Results 41 to 50 of about 198,478 (151)

Comparative modeling and mutual docking of structurally uncharacterized heat shock protein 70 and heat shock factor-1 proteins in water buffalo [PDF]

Veterinary World, 2019
Aim: In this study, a wide range of in silico investigation of Bubalus bubalis (BB) heat shock protein 70 (HSP70) and heat shock factor-1 (HSF1) has been performed, ranging from sequence evaluation among species to homology modeling along with their ...
Ravinder Singh, Ankita Gurao, C. Rajesh, S. K. Mishra, Saroj Rani, Ankita Behl, Vikash Kumar, R. S. Kataria   +7 more
doaj   +1 more source

Temporal requirements of heat shock factor‐1 for longevity assurance [PDF]

Aging Cell, 2012
SummaryReducing the activity of the insulin/IGF‐1 signaling pathway (IIS) modifies development, elevates stress resistance, protects from toxic protein aggregation (proteotoxicity), and extends lifespan (LS) of worms, flies, and mice. In the nematode Caenorhabditis elegans, LS extension by IIS reduction is entirely dependent upon the activity of the ...
Yuli, Volovik, Moria, Maman, Tatyana, Dubnikov, Michal, Bejerano-Sagie, Derek, Joyce, Erik A, Kapernick, Ehud, Cohen, Andrew, Dillin   +7 more
openaire   +2 more sources

Diversification of the Caenorhabditis heat shock response by Helitron transposable elements

eLife, 2019
Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression of genes important for cellular protection during this stress ...
Jacob M Garrigues, Brian V Tsu, Matthew D Daugherty, Amy E Pasquinelli   +3 more
doaj   +1 more source

Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response

Pharmaceutical Biology, 2022
Context Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs).
Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han   +7 more
doaj   +1 more source

Possible Involvement of HSP90-HSF1 Multichaperone Complex in Impairment of HSP72 Induction in the Failing Heart Following Myocardial Infarction in Rats

Journal of Pharmacological Sciences, 2013
It is generally accepted that an increase in the myocardial level of heat-shock protein 72 (HSP72) protects viable cardiac tissue against myocardial infarction (MI)-induced stress.
Tetsuro Marunouchi, Masato Araki, Mao Murata, Norio Takagi, Kouichi Tanonaka   +4 more
doaj   +1 more source

Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation [PDF]

Cell Stress & Chaperones, 2004
Transcription of mammalian heat shock genes can be regulated by heat shock factors (HSF) 1 and 2. Although it has been shown previously that these factors respond to distinct stimuli, a broad analysis of the induction and function of these factors in living cells has not been performed.
Nathan D, Trinklein, Will C, Chen, Robert E, Kingston, Richard M, Myers   +3 more
openaire   +3 more sources

HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity

Cells, 2020
Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for responding to proteotoxic stress and involves the rapid expression of heat ...
Thomas L. Prince, Benjamin J. Lang, Martin E. Guerrero-Gimenez, Juan Manuel Fernandez-Muñoz, Andrew Ackerman, Stuart K. Calderwood   +5 more
doaj   +1 more source

Heat shock factor 1 is inactivated by amino acid deprivation [PDF]

Cell Stress and Chaperones, 2012
Mammalian cells respond to a lack of amino acids by activating a transcriptional program with the transcription factor ATF4 as one of the main actors. When cells are faced with cytoplasmic proteotoxic stress, a quite different transcriptional response is mounted, the heat shock response, which is mediated by HSF1.
Hensen, S.M.M., Heldens, L., Enckevort, C.M.W. van, Genesen, S.T. van, Pruijn, G.J.M., Lubsen, N.H.   +5 more
openaire   +3 more sources

Discovery of Disubstituted Carboranes as Inhibitors of Heat Shock Protein 90-Heat Shock Factor 1 Interaction. [PDF]

ACS Med Chem Lett
Efficient synthesis of disubstituted para- and ortho-carboranes (2 and 3, respectively) was achieved. Among the compounds synthesized, 3e showed potent suppression of hypoxia-inducible factor 1 (HIF-1) transcriptional activity under hypoxia by a cell-based reporter gene assay.
Shao Y, Miura K, Asawa Y, Morita T, Li G, Nakamura H.   +5 more
europepmc   +3 more sources

Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis [PDF]

Cell, 2007
Heat shock factor 1 (HSF1) is the master regulator of the heat shock response in eukaryotes, a very highly conserved protective mechanism. HSF1 function increases survival under a great many pathophysiological conditions. How it might be involved in malignancy remains largely unexplored. We report that eliminating HSF1 protects mice from tumors induced
Dai, C, Whitesell, L, Rogers, A B, Lindquist, S   +3 more
openaire   +3 more sources