Lack of peroxisomal catalase affects heat shock response in Caenorhabditis elegans [PDF]
Life Science Alliance, 2023 The authors present a previously unknown crosstalk between peroxisomes and the heat shock response, whereby the peroxisomal catalase is vital for cellular capacity to survive heat stress and undergo heat-induced lifespan extension.
Marina Musa +5 more
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The Pathophysiological Role of Heat Shock Response in Autoimmunity: A Literature Review
Cells, 2021 Within the last two decades, there has been increasing evidence that heat-shock proteins can have a differential influence on the immune system. They can either provoke or ameliorate immune responses.
Ariadni Androvitsanea +3 more
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The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. [PDF]
PLoS ONE, 2013 The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce the
Rachel Raynes +5 more
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Virulence and the heat shock response
International Journal of Medical Microbiology, 2003 The major adaptive response to elevation in temperature is the heat shock response that involves the induction of many proteins--called heat shock proteins. These include chaperones, proteases, alternative sigma factors and other regulatory and structural proteins.
Uri Gophna, Eliora Z Ron
exaly +3 more sources
Transcriptional and translational dynamics underlying heat shock response in the thermophilic crenarchaeon Sulfolobus acidocaldarius [PDF]
mBio, 2023 High-temperature stress is critical for all organisms and induces a profound cellular response. For Crenarchaeota, little information is available on how heat shock affects cellular processes and on how this response is regulated.
Rani Baes +10 more
doaj +2 more sources
Unveiling the novel regulatory roles of RpoD-family sigma factors in Salmonella Typhimurium heat shock response through systems biology approaches. [PDF]
PLoS GeneticsThree RpoD-family sigma factors, RpoD, RpoS, and RpoH, play critical roles in transcriptional regulation in Salmonella enterica serovar Typhimurium under heat shock conditions.
Joon Young Park +5 more
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The Heat Shock Response as a Condensate Cascade. [PDF]
J Mol BiolThe heat shock response (HSR) is a gene regulatory program controlling expression of molecular chaperones implicated in aging, cancer, and neurodegenerative disease. Long presumed to be activated by toxic protein aggregates, recent work suggests a new functional paradigm for the HSR in yeast.
Dea A, Pincus D.
europepmc +3 more sources
Heat Shock Response - Pathophysiological Implications
Annals of Medicine, 1997 All organisms exposed to environmental stress conditions share a common molecular response characterized by a dramatic change in the pattern of gene expression followed by an elevated synthesis of heat shock or stress proteins. These proteins function as molecular chaperones to protect cells from environmental stress damage by binding to partially ...
Lea Sistonen
exaly +3 more sources
The heat shock response and small molecule regulators [PDF]
European Journal of Medicinal Chemistry, 2021 Margaret K Kurop +2 more
exaly +2 more sources
Thermodynamics of Heat-Shock Response [PDF]
Physical Review Letters, 2000 Production of heat shock proteins are induced when a living cell is exposed to a rise in temperature. The heat shock response of protein DnaK synthesis in E.coli for temperature shifts from temperature T to T plus 7 degrees, respectively to T minus 7 degrees is measured as function of the initial temperature T. We observe a reversed heat shock at low T.
Arnvig, KB, Pedersen, S, Sneppen, K
openaire +4 more sources