Results 21 to 30 of about 543,466 (295)

Heat Shock Factor 1 Mediates Latent HIV Reactivation [PDF]

Scientific Reports, 2016
AbstractHSF1, a conserved heat shock factor, has emerged as a key regulator of mammalian transcription in response to cellular metabolic status and stress. To our knowledge, it is not known whether HSF1 regulates viral transcription, particularly HIV-1 and its latent form.
Xiao-Yan Pan, Wei Zhao, Xiao-Yun Zeng, Jian Lin, Min-Min Li, Xin-Tian Shen, Shu-Wen Liu   +6 more
openaire   +2 more sources

CHIP interacts with heat shock factor 1 during heat stress [PDF]

FEBS Letters, 2005
Heat shock factor 1 (HSF1) is a major transactivator of heat shock genes in response to stress and mediates cell protection against various harmful conditions. In this study, we identified the interaction of CHIP (carboxyl terminus of the heat shock cognate protein 70‐interacting protein) with the N‐terminus of HSF1. Using GST full‐down assay, we found
Kim, Soo-A, Yoon, Jung-Hoon, Kim, Do-Kyung, Kim, Su-Gwan, Ahn, Sang-Gun   +4 more
openaire   +2 more sources

Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans [PDF]

, 2019
Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose
daeeun jeong, dongyeop lee, Eunseok choi, Jang, SK, Lee, SJ, Seo, K   +5 more
core   +1 more source

Interaction between Arabidopsis heat shock transcription factor 1 and 70 kDa heat shock proteins [PDF]

Journal of Experimental Botany, 2002
The activity of the Arabidopsis heat shock transcription factor (HSF) is repressed at normal conditions but activated by cellular stresses. Circumstantial evidence suggests that HSP70 may function as a negative feedback regulator of HSF activity. Here the interaction between HSF and HSP70 is reported using electrophoretic mobility shift and yeast two ...
Byung-Hoon, Kim, Fritz, Schöffl
openaire   +2 more sources

Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci Upon Heat Shock [PDF]

Cell Reports, 2018
ABSTRACTTranscriptional induction ofHeat Shock Protein(HSP) genes in yeast is accompanied by dynamic changes in their 3D structure and spatial organization, yet the molecular basis for these phenomena remains unknown. Using chromosome conformation capture and single cell imaging, we show that genes transcriptionally activated by Heat Shock Factor 1 ...
Chowdhary, Surabhi, Kainth, Amoldeep S., Pincus, David, Gross, David S.   +3 more
openaire   +2 more sources

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]

, 2008
Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano, Borkowski, Andrew W., Heppner, Frank L., Hutter, Gregor, Jackson, Walter S., King, Oliver D., Lindquist, Susan, Raymond, Gregory J., Steele, Andrew D.   +8 more
core   +3 more sources

Immunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activator. [PDF]

PLoS Neglected Tropical Diseases, 2014
Schistosomiasis is a chronically debilitating disease caused by parasitic worms of the genus Schistosoma, and it is a global problem affecting over 240 million people.
Kenji Ishida, Melissa Varrecchia, Giselle M Knudsen, Emmitt R Jolly   +3 more
doaj   +1 more source

Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels

Cancer Biology & Medicine, 2019
Objective Heat shock factor 1 (HSF1), a transcriptional regulator of heat shock proteins (HSPs), is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have been identified so far.Methods The mRNA and protein levels of HSF1 ...
Na Li, Ting Wang, Zongmeng Li, Xiaoli Ye, Bo Deng, Shu Zhuo, Pengle Yao, Mengmei Yang, Hong Mei, Xiaofang Chen, Tengfei Zhu, Shiting Chen, Hui Wang, Jiming Wang, Yingying Le   +14 more
doaj   +1 more source

Aneuploidy and proteotoxic stress in cancer [PDF]

, 2015
Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between ...
Donnelly, N., Storchova, Z.
core   +2 more sources

Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Journal of Inflammation, 2011
Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine ...
Zingarelli Basilia, Gefter Julia V, Sjodin Hanna, Aneja Rajesh K, Delude Russell L   +4 more
doaj   +1 more source