Results 1 to 10 of about 20,857 (230)
Molecular Cancer, 2020 Background Heat shock transcription factor1 (HSF1) was overexpressed to promote glutaminolysis and activate mTOR in colorectal cancer (CRC). Here, we investigated the mechanism for cancer-specific overexpression of HSF1.
Ping Song, Lifeng Feng, Jiaqiu Li
exaly +3 more sources
HSF1–DBC1 axis drives prostate cancer progression by activating a metastatic transcriptional program [PDF]
Experimental and Molecular MedicineHeat shock factor 1 (HSF1) is a key stress-protective transcription factor that acts as a guardian of proteostasis. HSF1 also plays multifaceted roles in tumor-associated processes including proliferation and metastasis.
Sue Jin Moon +6 more
doaj +2 more sources
Peripheral lncRNA-IL1RAP Dysregulation in Schizophrenia: A Multi-Omics Bridge Between Immunity and Diagnosis. [PDF]
Brain BehavBulk RNA‐seq of PBL from first‐episode or unmedicated SCZ patients identifies an opposite‐direction two‐lncRNA signal at the CCR3 and IL1RAP loci, supported by qRT–PCR and yielding strong internal but uncertain external discrimination. Immune‐linked programs recurrently involve IL1RAP/IL‐1 branches and map, in a healthy‐donor PBMC single‐cell reference,
Wu J +7 more
europepmc +2 more sources
Logic-Gated HSV-TK/GCV Suicide Gene Circuit for Triple-Negative Breast Cancer. [PDF]
Adv Sci (Weinh)The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Tang S +10 more
europepmc +2 more sources
HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity
Cells, 2020 Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for responding to proteotoxic stress and involves the rapid expression of heat ...
Thomas L Prince +2 more
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Re-Evaluating Hot Mitochondria: Too Slow to Cool. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Mito Thermo Yellow (MTY) is a mitochondrially targeted fluorophore that shows marked fluorescence quenching with increasing temperature, allowing for interrogating temperature dynamics in the mitochondria of live cells. Here we re‐evaluate published MTY fluorescence responses used to argue in favor of the ‘hot mitochondria’ concept; the ...
Treberg JR, Mailloux RJ.
europepmc +2 more sources
Microbiology Spectrum, 2023 Autophagy plays an important role in endotoxemic mice, and heat shock factor 1 (HSF1) plays a crucial protective role in endotoxemic mice. However, the protective mechanisms of HSF1 are poorly understood.
Hong Tan +4 more
doaj +1 more source
HSF1 protects cells from cadmium toxicity by governing proteome integrity
Ecotoxicology and Environmental Safety, 2023 Background: Cadmium toxicity has been associated with disruption of protein homeostasis by interfering with protein folding processes. Heat shock factor 1 (HSF1) coordinates the rapid and extensive cellular response to maintain proteomic balance facing ...
Yuchun Zhang +8 more
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Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis
Hepatology Communications, 2022 Liver fibrosis is an aberrant wound healing response that results from chronic injury and is mediated by hepatocellular death and activation of hepatic stellate cells (HSCs).
Asmita Choudhury +10 more
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In silico analysis of the structural and functional consequences of polymorphic amino acid substitutions in the cattle hsf1 protein [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Heat stress causes a decrease in the productivity of livestock by negatively aff ecting some important economic features such as fertility, growth and milk production.
Sertaç ATALAY
doaj +1 more source