The Emerging Role of Heat Shock Factor 1 (HSF1) and Heat Shock Proteins (HSPs) in Ferroptosis [PDF]
Pathophysiology, 2023 Cells employ a well-preserved physiological stress response mechanism, termed the heat shock response, to activate a certain type of molecular chaperone called heat shock proteins (HSPs).
Iman Aolymat +2 more
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Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response [PDF]
Cell Reports, 2023 Summary: Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts ...
Meng Xu +8 more
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Diversification of the Caenorhabditis heat shock response by Helitron transposable elements [PDF]
eLife, 2019 Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression of genes important for cellular protection during this stress ...
Jacob M Garrigues +3 more
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Proteotoxic stress response in atherosclerotic cardiovascular disease: Emerging role of heat shock factor 1 [PDF]
Frontiers in Cardiovascular Medicine, 2023 Atherosclerosis is a major risk factor for cardiovascular diseases. Hypercholesterolemia has been both clinically and experimentally linked to cardiovascular disease and is involved in the initiation of atherosclerosis.
Shruti Ghai, Alex Young, Kuo-Hui Su
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Heat shock factor-1 alleviates ER-stress in Caenorhabditis elegans [PDF]
Scientific ReportsCells can be exposed to many different stimuli that induce a variety of stresses, such as oxidative stress and proteotoxic stress of the cytoplasm, endoplasmic reticulum or mitochondria. These types of stresses trigger conserved molecular pathways (e.g.,
Saqib Ahmed +12 more
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Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease [PDF]
Cell Reports, 2023 Summary: p53 and HSF1 are two major transcription factors involved in cell proliferation and apoptosis, whose dysregulation contributes to cancer and neurodegeneration.
Rachel H. Mansky +9 more
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Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation [PDF]
Nature Communications, 2023 The survival of malignant tumors is highly dependent on their intrinsic self-defense pathways such as heat shock protein (HSP) during cancer therapy. However, precisely dismantling self-defenses to amplify antitumor potency remains unexplored. Herein, we
Ting Li +9 more
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Heat Shock Factor 1 Prevents Age-Related Hearing Loss by Decreasing Endoplasmic Reticulum Stress [PDF]
Cells, 2021 Endoplasmic reticulum (ER) stress is a common stress factor during the aging process. Heat shock factor 1 (HSF1) plays a critical role in ER stress; however, its exact function in age-related hearing loss (ARHL) has not been fully elucidated. The purpose
Yun Yeong Lee +5 more
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Heat Shock Factor 1 as a Prognostic and Diagnostic Biomarker of Gastric Cancer [PDF]
Biomedicines, 2021 Identification of effective prognostic and diagnostic biomarkers is needed to improve the diagnosis and treatment of gastric cancer. Early detection of gastric cancer through diagnostic markers can help establish effective treatments. Heat shock factor 1
Woong Kim, Seok-Jun Kim
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Heat shock factor 1 is a direct anti-amyloid factor: connecting neurodegeneration and uncontrolled growth [PDF]
Neural Regeneration Research, 2022 Zijian Tang, Chengkai Dai
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