Results 11 to 20 of about 13,678 (223)
Cancer Cell, 2013 The master regulator of the classical cytoprotective “heat shock” response, heat shock factor 1 (HSF1), is increasingly implicated in cancer pathogenesis, but the mechanisms remain poorly understood.
de Billy, Emmanuel +2 more
core +3 more sources
Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation [PDF]
Journal of Biological Chemistry, 2021 Heat shock transcription factor 1 (HSF1) orchestrates cellular stress protection by activating or repressing gene transcription in response to protein misfolding, oncogenic cell proliferation, and other environmental stresses.
Thiele, Dennis J. +4 more
core +6 more sources
Repression motif in HSF1 regulated by phosphorylation
Cellular Signalling, 2023 The heat shock factor 1 (HSF1) is a transcription factor that itself is a sensor for stress and integrates various intrinsic or environmental stress sensing pathways. Thus HSF1 orchestrates the heat shock response (HSR) by translating these pathways into
Gabriel, Stefan +5 more
core +3 more sources
HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation [PDF]
Scientific Reports, 2018 Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program.
Toshiki Kijima +12 more
doaj +3 more sources
HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways [PDF]
Cancers, 2019 Heat shock factor 1 (HSF1) is an essential transcription factor in cellular adaptation to various stresses such as heat, proteotoxic stress, metabolic stress, reactive oxygen species, and heavy metals.
Sang-Yeon Kan +7 more
core +3 more sources
HSF1 Activation Can Restrict HIV Replication
ACS Infectious Diseases, 2021 Copyright © 2020 American Chemical Society. Host protein folding stress responses can play important roles in RNA virus replication and evolution. Prior work suggested a complicated interplay between the cytosolic proteostasis stress response, controlled
Ponomarenko, Anna I +5 more
core +5 more sources
Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q
Human Genomics, 2017 Background HSF1 (heat shock factor 1) is a transcription factor that is found to facilitate malignant cancer development and proliferation. In cancer cells, HSF1 mediates a set of genes distinct from heat shock that contributes to malignancy. This set of
Christopher Q. Zhang +3 more
doaj +2 more sources
Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1
eLife, 2019 Hsf1 is an ancient transcription factor that responds to protein folding stress by inducing the heat-shock response (HSR) that restore perturbed proteostasis. Hsp70 chaperones negatively regulate the activity of Hsf1 via stress-responsive mechanisms that
Anna E Masser +6 more
doaj +2 more sources
Quantitative Comparison of HSF1 Activators [PDF]
Molecular Biotechnology, 2022 AbstractThe heat shock response (HSR) pathway is a highly conserved rescue mechanism, which protects the cells from harmful insults disturbing the cellular protein homeostasis via expression of chaperones. Furthermore, it was demonstrated to play crucial roles in various diseases like neurodegeneration and cancer.
Christoph Steurer +7 more
openaire +2 more sources
Heat Shock Proteins and HSF1 in Cancer [PDF]
Frontiers in Oncology, 2022 Fitness of cells is dependent on protein homeostasis which is maintained by cooperative activities of protein chaperones and proteolytic machinery. Upon encountering protein-damaging conditions, cells activate the heat-shock response (HSR) which involves HSF1-mediated transcriptional upregulation of a group of chaperones – the heat shock proteins (HSPs)
Anna M. Cyran, Anatoly Zhitkovich
openaire +3 more sources