Results 41 to 50 of about 198,852 (250)

Hspb1 inhibits microglial ferroptosis and pro-inflammatory activation to alleviate cerebral ischemia/reperfusion injury in mice

Neural Regeneration Research
Heat shock protein beta-1 may be involved in regulating ferroptosis in cells. The expression of heat shock protein beta-1 is upregulated after stroke; however, the underlying mechanism of action of heat shock protein beta-1 in cerebral ischemia ...
Weilong Hua, Hongye Xu, Rundong Chen, Yiyong Zeng, Lei Zhang, Yongxin Zhang, Xiaoxi Zhang, Yongwei Zhang, Hongjian Zhang, Jianmin Liu, Pengfei Yang   +10 more
doaj   +1 more source

Comparative modeling and mutual docking of structurally uncharacterized heat shock protein 70 and heat shock factor-1 proteins in water buffalo [PDF]

Veterinary World, 2019
Aim: In this study, a wide range of in silico investigation of Bubalus bubalis (BB) heat shock protein 70 (HSP70) and heat shock factor-1 (HSF1) has been performed, ranging from sequence evaluation among species to homology modeling along with their ...
Ravinder Singh, Ankita Gurao, C. Rajesh, S. K. Mishra, Saroj Rani, Ankita Behl, Vikash Kumar, R. S. Kataria   +7 more
doaj   +1 more source

Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation [PDF]

Cell Stress & Chaperones, 2004
Transcription of mammalian heat shock genes can be regulated by heat shock factors (HSF) 1 and 2. Although it has been shown previously that these factors respond to distinct stimuli, a broad analysis of the induction and function of these factors in living cells has not been performed.
Nathan D, Trinklein, Will C, Chen, Robert E, Kingston, Richard M, Myers   +3 more
openaire   +3 more sources

Diversification of the Caenorhabditis heat shock response by Helitron transposable elements

eLife, 2019
Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression of genes important for cellular protection during this stress ...
Jacob M Garrigues, Brian V Tsu, Matthew D Daugherty, Amy E Pasquinelli   +3 more
doaj   +1 more source

Temporal requirements of heat shock factor‐1 for longevity assurance [PDF]

Aging Cell, 2012
SummaryReducing the activity of the insulin/IGF‐1 signaling pathway (IIS) modifies development, elevates stress resistance, protects from toxic protein aggregation (proteotoxicity), and extends lifespan (LS) of worms, flies, and mice. In the nematode Caenorhabditis elegans, LS extension by IIS reduction is entirely dependent upon the activity of the ...
Yuli, Volovik, Moria, Maman, Tatyana, Dubnikov, Michal, Bejerano-Sagie, Derek, Joyce, Erik A, Kapernick, Ehud, Cohen, Andrew, Dillin   +7 more
openaire   +2 more sources

Possible Involvement of HSP90-HSF1 Multichaperone Complex in Impairment of HSP72 Induction in the Failing Heart Following Myocardial Infarction in Rats

Journal of Pharmacological Sciences, 2013
It is generally accepted that an increase in the myocardial level of heat-shock protein 72 (HSP72) protects viable cardiac tissue against myocardial infarction (MI)-induced stress.
Tetsuro Marunouchi, Masato Araki, Mao Murata, Norio Takagi, Kouichi Tanonaka   +4 more
doaj   +1 more source

HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity

Cells, 2020
Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for responding to proteotoxic stress and involves the rapid expression of heat ...
Thomas L. Prince, Benjamin J. Lang, Martin E. Guerrero-Gimenez, Juan Manuel Fernandez-Muñoz, Andrew Ackerman, Stuart K. Calderwood   +5 more
doaj   +1 more source

Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response

Pharmaceutical Biology, 2022
Context Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs).
Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han   +7 more
doaj   +1 more source

Heat shock factor 1 is inactivated by amino acid deprivation [PDF]

Cell Stress and Chaperones, 2012
Mammalian cells respond to a lack of amino acids by activating a transcriptional program with the transcription factor ATF4 as one of the main actors. When cells are faced with cytoplasmic proteotoxic stress, a quite different transcriptional response is mounted, the heat shock response, which is mediated by HSF1.
Hensen, S.M.M., Heldens, L., Enckevort, C.M.W. van, Genesen, S.T. van, Pruijn, G.J.M., Lubsen, N.H.   +5 more
openaire   +3 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source