Results 31 to 40 of about 20,857 (230)
Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation
eLife, 2016 Heat shock factor (Hsf1) regulates the expression of molecular chaperones to maintain protein homeostasis. Despite its central role in stress resistance, disease and aging, the mechanisms that control Hsf1 activity remain unresolved. Here we show that in
Xu Zheng +6 more
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Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans [PDF]
, 2014 Peer reviewedPublisher ...
Cowen, Leah E., Leach, Michelle D.
core +1 more source
Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q
Human Genomics, 2017 Background HSF1 (heat shock factor 1) is a transcription factor that is found to facilitate malignant cancer development and proliferation. In cancer cells, HSF1 mediates a set of genes distinct from heat shock that contributes to malignancy. This set of
Christopher Q. Zhang +3 more
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HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways [PDF]
Cancers, 2019 Heat shock factor 1 (HSF1) is an essential transcription factor in cellular adaptation to various stresses such as heat, proteotoxic stress, metabolic stress, reactive oxygen species, and heavy metals. HSF1 promotes cancer development and progression, and increased HSF1 levels are frequently observed in multiple types of cancers.
Kang, Hyeji +7 more
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iScience, 2022 Summary: Endometriosis is a common chronic condition characterized by abnormal growth of the endometrium outside the uterus. Heat shock transcription factor 1 (HSF1) is a significant regulator of the proteotoxic stress response and plays an essential ...
Xi Ling +9 more
doaj +1 more source
Proteotoxic stress reprograms the chromatin landscape of SUMO modification [PDF]
, 2015 The small ubiquitin-like modifier 2 (SUMO-2) is required for survival when cells are exposed to treatments that induce proteotoxic stress by causing the accumulation of misfolded proteins.
Anne Seifert +4 more
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Scientific Reports, 2018 Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program.
Toshiki Kijima +12 more
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Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans [PDF]
, 2019 Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose
daeeun jeong +5 more
core +1 more source
NEDD4-mediated HSF1 degradation underlies α-synucleinopathy [PDF]
Human Molecular Genetics, 2015 Cellular protein homeostasis is achieved by a delicate network of molecular chaperones and various proteolytic processes such as ubiquitin-proteasome system (UPS) to avoid a build-up of misfolded protein aggregates. The latter is a common denominator of neurodegeneration.
Kim, Eunhee +6 more
openaire +2 more sources
Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast. [PDF]
PLoS ONE, 2011 Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that include protein
Liliana Batista-Nascimento +4 more
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