while paralyzing its communication with the Hsp70 machinery.
Chiang TS, Boisbouvier J, Gandy LA.
europepmc +2 more sources
Lactobacillus paracasei L9 Ameliorates Pulmonary Fibrosis in Aged Mice via Gut-Lung Axis-Mediated Regulation of Immune Cell Migration. [PDF]
Aging CellOral administration of Lactobacillus paracasei L9 (L9) reshapes the gut microbiota, specifically increasing the abundance of short‐chain fatty acid (SCFA)‐producing bacteria (e.g., Blautia), thereby leading to a significant elevation of serum propionic acid (97% increase) and butyric acid (193% increase).
Bi R +10 more
europepmc +2 more sources
HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity
Cells, 2020 Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for responding to proteotoxic stress and involves the rapid expression of heat ...
Thomas L Prince +2 more
exaly +3 more sources
Microbiology Spectrum, 2023 Autophagy plays an important role in endotoxemic mice, and heat shock factor 1 (HSF1) plays a crucial protective role in endotoxemic mice. However, the protective mechanisms of HSF1 are poorly understood.
Hong Tan +4 more
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HSF1 protects cells from cadmium toxicity by governing proteome integrity
Ecotoxicology and Environmental Safety, 2023 Background: Cadmium toxicity has been associated with disruption of protein homeostasis by interfering with protein folding processes. Heat shock factor 1 (HSF1) coordinates the rapid and extensive cellular response to maintain proteomic balance facing ...
Yuchun Zhang +8 more
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Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis
Hepatology Communications, 2022 Liver fibrosis is an aberrant wound healing response that results from chronic injury and is mediated by hepatocellular death and activation of hepatic stellate cells (HSCs).
Asmita Choudhury +10 more
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In silico analysis of the structural and functional consequences of polymorphic amino acid substitutions in the cattle hsf1 protein [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Heat stress causes a decrease in the productivity of livestock by negatively aff ecting some important economic features such as fertility, growth and milk production.
Sertaç ATALAY
doaj +1 more source
MethodsX, 2021 Heat shock factor 1, HSF1, is one of several family members that recognize repeated nGAAn sequences associated with the heat shock element of heat shock and other genes.
Rachana Trivedi +4 more
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