Results 21 to 30 of about 198,478 (151)
Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells [PDF]
Molecular Biology of the Cell, 2009 A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation.
Fritah, Sabrina +9 more
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Intramolecular Repression of Mouse Heat Shock Factor 1 [PDF]
Molecular and Cellular Biology, 1998 The pathway leading to transcriptional activation of heat shock genes involves a step of heat shock factor 1 (HSF1) trimerization required for high-affinity binding of this activator protein to heat shock elements (HSEs) in the promoters. Previous studies have shown that in vivo the trimerization is negatively regulated at physiological temperatures by
T, Farkas, Y A, Kutskova, V, Zimarino
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Activation of Heat Shock Transcription Factor 1 in Atherosclerosis [PDF]
The American Journal of Pathology, 2003 Previous work established that increased expression of heat shock proteins (HSPs) in the vessel wall might evoke proinflammatory and autoimmune reactions in the pathogenesis of atherosclerosis. The present study was designed to further scrutinize the molecular mechanisms of HSP expression involving activation of heat shock transcription factors (HSFs ...
Bernhard, Metzler +6 more
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Therapeutic Influence of Exosomes Derived from Non-heat versus Heat Shocked Stem Cells on Experimentally Induced Myocardial Infarction in Adult Male Albino Rats [PDF]
The Egyptian Journal of Histology, 2021 Background: Worldwide, myocardial infarction (MI) is considered as a principal cause of mortality. It results in death of the cardiac myocytes and declining of the cardiac functions.
Marwa Yousry, Abeer Omar
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CHIP interacts with heat shock factor 1 during heat stress [PDF]
FEBS Letters, 2005 Heat shock factor 1 (HSF1) is a major transactivator of heat shock genes in response to stress and mediates cell protection against various harmful conditions. In this study, we identified the interaction of CHIP (carboxyl terminus of the heat shock cognate protein 70‐interacting protein) with the N‐terminus of HSF1. Using GST full‐down assay, we found
Kim, Soo-A +4 more
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Cancer Biology & Medicine, 2019 Objective Heat shock factor 1 (HSF1), a transcriptional regulator of heat shock proteins (HSPs), is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have been identified so far.Methods The mRNA and protein levels of HSF1 ...
Na Li +14 more
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Heat-shock cognate 70 is required for the activation of heat-shock factor 1 in mammalian cells [PDF]
Biochemical Journal, 2005 HSF1 (heat-shock factor 1) plays an essential role in mediating the appropriate cellular response to diverse forms of physiological stresses. However, it is not clear how HSF1 is regulated by interacting proteins under normal and stressful conditions. In the present study, Hsc70 (heat-shock cognate 70) was identified as a HSF1-interacting protein using
Sang-Gun, Ahn +3 more
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Journal of Inflammation, 2011 Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine ...
Zingarelli Basilia +4 more
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Immunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activator. [PDF]
PLoS Neglected Tropical Diseases, 2014 Schistosomiasis is a chronically debilitating disease caused by parasitic worms of the genus Schistosoma, and it is a global problem affecting over 240 million people.
Kenji Ishida +3 more
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Heat Shock Factor 1 Is a Transcription Factor of Fas Gene
Molecules and Cells, 2010 In mammalian cells, stress-induced expression of heat shock protein is controlled by heat shock factor 1 (HSF1). However, HSF1 functions as a regulator of additional genes. In this study, we observed that heat treatment effectively induced expression of Fas.
E, Shunmei +6 more
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