Results 71 to 80 of about 543,466 (295)

A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions. [PDF]

PLoS ONE, 2009
BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown.
Umashankar Singh, Erik Bongcam-Rudloff, Bengt Westermark   +2 more
doaj   +1 more source

The CBP-1/p300 Lysine Acetyltransferase Regulates the Heat Shock Response in C. elegans

Frontiers in Aging, 2022
The decline of proteostasis is a hallmark of aging that is, in part, affected by the dysregulation of the heat shock response (HSR), a highly conserved cellular response to proteotoxic stress in the cell. The heat shock transcription factor HSF-1 is well-
Lindsey N. Barrett, Sandy D. Westerheide
doaj   +1 more source

Heat shock transcription factor 1 preserves cardiac angiogenesis and adaptation during pressure overload [PDF]

, 2008
To examine how heat shock transcription factor 1 (HSF1) protects against maladaptive hypertrophy during pressure overload, we subjected HSF1 transgenic (TG), knockout (KO) and wild type (WT) mice to a constriction of transverse aorta (TAC), and found ...
Aijun Sun, Aili Guan, Akira Nakai, Hong Jiang, Hong Ma, Hui Gong, Issei Komuro, Jie Yuan, Jiming Li, Junbo Ge, Lingyan Yuan, Ning Zhou, Yanyan Liang, Yuhong Niu, Yunzeng Zou, Yuqi Wang, Zhen Ma   +16 more
core   +1 more source

Heat and Hypoxic Acclimation Increase Monocyte Heat Shock Protein 72 but Do Not Attenuate Inflammation following Hypoxic Exercise [PDF]

, 2017
Acclimation to heat or hypoxic stress activates the heat shock response and accumulation of cytoprotective heat shock proteins (HSPs). By inhibiting the NF-κB pathway HSP72 can preserve epithelial function and reduce systemic inflammation.
Ahn, Arieli, Assayag, Assayag, Benjamini, Borg, Bouchama, Bruns, Carey, Caris, Castle, Colquhoun, de Castro Magalhães, Debevec, Debevec, Derikx, Dill, Dokladny, Durnin, Eltzschig, Garrett, Ghosh, Gibson, Gibson, Gibson, Horowitz, Horowitz, Horowitz, Horowitz, Kalson, Kim, Krause, Kuennen, Kukreja, Lee, Lee, Lee, Lee, Leon, Levine, Loshbaugh, March, McClung, Mekjavic, Ohri, Pandolf, Pialoux, Pires, Pugh, Ribeil, Ribeil, Sawka, Selkirk, Sessions, Shein, Shiota, Taylor, Taylor, Taylor, Vogt, Wang, White, Yacobi, Young, Zuhl, Zuhl   +65 more
core   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Physiological responses to a short-term, environmentally realistic, acute heat stress in Atlantic salmon, Salmo salar

FACETS, 2017
Atlantic salmon populations are declining, and warming river temperatures in the summer months are thought to be a significant contributing factor. We describe the time course of cellular and metabolic responses to an ecologically relevant short-term ...
Melanie J. Gallant, Sacha LeBlanc, Tyson J. MacCormack, Suzanne Currie   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Heat Shock-Induced Dephosphorylation of Eukaryotic Elongation Factor 1BδL by Protein Phosphatase 1

Frontiers in Molecular Biosciences, 2021
Several variant proteins are produced from EEF1D, including two representative proteins produced via alternative splicing machinery. One protein is the canonical translation eukaryotic elongation factor eEF1Bδ1, and the other is the heat shock-responsive
Taku Kaitsuka, Taku Kaitsuka, Kazuhito Tomizawa, Masayuki Matsushita   +3 more
doaj   +1 more source

Cooperative Binding of Heat Shock Factor to the Yeast \u3ci\u3eHSP82\u3c/i\u3e Promoter In Vivo and In Vitro [PDF]

, 1999
revious work has shown that heat shock factor (HSF) plays a central role in remodeling the chromatin structure of the yeastHSP82 promoter via constitutive interactions with its high-affinity binding site, heat shock element 1 (HSE1).
Erkine, Alexander M., Gross, David S., Magrogan, Serena F., Sekinger, Edward A.   +3 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source