Results 41 to 50 of about 211,923 (255)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Menin links the stress response to genome stability in Drosophila melanogaster. [PDF]

PLoS ONE, 2010
The multiple endocrine neoplasia type I gene functions as a tumor suppressor gene in humans and mouse models. In Drosophila melanogaster, mutants of the menin gene (Mnn1) are hypersensitive to mutagens or gamma irradiation and have profound defects in ...
Maria Papaconstantinou, Alicia N Pepper, Ying Wu, Dahlia Kasimer, Tim Westwood, Ana Regina Campos, Pierre-André Bédard   +6 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Characterizing primary transcriptional responses to short term heat shock in Down syndrome.

PLoS ONE
Heat shock stress induces genome-wide changes in transcription regulation, activating a coordinated cellular response to enable survival. We noticed many heat shock genes are up-regulated in blood samples from individuals with trisomy 21.
Joseph F Cardiello, Jessica Westfall, Robin Dowell, Mary Ann Allen   +3 more
doaj   +1 more source

Prior exposure strongly influences mechanisms underpinning survival of heat shock in Escherichia coli

Frontiers in Microbiology
The heat shock response of Escherichia coli represents a canonical example of how bacteria can recognize a stress and invoke a protective response by altering specific gene regulation.
Muhammad Yasir, Muhammad Yasir, A. Keith Turner, A. Keith Turner, Sarah Bastkowski, Sarah Bastkowski, Caroline S. Jarvis, Caroline S. Jarvis, Caroline S. Jarvis, Ryan Sweet, Ryan Sweet, Megan Truong, Megan Truong, Megan Truong, Megan Truong, Ian G. Charles, Ian G. Charles, Ian G. Charles, Mark A. Webber, Mark A. Webber, Mark A. Webber   +20 more
doaj   +1 more source

Barcoding heat shock proteins to human diseases: looking beyond the heat shock response

Disease Models & Mechanisms, 2014
There are numerous human diseases that are associated with protein misfolding and the formation of toxic protein aggregates. Activating the heat shock response (HSR) – and thus generally restoring the disturbed protein homeostasis associated with such ...
Vaishali Kakkar, Melanie Meister-Broekema, Melania Minoia, Serena Carra, Harm H. Kampinga   +4 more
doaj   +1 more source

Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes. [PDF]

PLoS ONE, 2010
Metallothioneins (MTs) are small, cysteine-rich polypeptides, but the role of MTs in inducing the formation of adaptive response is still largely unknown.
Boping Ye, Qi Rui, Qiuli Wu, Dayong Wang
doaj   +1 more source

Correction: Heat shock response in archaea [PDF]

Emerging Topics in Life Sciences, 2018
Emerging Topics in Life Sciences (2018) https://doi.org/10.1042/ETLS20180024 In the Ahead-of-Print version published on 22 November 2018, the titles/captions for [Figures 1][1] and [3][2] were accompanied by the wrong artwork.
Liesbeth, Lemmens, Rani, Baes, Eveline, Peeters   +2 more
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source