Hyperthermia Stress Activates Heat Shock Protein Expression via Propyl Isomerase 1 Regulation with Heat Shock Factor 1 [PDF]
Molecular and Cellular Biology, 2013 Heat shock proteins (HSPs), which are members of the chaperone family of proteins, are essential factors for cellular responses to environmental stressors, such as hyperthermia, and are antiapoptotic. The transcription of HSPs is mainly controlled by heat shock transcription factor 1 (HSF1).
Hsiu-Yu, Wang +3 more
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Tracking the Activation of Heat Shock Signaling in Cellular Protection and Damage
Cells, 2022 Heat Shock (HS) signaling is activated in response to various types of cellular stress. This activation serves to protect cells from immediate threats in the surrounding environment.
Shisui Torii, Pasko Rakic
doaj +1 more source
Oxidative phase transition of heat shock factor-1 [PDF]
, 2021 ABSTRACTHeat shock factor 1 (Hsf1) was found as a central upregulator of molecular chaperones in stress adaptation, but it has recently been rediscovered as a major component of persistent nuclear stress bodies (nSBs). When the persistently stressed cells undergo apoptosis, the phase transition of nSBs from fluid to gel-like states is proposed to be an
Soichiro Kawagoe +3 more
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Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis [PDF]
, 2012 Intrinsic stress response pathways are frequently mobilized within tumor cells. The mediators of these adaptive mechanisms and how they contribute to carcinogenesis remain poorly understood.
Alessi +19 more
core +1 more source
Discovery of Disubstituted Carboranes as Inhibitors of Heat Shock Protein 90-Heat Shock Factor 1 Interaction. [PDF]
ACS Med Chem LettEfficient synthesis of disubstituted para- and ortho-carboranes (2 and 3, respectively) was achieved. Among the compounds synthesized, 3e showed potent suppression of hypoxia-inducible factor 1 (HIF-1) transcriptional activity under hypoxia by a cell-based reporter gene assay.
Shao Y +5 more
europepmc +3 more sources
Cosmological Effects of Powerful AGN Outbursts in Galaxy Clusters: Insights from an XMM-Newton Observation of MS0735+7421 [PDF]
, 2006 We report on the results of an analysis of XMM-Newton observations of MS0735+7421, the galaxy cluster which hosts the most energetic AGN outburst currently known.
B. R. McNamara +13 more
core +2 more sources
Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update [PDF]
Archives of Toxicology, 2012 Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their rapid and abundant induction by stress. HSP genes are activated at the transcriptional level by heat shock transcription factor 1 (HSF1). During the progression of many types of cancer, this heat shock transcriptional regulon becomes co-opted by mechanisms that are
Ciocca, Daniel Ramon +2 more
openaire +3 more sources
Host proteostasis modulates influenza evolution
eLife, 2017 Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens.
Angela M Phillips +9 more
doaj +1 more source
Comparative modeling and mutual docking of structurally uncharacterized heat shock protein 70 and heat shock factor-1 proteins in water buffalo [PDF]
Veterinary World, 2019 Aim: In this study, a wide range of in silico investigation of Bubalus bubalis (BB) heat shock protein 70 (HSP70) and heat shock factor-1 (HSF1) has been performed, ranging from sequence evaluation among species to homology modeling along with their ...
Ravinder Singh +7 more
doaj +1 more source
The influence of potassium on core and geodynamo evolution [PDF]
, 2004 We model the thermal evolution of the core and mantle using a parametrized convection scheme, and calculate the entropy available to drive the geodynamo as a function of time.
Abramowitz +19 more
core +1 more source