Results 31 to 40 of about 13,678 (223)
Protein kinase A binds and activates heat shock factor 1. [PDF]
PLoS ONE, 2010 Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli.
Ayesha Murshid +5 more
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Pleiotropic Role of HSF1 in Neoplastic Transformation [PDF]
Current Cancer Drug Targets, 2014 HSF1 (Heat Shock transcription Factor 1) is the main transcription factor activated in response to proteotoxic stress. Once activated, it induces an expression of heat shock proteins (HSPs) which enables cells to survive in suboptimal conditions. HSF1 could be also activated by altered kinase signaling characteristic for cancer cells, which is a ...
Vydra, Natalia +2 more
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Expression levels of HSF1 and HSF1-eGFP in stable HeLa cell lines.
, 2013 HSF1 western blotting of full protein extracts before (−) and after one hour heat shock (+), before (−) or after (+) HSF1-siRNA treatment, in control cells (Ctl), in cell lines expressing the full length HSF1-eGFP (wt), the HSF1-eGFP mutant deleted of ...
Antoine Delon (431449) +7 more
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Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation
eLife, 2016 Heat shock factor (Hsf1) regulates the expression of molecular chaperones to maintain protein homeostasis. Despite its central role in stress resistance, disease and aging, the mechanisms that control Hsf1 activity remain unresolved. Here we show that in
Xu Zheng +6 more
doaj +1 more source
The Multifaceted Role of HSF1 in Tumorigenesis
, 2020 Heat Shock Factor 1 (HSF1), the master transcriptional regulator of the heat shock response (HSR), was first cloned more than 30 years ago. Most early research interrogating the role that HSF1 plays in biology focused on its cytoprotective functions, as a factor that promotes the survival of organisms by protecting against the proteotoxicity associated
Milad J, Alasady, Marc L, Mendillo
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iScience, 2022 Summary: Endometriosis is a common chronic condition characterized by abnormal growth of the endometrium outside the uterus. Heat shock transcription factor 1 (HSF1) is a significant regulator of the proteotoxic stress response and plays an essential ...
Xi Ling +9 more
doaj +1 more source
HSF1, A Versatile Factor in Tumorogenesis [PDF]
Current Molecular Medicine, 2012 HSF1 is an essential factor in the acute response to proteotoxic stress, in which it causes rapid transcription of heat shock protein (HSP) genes in order to permit survival of cells and restoration of global protein quality. In addition to this property however, HSF1 is chronically activated or overexpressed in a wide range of cancers and is essential
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Molecularchaperones as HSF1-specific transcriptional repressors [PDF]
Genes & Development, 1998 The rapid yet transient transcriptional activation of heat shock genes is mediated by the reversible conversion of HSF1 from an inert negatively regulated monomer to a transcriptionally active DNA-binding trimer. During attenuation of the heat shock response, transcription of heat shock genes returns to basal levels and HSF1 reverts to an inert monomer.
Shi, Yanhong +2 more
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Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast. [PDF]
PLoS ONE, 2011 Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that include protein
Liliana Batista-Nascimento +4 more
doaj +1 more source
Is there a role for HSF1 in viral infections?
FEBS Open Bio, 2022 Cells undergo numerous processes to adapt to new challenging conditions and stressors. Heat stress is regulated by a family of heat shock factors (HSFs) that initiate a heat shock response by upregulating the expression of heat shock proteins (HSPs) intended to counteract cellular damage elicited by increased environmental temperature.
Antonia Reyes +4 more
openaire +3 more sources