Results 71 to 80 of about 20,857 (230)

Heat shock factor 1 contributes to ischemia-induced angiogenesis by regulating the mobilization and recruitment of bone marrow stem/progenitor cells. [PDF]

PLoS ONE, 2012
Bone marrow (BM)-derived stem/progenitor cells play an important role in ischemia-induced angiogenesis in cardiovascular diseases. Heat shock factor 1 (HSF1) is known to be induced in response to hypoxia and ischemia. We examined whether HSF1 contributes
Masayuki Kubo, Tao-Sheng Li, Hiroshi Kurazumi, Yoshihiro Takemoto, Mako Ohshima, Yumi Yamamoto, Arata Nishimoto, Akihito Mikamo, Mitsuaki Fujimoto, Akira Nakai, Kimikazu Hamano   +10 more
doaj   +1 more source

The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

, 2019
Misfolded proteins in the endoplasmic reticulum (ER) activate the unfolded protein response (U PR), which enhances protein folding to restore homeostasis.
Aviram, Barlowe, Berner, Bicknell, Bonilla, Boos, Bosis, Braakman, Chen, Christiano, Conz, Cox, Cox, Cox, Dohmen, Finger, Foresti, Foresti, Gasch, Gething, Goldberg, Görner, Hahn, Hahn, Hahn, Hallstrom, Hampton, Hanssum, Hao, Harbison, Higuchi-Sanabria, Hitchcock, Ho, Hou, Huebert, Itzhak, Janke, Jelinsky, Jonikas, Kawaguchi, Khmelinskii, Kim, Knop, Kostova, Leber, Lee, Liu, Longtine, Mannhaupt, Martínez-Pastor, Meiners, Metzger, Mitsiades, Mumberg, Nasmyth, Ng, Ng, Nishitoh, Obeng, Owsianik, Patil, Pincus, Pincus, Prasad, Radhakrishnan, Rapoport, Rousseau, Schuck, Sikorski, Spear, Spear, Sprouffske, Steffen, Stirling, Szoradi, Tkach, Travers, Tyanova, Verghese, Vogel, Walter, Wang, Wang, Wrobel, Xie, Yamamoto, Young, Zheng   +87 more
core   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant diseases because of its non-symptomatic tumorigenesis. We previous found heat shock factor 1 (HSF1) was critical for PDAC progression and the aim of this study was to ...
Weikun Qian, Ke Chen, Tao Qin, Ying Xiao, Jie Li, Yangyang Yue, Cancan Zhou, Jiguang Ma, Wanxing Duan, Jianjun Lei, Liang Han, Li Li, Xin Shen, Zheng Wu, Qingyong Ma, Zheng Wang   +15 more
doaj   +1 more source

The Overlooked Autoantibody Repertoire: Exploring the Biomarker Potential of Downregulated Autoantibodies in NSCLC

Cancer Science, EarlyView.
This study identifies downregulated autoantibodies in NSCLC and demonstrates their diagnostic and prognostic utility. Integrating proteome‐wide screening and large‐cohort validation, we highlight a novel biomarker class that enhances early detection and patient stratification.
Yihao Liang, Hanke Ma, Wenke Sun, Ying Chen, Fengqi Chen, Yutong Li, Songyun Ouyang, Liping Dai   +7 more
wiley   +1 more source

Candida albicans pathogenicity mechanisms [PDF]

, 2013
Peer reviewedPublisher ...
Alonso-Monge R, Braun BR, Csank C, De Bernardis F, Diez-Orejas R, Fonzi WA, Hube B, Hwang CS, Mühlschlegel FA, Sorger PK, Wysong DR   +10 more
core   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

HSF1 mediated stress response of heavy metals

PLOS ONE, 2018
The heat shock response (HSR) pathway is a highly conserved cellular stress response and mediated by its master regulator HSF1. Activation of the pathway results in the expression of chaperone proteins (heat shock proteins; HSP) to maintain protein homeostasis. One of the genes strongest upregulated upon stress is HSPA1A (HSP72).
Christoph Steurer, Noreen Eder, Sarah Kerschbaum, Christina Wegrostek, Stefan Gabriel, Natalia Pardo, Viktoria Ortner, Thomas Czerny, Elisabeth Riegel   +8 more
openaire   +3 more sources

Polymorphisms of Bovine HSP90 and Their Implications in Beef Cattle Productivity [PDF]

, 2018
Production of beef cattle represents a $60 billion industry in the United States (USDA, 2015). The American beef cattle industry loses an estimated $370 million annually due to heat stress (St-Pierre, 2003).
Smith, Glynn G
core   +2 more sources

The pause-initiation limit restricts transcription activation in human cells.

, 2019
Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II) pausing in the promoter-proximal region. Pausing Pol II limits the frequency of transcription initiation ('pause-initiation limit'), predicting that the pause ...
Cramer, P., Gressel, S., Schwalb, B.
core   +1 more source