Heat shock factor 1 is a direct anti-amyloid factor: connecting neurodegeneration and uncontrolled growth [PDF]
Neural Regeneration Research, 2022 Zijian Tang, Chengkai Dai
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Discovery of Disubstituted Carboranes as Inhibitors of Heat Shock Protein 90-Heat Shock Factor 1 Interaction. [PDF]
ACS Med Chem LettEfficient synthesis of disubstituted para- and ortho-carboranes (2 and 3, respectively) was achieved. Among the compounds synthesized, 3e showed potent suppression of hypoxia-inducible factor 1 (HIF-1) transcriptional activity under hypoxia by a cell-based reporter gene assay.
Shao Y +5 more
europepmc +3 more sources
Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response [PDF]
European Journal of Immunology, 2003 AbstractThe induction of heat shock proteins by heat shock is classically defined as the heat shock response, which is involved in cytoprotection, inflammation and immune responses. Whereas the cytoprotective properties of heat shock have been well characterized, the immunomodulating roles of the heat shock response on the immune system are just ...
Hong, Zheng +3 more
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Mechanistic Insights Into Oxidative Response of Heat Shock Factor 1 Condensates [PDF]
JACS AuSoichiro Kawagoe +6 more
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Correction: Heat shock factor-1 alleviates ER-stress in Caenorhabditis elegans [PDF]
Scientific ReportsSaqib Ahmed +12 more
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Transcription factor cooperativity with heat shock factor 1 [PDF]
Transcription, 2011 The heat shock response has been characterized by the induction of major heat shock proteins that suppress protein aggregation by facilitating protein folding. Recently, we found that mammalian heat shock factor 1, a master regulator of HSP genes, regulates non-HSP genes that suppress protein aggregation by controlling protein degradation in ...
Naoki, Hayashida +2 more
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Regulation of the mammalian heat shock factor 1 [PDF]
The FEBS Journal, 2017 Living organisms are endowed with the capability to tackle various forms of cellular stress due to the presence of molecular chaperone machinery complexes that are ubiquitous throughout the cell. During conditions of proteotoxic stress, the transcription factor heat shock factor 1 (HSF1) mediates the elevation of heat shock proteins, which are crucial ...
Dayalan Naidu, Sharadha +1 more
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Heat Shock-Independent Induction of Multidrug Resistance by Heat Shock Factor 1 [PDF]
Molecular and Cellular Biology, 2006 The screening of two different retroviral cDNA expression libraries to select genes that confer constitutive doxorubicin resistance has in both cases resulted in the isolation of the heat shock factor 1 (HSF1) transcription factor. We show that HSF1 induces a multidrug resistance phenotype that occurs in the absence of heat shock or cellular stress and
Thierry, Tchénio +3 more
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Is there a role for HSF1 in viral infections?
FEBS Open Bio, 2022 Cells undergo numerous processes to adapt to new challenging conditions and stressors. Heat stress is regulated by a family of heat shock factors (HSFs) that initiate a heat shock response by upregulating the expression of heat shock proteins (HSPs ...
Antonia Reyes +4 more
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AIRAP, a New Human Heat Shock Gene Regulated by Heat Shock Factor 1 [PDF]
Journal of Biological Chemistry, 2010 Heat shock factor-1 (HSF1) is the central regulator of heat-induced transcriptional responses leading to rapid expression of molecular chaperones that protect mammalian cells against proteotoxic stress. The main targets for HSF1 are specific promoter elements (HSE) located upstream of heat shock genes encoding a variety of heat shock proteins ...
ROSSI, ANTONELLO +5 more
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