Results 41 to 50 of about 6,994,266 (255)
G3: Genes, Genomes, Genetics, 2023 Heat-shock-inducible expression of genes through the use of heat-inducible promoters is commonly used in research despite leaky expression of downstream genes of interest without targeted induction (i.e. heat shock).
Natalie Warsinger-Pepe +3 more
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Heat shock response and homeostatic plasticity
Frontiers in Cellular Neuroscience, 2015 Heat shock response and homeostatic plasticity are mechanisms that afford functional stability to cells in the face of stress. Each mechanism has been investigated independently, but the link between the two has not been extensively explored.
SHANKER eKARUNANITHI, Ian Ross Brown
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Menin links the stress response to genome stability in Drosophila melanogaster. [PDF]
PLoS ONE, 2010 The multiple endocrine neoplasia type I gene functions as a tumor suppressor gene in humans and mouse models. In Drosophila melanogaster, mutants of the menin gene (Mnn1) are hypersensitive to mutagens or gamma irradiation and have profound defects in ...
Maria Papaconstantinou +6 more
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I. The Use of a Large Conventional Shock Tube as a Pre-Ionizer for an Inverse Pinch Shock Tube. II. The Application of Thin-Film Heat Transfer Gauges and Flush Electrostatic Probes to Partially Ionized Flows in Shock Tubes [PDF]
, 1967 Part 1. A large diameter (17"), conventional shock tube has been used as the pre-ionizer for an inverse pinch shock tube in an attempt to achieve separation of the shock front and the current sheath in the inverse pinch.
Klein, Alan Frank
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Characterizing primary transcriptional responses to short term heat shock in Down syndrome.
PLoS ONEHeat shock stress induces genome-wide changes in transcription regulation, activating a coordinated cellular response to enable survival. We noticed many heat shock genes are up-regulated in blood samples from individuals with trisomy 21.
Joseph F Cardiello +3 more
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Frontiers in MicrobiologyThe heat shock response of Escherichia coli represents a canonical example of how bacteria can recognize a stress and invoke a protective response by altering specific gene regulation.
Muhammad Yasir +20 more
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Barcoding heat shock proteins to human diseases: looking beyond the heat shock response
Disease Models & Mechanisms, 2014 There are numerous human diseases that are associated with protein misfolding and the formation of toxic protein aggregates. Activating the heat shock response (HSR) – and thus generally restoring the disturbed protein homeostasis associated with such ...
Vaishali Kakkar +4 more
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