Results 61 to 70 of about 198,478 (151)

The Role of Heat Shock Transcription Factor 1 in the Genome-wide Regulation of the Mammalian Heat Shock Response [PDF]

Molecular Biology of the Cell, 2004
Previous work has implicated heat shock transcription factor 1 (HSF1) as the primary transcription factor responsible for the transcriptional response to heat stress in mammalian cells. We characterized the heat shock response of mammalian cells by measuring changes in transcript levels and assaying binding of HSF1 to promoter regions for candidate ...
Nathan D, Trinklein, John I, Murray, Sara J, Hartman, David, Botstein, Richard M, Myers   +4 more
openaire   +2 more sources

Targeting prominin2 transcription to overcome ferroptosis resistance in cancer

EMBO Molecular Medicine, 2021
Understanding how cancer cells resist ferroptosis is a significant problem that impacts ongoing efforts to stimulate ferroptosis as a therapeutic strategy.
Caitlin W Brown, Peter Chhoy, Dimpi Mukhopadhyay, Emmet R Karner, Arthur M Mercurio   +4 more
doaj   +1 more source

Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis

Journal of Experimental & Clinical Cancer Research, 2017
Background As a relatively conservative transcriptional regulator in biological evolution, heat shock factor 1 (HSF1) is activated by, and regulates the expression of heat shock proteins (HSPs) in response to a variety of stress conditions.
Wenjin Liang, Yong Liao, Jing Zhang, Qi Huang, Wei Luo, Jidong Yu, Jianhua Gong, Yi Zhou, Xuan Li, Bo Tang, Songqing He, Jinghong Yang   +11 more
doaj   +1 more source

The membrane-associated transient receptor potential vanilloid channel is the central heat shock receptor controlling the cellular heat shock response in epithelial cells. [PDF]

PLoS ONE, 2013
The heat shock response (HSR) is a highly conserved molecular response to various types of stresses, including heat shock, during which heat-shock proteins (Hsps) are produced to prevent and repair damages in labile proteins and membranes.
Zohar Bromberg, Pierre Goloubinoff, Younousse Saidi, Yoram George Weiss   +3 more
doaj   +1 more source

Interaction between Arabidopsis heat shock transcription factor 1 and 70 kDa heat shock proteins [PDF]

Journal of Experimental Botany, 2002
The activity of the Arabidopsis heat shock transcription factor (HSF) is repressed at normal conditions but activated by cellular stresses. Circumstantial evidence suggests that HSP70 may function as a negative feedback regulator of HSF activity. Here the interaction between HSF and HSP70 is reported using electrophoretic mobility shift and yeast two ...
Byung-Hoon, Kim, Fritz, Schöffl
openaire   +2 more sources

Heat shock factor 1‐independent activation of dendritic cells by heat shock: implication for the uncoupling of heat‐mediated immunoregulation from the heat shock response [PDF]

European Journal of Immunology, 2003
AbstractThe induction of heat shock proteins by heat shock is classically defined as the heat shock response, which is involved in cytoprotection, inflammation and immune responses. Whereas the cytoprotective properties of heat shock have been well characterized, the immunomodulating roles of the heat shock response on the immune system are just ...
Hong, Zheng, Ivor J, Benjamin, Sreyashi, Basu, Zihai, Li   +3 more
openaire   +2 more sources

RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress

BMC Biology, 2019
Background Adaptive responses to stress are essential for cell and organismal survival. In metazoans, little is known about the impact of environmental stress on RNA homeostasis.
Cheng-Wei Wu, Keon Wimberly, Adele Pietras, William Dodd, M. Blake Atlas, Keith P. Choe   +5 more
doaj   +1 more source

Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy

Haematologica, 2011
Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano, Giorgio Malpeli, Orah S. Platt, Christophe Lebouef, Anne Janin, Aldo Scarpa, Oliviero Olivieri, Eliana Amato, Roberto Corrocher, Yves Beuzard, Lucia De Franceschi   +10 more
doaj   +1 more source

Heat Shock Factor 1 Inhibition: A Novel Anti-Cancer Strategy with Promise for Precision Oncology. [PDF]

Cancers (Basel), 2023
Gumilar KE, Chin Y, Ibrahim IH, Tjokroprawiro BA, Yang JY, Zhou M, Gassman NR, Tan M.   +7 more
europepmc   +1 more source

Effect of N-acetyl cysteine on productive performance, biochemical indicators, mRNA expression of growth, antioxidant and heat shock protein related genes and hepatic morphology in broilers under heat stress

Poultry Science
Poultry farmers in tropical, subtropical, and temperate climates have challenges due to heat stress caused by heat waves. Egypt's already dry climate will become even more severe due to climate change.
Amal M. EL-Barbary, Amany A. El-Sahn, Eman A. Manaa, Ayman Khalifah, Asmaa Aboelnour, Ayham Abdulkader, Ayman E. Taha, Mahmoud Alagawany, Mervat A. Abdel-Latif   +8 more
doaj   +1 more source