Results 11 to 20 of about 20,857 (230)

Quantitative Comparison of HSF1 Activators [PDF]

Molecular Biotechnology, 2022
AbstractThe heat shock response (HSR) pathway is a highly conserved rescue mechanism, which protects the cells from harmful insults disturbing the cellular protein homeostasis via expression of chaperones. Furthermore, it was demonstrated to play crucial roles in various diseases like neurodegeneration and cancer.
Christoph Steurer, Sarah Kerschbaum, Christina Wegrostek, Stefan Gabriel, Ali Hallaj, Viktoria Ortner, Thomas Czerny, Elisabeth Riegel   +7 more
openaire   +2 more sources

HSF1 in Translation [PDF]

Cancer Cell, 2013
The master regulator of the classical cytoprotective "heat shock" response, heat shock factor 1 (HSF1), is increasingly implicated in cancer pathogenesis, but the mechanisms remain poorly understood. A recent study connects increased protein translation to activation of HSF1 in malignant cells and demonstrates the therapeutic benefit of targeting this ...
de Billy, Emmanuel, Clarke, Paul A., Workman, Paul   +2 more
openaire   +2 more sources

HSF1 at a glance [PDF]

Journal of Cell Science, 2014
ABSTRACTHeat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription factor that coordinates stress-induced transcription and directs versatile physiological processes in eukaryotes. The central position of HSF1 in cellular homeostasis has been well demonstrated, mainly through its strong effect in transactivating genes that encode ...
Vihervaara A, Sistonen L
openaire   +3 more sources

A simplified and sensitive immunoprecipitation approach for the analysis of HSF1 in murine liver tissue

MethodsX, 2021
Heat shock factor 1, HSF1, is one of several family members that recognize repeated nGAAn sequences associated with the heat shock element of heat shock and other genes.
Rachana Trivedi, Jitendra Kumar Tripathi, Bailey Knopf, Gunjan Dhawan Manocha, Donald A. Jurivich   +4 more
doaj   +1 more source

Heat Shock Proteins and HSF1 in Cancer [PDF]

Frontiers in Oncology, 2022
Fitness of cells is dependent on protein homeostasis which is maintained by cooperative activities of protein chaperones and proteolytic machinery. Upon encountering protein-damaging conditions, cells activate the heat-shock response (HSR) which involves HSF1-mediated transcriptional upregulation of a group of chaperones – the heat shock proteins (HSPs)
Anna M. Cyran, Anatoly Zhitkovich
openaire   +3 more sources

HSF1 Can Prevent Inflammation following Heat Shock by Inhibiting the Excessive Activation of the ATF3 and JUN&FOS Genes

Cells, 2022
Heat Shock Factor 1 (HSF1), a transcription factor frequently overexpressed in cancer, is activated by proteotoxic agents and participates in the regulation of cellular stress response.
Patryk Janus, Paweł Kuś, Natalia Vydra, Agnieszka Toma-Jonik, Tomasz Stokowy, Katarzyna Mrowiec, Bartosz Wojtaś, Bartłomiej Gielniewski, Wiesława Widłak   +8 more
doaj   +1 more source

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast [PDF]

, 2012
Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 ...
A Ali, A Mitchell, A Plaine, A Roetzer, A Roetzer, A Walther, A Winkler, AA Duina, AE Piispanen, Alex Andrianopoulos, Alistair J. P. Brown, AP Gasch, B Eisman, B Enjalbert, B Enjalbert, B Enjalbert, BK Jakobsen, C Csank, C Giardina, C Queitsch, C San Jose, CA Munro, Carol Munro, CH de Dios, CJ Nobile, D Chen, DA Davis, DA Smith, DF Jarosz, DF Jarosz, DF Smith, DM Arana, DR Wysong, E Kussell, E Leberer, E Nikolaou, E Roman, EA Craig, EA Elion, ET Burt, F Estruch, F Lamoth, F Navarro-Garcia, F Navarro-Garcia, F Navarro-García, F Sherman, FA Guhad, G Degols, G Wiederrecht, G Wiederrecht, GJ Gallo, H Garreau, H Lavoie, HC Causton, I Tirosh, IV Ene, J Chen, J Zou, JL Brewster, JR Blankenship, K-H Chen, LA Walker, LA Walker, LE Cowen, Leah E. Cowen, Louise Walker, M Ramsdale, M Taipale, MD Leach, MD Leach, MD Leach, MD Leach, ME Feder, Michelle D. Leach, MM Bradford, N Shulga, P Gónzalez-Párraga, P Hawle, PD Cantero, PK Sorger, PK Sorger, R Alonso-Monge, R Alonso-Monge, R Diez-Orejas, RA Monge, RB Wilson, RS Hegde, RS Shapiro, S Bates, S Diezmann, S Kuge, S Nicholls, S Nicholls, S Nicholls, SD Singh, SH Millson, SK Prill, SL LaFayette, SL Rutherford, SM Noble, SM O'Rourke, SM Roe, Susan Budge, TT Wimalasena, VM Bruno, VM Bruno, WA Fonzi, WM Toone, X Zhang, Y Guo, Y Kamada   +110 more
core   +6 more sources

Manipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression. [PDF]

PLoS ONE, 2010
BACKGROUND: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in the Xenopus tadpole.
Ron P Dirks, Remon van Geel, Sanne M M Hensen, Siebe T van Genesen, Nicolette H Lubsen   +4 more
doaj   +1 more source

Effects of FBXW7α on Expression and Localization of Heat Shock Transcription Factor 1 in Colorectal Cancer Cells

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the effect of FBXW7 on the expression and localization of HSF1 in colorectal cancer cells. Methods The expression levels of HSF1 and pHSF1Ser326 protein in FBXW7 deletion (KO) and wild-type (WT) FBXW7-expressing counterpart ...
SUN Ao, JIAO Han, FU Jiejun
doaj   +1 more source

Heat shock factor 1 suppression induces spindle abnormalities and sensitizes cells to antimitotic drugs

Cell Division, 2021
Background Heat shock factor 1 (HSF1) is the master regulator of the heat shock response and supports malignant cell transformation. Recent work has shown that HSF1 can access the promoters of heat shock proteins (HSPs) and allow HSP expression during ...
Hsiao-Hui Kuo, Zhi-Rou Su, Jing-Yuan Chuang, Ling-Huei Yih   +3 more
doaj   +1 more source