Results 11 to 20 of about 543,466 (295)
Transcription regulation of HYPK by Heat Shock Factor 1. [PDF]
PLoS ONE, 2014 HYPK (Huntingtin Yeast Partner K) was originally identified by yeast two-hybrid assay as an interactor of Huntingtin, the protein mutated in Huntington's disease.
Srijit Das, Nitai Pada Bhattacharyya
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Regulation of the mammalian heat shock factor 1 [PDF]
The FEBS Journal, 2017 Living organisms are endowed with the capability to tackle various forms of cellular stress due to the presence of molecular chaperone machinery complexes that are ubiquitous throughout the cell. During conditions of proteotoxic stress, the transcription
Dayalan Naidu, Sharadha +1 more
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Protein kinase A binds and activates heat shock factor 1. [PDF]
PLoS ONE, 2010 Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli.
Ayesha Murshid +5 more
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Mechanistic Insights Into Oxidative Response of Heat Shock Factor 1 Condensates [PDF]
JACS AuSoichiro Kawagoe +6 more
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Transcription factor cooperativity with heat shock factor 1 [PDF]
Transcription, 2011 The heat shock response has been characterized by the induction of major heat shock proteins that suppress protein aggregation by facilitating protein folding. Recently, we found that mammalian heat shock factor 1, a master regulator of HSP genes, regulates non-HSP genes that suppress protein aggregation by controlling protein degradation in ...
Naoki, Hayashida +2 more
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Heat Shock-Independent Induction of Multidrug Resistance by Heat Shock Factor 1 [PDF]
Molecular and Cellular Biology, 2006 The screening of two different retroviral cDNA expression libraries to select genes that confer constitutive doxorubicin resistance has in both cases resulted in the isolation of the heat shock factor 1 (HSF1) transcription factor. We show that HSF1 induces a multidrug resistance phenotype that occurs in the absence of heat shock or cellular stress and
Thierry, Tchénio +3 more
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Is there a role for HSF1 in viral infections?
FEBS Open Bio, 2022 Cells undergo numerous processes to adapt to new challenging conditions and stressors. Heat stress is regulated by a family of heat shock factors (HSFs) that initiate a heat shock response by upregulating the expression of heat shock proteins (HSPs ...
Antonia Reyes +4 more
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Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells [PDF]
Molecular Biology of the Cell, 2009 A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation.
Fritah, Sabrina +9 more
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AIRAP, a New Human Heat Shock Gene Regulated by Heat Shock Factor 1 [PDF]
Journal of Biological Chemistry, 2010 Heat shock factor-1 (HSF1) is the central regulator of heat-induced transcriptional responses leading to rapid expression of molecular chaperones that protect mammalian cells against proteotoxic stress. The main targets for HSF1 are specific promoter elements (HSE) located upstream of heat shock genes encoding a variety of heat shock proteins ...
ROSSI, ANTONELLO +5 more
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Intramolecular Repression of Mouse Heat Shock Factor 1 [PDF]
Molecular and Cellular Biology, 1998 The pathway leading to transcriptional activation of heat shock genes involves a step of heat shock factor 1 (HSF1) trimerization required for high-affinity binding of this activator protein to heat shock elements (HSEs) in the promoters. Previous studies have shown that in vivo the trimerization is negatively regulated at physiological temperatures by
T, Farkas, Y A, Kutskova, V, Zimarino
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