Results 51 to 60 of about 13,686 (217)
PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element
Cells, 2022 At present, the barrier to HIV-1 functional cure is the persistence of HIV-1 reservoirs. The “shock (reversing latency) and kill (antiretroviral therapy)” strategy sheds light on reducing or eliminating the latent reservoir of HIV-1. However, the current
Xinfeng Xu +10 more
doaj +1 more source
Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively. [PDF]
PLoS ONE, 2014 Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood ...
Inbal Nussbaum +4 more
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Expression of STUB1-DN increases HSF1 activity. [PDF]
, 2019 Activation of HSF1 inhibits GOx induced sEVs secretion. ARPE-19 cells were transduced using lentiviral particles containing vectors either for the expression of wtSTUB1, STUB1K30A and STUB1H260Q or with adenoviral particles containing shRNA against STUB1.
Ana Rosa Soares (4738182) +7 more
core +1 more source
Journal of Biological Chemistry, 2011 In the recent article by Tranter et al. (1), it is indicated that homozygous Hsf1 (knock-out) mice are not viable. This information as mentioned was not supported by any reference. As statements provided in scientific papers need to be accurate, I would like to provide the following additional information and correction.
openaire +2 more sources
HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression
Reproductive Biology and Endocrinology, 2021 Background Endometriosis is a chronic hormonal inflammatory disease characterized by the presence of endometrial tissue outside the uterus. Endometriosis often causes infertility, which brings physical and mental pain to patients and their families ...
Yixin Wang +4 more
doaj +1 more source
Intracellular localization of HSF1 transcription factor in HeLa cells. [PDF]
, 2013 CLSM images of wild type HSF1-eGFP, HSF1-ΔTRIM-eGFP, HSF1-K80Q-eGFP and HSF1-ΔDBD-eGFP before (NHS) and after a one hour heat shock (HS). HSF1 is predominantly nuclear except when the trimerization domain is deleted.
Antoine Delon (431449) +7 more
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Diagnostic Pathology, 2018 Background Heat shock factor 1 (HSF1) was initially identified as a transcription factor encoding heat shock proteins, which assist in refolding or degrading damaged proteins.
Weigang Dai +10 more
doaj +1 more source
The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model. [PDF]
PLoS ONE, 2016 Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. The proteotoxic stress-responsive transcription factor HSF1 is frequently overexpressed in a variety of ...
Chase D Powell +5 more
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The SmHsf1 antibody recognizes the SmHsf1 protein. [PDF]
, 2014 Purified IgG from SmHsf1-immunized rabbit bleeds (lanes 1–4) or pre-immune serum (lane 5) were used in a Western blot to test for reactivity against bacterially expressed recombinant proteins and cercarial extract (lane 1), 1 µg MBP negative control ...
Giselle M. Knudsen (217467) +3 more
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Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing
Advanced Science, EarlyView.A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo +11 more
wiley +1 more source