Results 71 to 80 of about 13,686 (217)
HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation [PDF]
, 2017 Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program.
Megan L. Tigue +12 more
core +1 more source
Heat shock factor 1 contributes to ischemia-induced angiogenesis by regulating the mobilization and recruitment of bone marrow stem/progenitor cells. [PDF]
PLoS ONE, 2012 Bone marrow (BM)-derived stem/progenitor cells play an important role in ischemia-induced angiogenesis in cardiovascular diseases. Heat shock factor 1 (HSF1) is known to be induced in response to hypoxia and ischemia. We examined whether HSF1 contributes
Masayuki Kubo +10 more
doaj +1 more source
Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer
Medicinal Research Reviews, EarlyView.ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek +3 more
wiley +1 more source
A schematic presentations of the various Hsf1 activation pathways. [PDF]
, 2014 The three stresses, heat shock, oxidative stress and sugar starvation, activate the inactive Hsf1 through different mediators, Sir2, Yap1 and Snf1, respectively.
Esther Weindling (651935) +4 more
core +1 more source
Yeast, EarlyView.ABSTRACT All organisms must be able to sense and respond to adverse environments, especially those that threaten cellular integrity. The age of genomics clarified the breadth and specificity of cellular stress responses, including in free‐living microbes directly exposed to a changing environment.
Audrey P. Gasch
wiley +1 more source
Role of HSF1 expression for tumor microenvironment in intrahepatic cholangiocarcinoma. [PDF]
, 2017 249 Background: Heat shock factor 1 (HSF1) is a master regulator of heat shock response. HSF1 is recently identified to play a multifaceted role in cancer progression.
Mitsuo Shimada +7 more
core +1 more source
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract The biogeography of ectotherms is greatly influenced by their thermal tolerance, which is expected to be tightly coupled to aerobic performance. However, preferred temperatures of ectotherms often deviate substantially from aerobic performance optima. This suggests that
Analisa Lazaro‐Côté +6 more
wiley +1 more source
Investigating the HSF1-HSF2 Interaction [PDF]
, 2017 The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a cell, a class of proteins known
Jaeger, Alex +2 more
core
The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer
Journal of Experimental & Clinical Cancer Research, 2021 Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant diseases because of its non-symptomatic tumorigenesis. We previous found heat shock factor 1 (HSF1) was critical for PDAC progression and the aim of this study was to ...
Weikun Qian +15 more
doaj +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, EarlyView.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source