Results 51 to 60 of about 543,466 (295)

Coactivator ASC‐2 mediates heat shock factor 1‐mediated transactivation dependent on heat shock

FEBS Letters, 2004
Upon exposure to elevated temperatures, mammalian cells increase the expression of the heat shock proteins (HSP) through activation of the heat shock factor 1 (HSF1). Since most transcription factors require coactivators for efficient transcriptional activity, we tried to identify the coactivator(s) that interacts with and modulates the activities of ...
Hong, SunHwa, Kim, Sun Hee, Heo, Mi Ae, Choi, Yoon Ha, Park, Min Jung, Yoo, Mi Ae, Kim, Han Do, Kang, Ho Sung, Cheong, JaeHun   +8 more
openaire   +2 more sources

Heterogeneous nuclear ribonucleoprotein K inhibits heat shock-induced transcriptional activity of heat shock factor 1 [PDF]

Journal of Biological Chemistry, 2017
When cells are exposed to heat shock and various other stresses, heat shock factor 1 (HSF1) is activated, and the heat shock response (HSR) is elicited. To better understand the molecular regulation of the HSR, we used 2D-PAGE-based proteome analysis to screen for heat shock-induced post-translationally modified cellular proteins. Our analysis revealed
Hee-Jung, Kim, Jae-Jin, Lee, Jin-Hwan, Cho, Jaeho, Jeong, A Young, Park, Wonmo, Kang, Kong-Joo, Lee   +6 more
openaire   +2 more sources

Hspb1 inhibits microglial ferroptosis and pro-inflammatory activation to alleviate cerebral ischemia/reperfusion injury in mice

Neural Regeneration Research
Heat shock protein beta-1 may be involved in regulating ferroptosis in cells. The expression of heat shock protein beta-1 is upregulated after stroke; however, the underlying mechanism of action of heat shock protein beta-1 in cerebral ischemia ...
Weilong Hua, Hongye Xu, Rundong Chen, Yiyong Zeng, Lei Zhang, Yongxin Zhang, Xiaoxi Zhang, Yongwei Zhang, Hongjian Zhang, Jianmin Liu, Pengfei Yang   +10 more
doaj   +1 more source

Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response

Pharmaceutical Biology, 2022
Context Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs).
Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han   +7 more
doaj   +1 more source

Heat shock factor-1 protein in heat shock factor-1 gene-transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein-70 production. [PDF]

Journal of Clinical Investigation, 1997
Heat shock factor-1 (HSF1) is a transcriptional factor that binds to heat shock elements located on the promoter region of heat shock protein genes. The purpose of this study was to further investigate the regulation of the expression of the heat shock protein-70 (HSP-70) gene.
X Z, Ding, G C, Tsokos, J G, Kiang
openaire   +2 more sources

Mechanisms of Hsp90 regulation [PDF]

, 2016
Heat shock protein 90 (Hsp90) is a molecular chaperone that is involved in the activation of disparate client proteins. This implicates Hsp90 in diverse biological processes that require a variety of co-ordinated regulatory mechanisms to control its ...
Ahn, Akira, Ali, Ali, Amin, Ammirante, Anckar, Anckar, Azevedo, Bali, Bandhakavi, Bansal, Bansal, Bansal, Barlev, Bharadwaj, Blank, Boellmann, Bonizzi, Bonner, Broemer, Brown, Bruce, Budzynski, Bulman, Catlett, Chen, Chen, Chen, Chen, Cho, Chrisostomos Prodromou, Combates, Cotto, Csermely, Cunningham, da Silva Correia, Deb, Dunn, Echeverria, Ehret, Espinosa, Farkas, Field, Finka, Frey, Geiss-Friedlander, Gerondakis, Ghosh, Gomez, Grad, Graf, Gugasyan, Gupta, Hashikawa, Hashikawa, Heimberger, Hensold, Hessling, Hickey, Hietakangas, Holmberg, Holmberg, Holt, Horejsi, Hubert, Ito, Jakob, Johnson, Jurivich, Kadota, Kekatpure, Kettenbach, Kitagawa, Kline, Knauf, Kobayashi, Kugel, Legagneux, Lei, Leskovar, Li, Li, Lindquist, Lingelbach, Liu, Liu, Longshaw, Lu, Makhnevych, Martinez-Ruiz, Mayor, McConnell, McLaughlin, Meyer, Meyer, Meyer, Mitsiades, Miyata, Miyata, Mollapour, Mollapour, Mollapour, Mollapour, Mollapour, Mollapour, Morimoto, Muller, Murphy, Murtagh, Napetschnig, Neef, Newton, Nieto-Sotelo, Oeckinghaus, Ogiso, Onuoha, Panaretou, Park, Pattaramanon, Pearl, Pearl, Pelham, Peteranderl, Picard, Pirkkala, Pittet, Pratt, Pratt, Prodromou, Prodromou, Prodromou, Prodromou, Prodromou, Qing, Quanz, Rabindran, Rebbe, Retzlaff, Retzlaff, Richter, Roe, Rutherford, Sakurai, Sbroggio, Scheufler, Schuler, Scroggins, Shamovsky, Shao, Shen, Shi, Shiau, Shirasu, Siligardi, Siligardi, Smale, Smith, Solier, Sorger, Sorger, Sorger, Southworth, Steensgaard, Stephanou, Stephanou, Taipale, Takahashi, Takai, Vaughan, Vaughan, Verghese, Voellmy, Voss, Vujanac, Wandinger, Wang, Weikl, Westerheide, Whitesell, Wiederrecht, Williams, Xiao, Xu, Xu, Yahara, Yamamoto, Yang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhong, Zhou, Zou, Zuehlke, Zuo, Zuo   +199 more
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Genomic Heat Shock Element Sequences Drive Cooperative Human Heat Shock Factor 1 DNA Binding and Selectivity [PDF]

Journal of Biological Chemistry, 2014
The heat shock transcription factor 1 (HSF1) activates expression of a variety of genes involved in cell survival, including protein chaperones, the protein degradation machinery, anti-apoptotic proteins, and transcription factors. Although HSF1 activation has been linked to amelioration of neurodegenerative disease, cancer cells exhibit a dependence ...
Jaeger, Alex M, Makley, Leah N, Gestwicki, Jason E, Thiele, Dennis J   +3 more
openaire   +4 more sources

Possible Involvement of HSP90-HSF1 Multichaperone Complex in Impairment of HSP72 Induction in the Failing Heart Following Myocardial Infarction in Rats

Journal of Pharmacological Sciences, 2013
It is generally accepted that an increase in the myocardial level of heat-shock protein 72 (HSP72) protects viable cardiac tissue against myocardial infarction (MI)-induced stress.
Tetsuro Marunouchi, Masato Araki, Mao Murata, Norio Takagi, Kouichi Tanonaka   +4 more
doaj   +1 more source

HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity

Cells, 2020
Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for responding to proteotoxic stress and involves the rapid expression of heat ...
Thomas L. Prince, Benjamin J. Lang, Martin E. Guerrero-Gimenez, Juan Manuel Fernandez-Muñoz, Andrew Ackerman, Stuart K. Calderwood   +5 more
doaj   +1 more source

Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans [PDF]

, 2018
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced ...
AN, SEON WOO, Ao-Lin Hsu, Chang Man Ha, Eun-Seok Choi, Eunju Kim, Haeshim Baek, Heehwa G. Son, JANG, SUNG KEY, Keunhee Seo, LEE, SEUNG JAE, LEE, YUJIN, Mihwa Seo, ROH, TAE YOUNG, SANGSOON, PARK, Seokjin Ham, Youngjae Ryu   +15 more
core   +1 more source