Results 11 to 20 of about 13,686 (217)

HSF1 in Translation [PDF]

Cancer Cell, 2013
The master regulator of the classical cytoprotective "heat shock" response, heat shock factor 1 (HSF1), is increasingly implicated in cancer pathogenesis, but the mechanisms remain poorly understood. A recent study connects increased protein translation to activation of HSF1 in malignant cells and demonstrates the therapeutic benefit of targeting this ...
de Billy, Emmanuel, Clarke, Paul A., Workman, Paul   +2 more
openaire   +4 more sources

Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation [PDF]

Journal of Biological Chemistry, 2021
Heat shock transcription factor 1 (HSF1) orchestrates cellular stress protection by activating or repressing gene transcription in response to protein misfolding, oncogenic cell proliferation, and other environmental stresses. HSF1 is tightly regulated via intramolecular repressive interactions, post-translational modifications, and protein-protein ...
Eileen T. Burchfiel, Anniina Vihervaara, Michael J. Guertin, Rocio Gomez-Pastor, Dennis J. Thiele   +4 more
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Repression motif in HSF1 regulated by phosphorylation [PDF]

Cellular Signalling, 2023
The heat shock factor 1 (HSF1) is a transcription factor that itself is a sensor for stress and integrates various intrinsic or environmental stress sensing pathways. Thus HSF1 orchestrates the heat shock response (HSR) by translating these pathways into a distinct transcriptional program that aids the cells to cope with and adapt to proteotoxic stress.
Stefan, Gabriel, Thomas, Czerny, Elisabeth, Riegel   +2 more
openaire   +3 more sources

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation [PDF]

Scientific Reports, 2018
Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program.
Toshiki Kijima, Thomas L. Prince, Megan L. Tigue, Kendrick H. Yim, Harvey Schwartz, Kristin Beebe, Sunmin Lee, Marek A. Budzynski, Heinric Williams, Jane B. Trepel, Lea Sistonen, Stuart Calderwood, Len Neckers   +12 more
doaj   +4 more sources

HSF1 Activation Can Restrict HIV Replication [PDF]

ACS Infectious Diseases, 2020
Host protein folding stress responses can play important roles in RNA virus replication and evolution. Prior work suggested a complicated interplay between the cytosolic proteostasis stress response, controlled by the transcriptional master regulator heat shock factor 1 (HSF1), and human immunodeficiency virus-1 (HIV-1).
Emmanuel E. Nekongo, Anna I. Ponomarenko, Mahender B. Dewal, Vincent L. Butty, Edward P. Browne, Matthew D. Shoulders   +5 more
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HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways [PDF]

Cancers, 2019
Heat shock factor 1 (HSF1) is an essential transcription factor in cellular adaptation to various stresses such as heat, proteotoxic stress, metabolic stress, reactive oxygen species, and heavy metals. HSF1 promotes cancer development and progression, and increased HSF1 levels are frequently observed in multiple types of cancers.
Kang, Hyeji, Oh, Taerim, Bahk, Young Yil, Kim, Geon-Hee, Kan, Sang-Yeon, Shin, Dong Hoon, Kim, Ji Hyung, Lim, Ji-Hong   +7 more
openaire   +4 more sources

Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q [PDF]

Human Genomics, 2017
Background HSF1 (heat shock factor 1) is a transcription factor that is found to facilitate malignant cancer development and proliferation. In cancer cells, HSF1 mediates a set of genes distinct from heat shock that contributes to malignancy. This set of
Christopher Q. Zhang, Heinric Williams, Thomas L. Prince, Eric S. Ho   +3 more
doaj   +2 more sources

Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1 [PDF]

eLife, 2019
Hsf1 is an ancient transcription factor that responds to protein folding stress by inducing the heat-shock response (HSR) that restore perturbed proteostasis. Hsp70 chaperones negatively regulate the activity of Hsf1 via stress-responsive mechanisms that
Anna E Masser, Wenjing Kang, Joydeep Roy, Jayasankar Mohanakrishnan Kaimal, Jany Quintana-Cordero, Marc R Friedländer, Claes Andréasson   +6 more
doaj   +2 more sources

Quantitative Comparison of HSF1 Activators [PDF]

Molecular Biotechnology, 2022
AbstractThe heat shock response (HSR) pathway is a highly conserved rescue mechanism, which protects the cells from harmful insults disturbing the cellular protein homeostasis via expression of chaperones. Furthermore, it was demonstrated to play crucial roles in various diseases like neurodegeneration and cancer.
Christoph Steurer, Sarah Kerschbaum, Christina Wegrostek, Stefan Gabriel, Ali Hallaj, Viktoria Ortner, Thomas Czerny, Elisabeth Riegel   +7 more
openaire   +2 more sources

Interaction between Maslinic acid and HSF1 enhances the ubiquitin degradation of HSF1, resulting in the inhibitory effect of pancreatic cancer [PDF]

Discover Oncology
Maslinic acid (MA), a pentacyclic triterpenoid, displays broad biological activity including anti-inflammatory, antihyperlipidemic, anti-tumor, cardiovascular protection etc. Our previous study has shown that MA inhibits the proliferation of pancreatic cancer cells via heat shock protein HSPA8-mediated autophagy pathway, but the detailed mechanism is ...
Li Cheng, Mingyue Guo, Ammad Ahmad Farooqi, Linlin Wang, Yuxi Zhang, Hanlin Ye, Gan Qiao, Xiukun Lin   +7 more
openaire   +4 more sources