Results 51 to 60 of about 13,678 (223)

HSF1 aptamer inhibits mitogenic signaling.

, 2014
(A) HSF1 inhibition attenuates EGF receptor activation following the addition of EGF to HeLa cells. (B) HSF1 inhibition by iaRNAHSF1 causes a depletion of the total levels and activated forms of Erk1/2.
Richard A. Cerione (464912), John T. Lis (7283), H. Hans Salamanca (560402), Marc A. Antonyak (560403), Hua Shi (7282)   +4 more
core   +1 more source

Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patients

Diagnostic Pathology, 2018
Background Heat shock factor 1 (HSF1) was initially identified as a transcription factor encoding heat shock proteins, which assist in refolding or degrading damaged proteins.
Weigang Dai, Jinning Ye, Zhimei Zhang, Liang Yang, Hui Ren, Hui Wu, Jianhui Chen, Jieyi Ma, Ertao Zhai, Shirong Cai, Yulong He   +10 more
doaj   +1 more source

HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression

Reproductive Biology and Endocrinology, 2021
Background Endometriosis is a chronic hormonal inflammatory disease characterized by the presence of endometrial tissue outside the uterus. Endometriosis often causes infertility, which brings physical and mental pain to patients and their families ...
Yixin Wang, Jing Xiu, Tingting Yang, Chune Ren, Zhenhai Yu   +4 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

FCS analysis of HSF1 -K80Q in immortalized MEFs form HSF1 null mice.

, 2013
Dynamics of HSF1- K80Q-eGFP and WT HSF1-eGFP before (NHS, blue) and after 30 minutes heat shock (HS, red) in immortalized MEFs from HSF1 null mice.
Antoine Delon (431449), Claire Vourc’h (431448), Gaëtan Herbomel (431444), Yves Usson (431447), Eric G. Folco (310374), Catherine Souchier (431450), Meike Kloster-Landsberg (431445), Edwige Col (431446)   +7 more
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

mFCS analysis of HSF1 -K80Q in cells knocked-down for endogenous HSF1.

, 2013
Dynamics of HSF1- K80Q-eGFP before (NHS, blue) and after a one hour heat shock (HS, red), in cells knocked-down for endogenous HSF1. mFCS acquisitions were made, 24 hours after two rounds of treatment with a siRNA against endogenous HSF1, followed by ...
Antoine Delon (431449), Claire Vourc’h (431448), Gaëtan Herbomel (431444), Yves Usson (431447), Eric G. Folco (310374), Catherine Souchier (431450), Meike Kloster-Landsberg (431445), Edwige Col (431446)   +7 more
core   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

The Role of HSF1 Protein in Malignant Transformation

Klinicka onkologie, 2018
The heat shock transcription factor, HSF1, is the main regulator of the proteotoxic stress response that orchestrates the adaptation of cells to stress conditions such as elevated temperature, oxidative stress, and proteotoxic stress. As such, HSF1 regulates a large number of stress response-related genes, primarily those encoding heat shock proteins ...
Oliver, Šimončík, Michal, Pastorek, Bořivoj, Vojtěšek, Petr, Müller   +3 more
openaire   +2 more sources

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source