Results 51 to 60 of about 198,478 (151)

Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast. [PDF]

PLoS ONE, 2011
Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that include protein
Liliana Batista-Nascimento, Daniel W Neef, Phillip C C Liu, Claudina Rodrigues-Pousada, Dennis J Thiele   +4 more
doaj   +1 more source

PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element

Cells, 2022
At present, the barrier to HIV-1 functional cure is the persistence of HIV-1 reservoirs. The “shock (reversing latency) and kill (antiretroviral therapy)” strategy sheds light on reducing or eliminating the latent reservoir of HIV-1. However, the current
Xinfeng Xu, Yingtong Lin, Xiaoyun Zeng, Chan Yang, Siqin Duan, Liqiong Ding, Wanzhen Lu, Jian Lin, Xiaoyan Pan, Xiancai Ma, Shuwen Liu   +10 more
doaj   +1 more source

Heat Shock Factor 1 Mediates Latent HIV Reactivation [PDF]

Scientific Reports, 2016
AbstractHSF1, a conserved heat shock factor, has emerged as a key regulator of mammalian transcription in response to cellular metabolic status and stress. To our knowledge, it is not known whether HSF1 regulates viral transcription, particularly HIV-1 and its latent form.
Xiao-Yan Pan, Wei Zhao, Xiao-Yun Zeng, Jian Lin, Min-Min Li, Xin-Tian Shen, Shu-Wen Liu   +6 more
openaire   +2 more sources

Heat-inducible DNA Binding of Purified Heat Shock Transcription Factor 1 [PDF]

Journal of Biological Chemistry, 1995
The heat-induced expression of heat shock proteins, called the cellular stress response, is mediated by heat shock transcription factor 1 (HSF1). HSF1 exists in unstressed cells in an inactive form, which is converted to the DNA binding from upon exposure of cells to elevated temperature.
M L, Goodson, K D, Sarge
openaire   +2 more sources

Physiological responses to a short-term, environmentally realistic, acute heat stress in Atlantic salmon, Salmo salar

FACETS, 2017
Atlantic salmon populations are declining, and warming river temperatures in the summer months are thought to be a significant contributing factor. We describe the time course of cellular and metabolic responses to an ecologically relevant short-term ...
Melanie J. Gallant, Sacha LeBlanc, Tyson J. MacCormack, Suzanne Currie   +3 more
doaj   +1 more source

Xenopus Heat Shock Factor 1 Is a Nuclear Protein before Heat Stress [PDF]

Journal of Biological Chemistry, 1997
Stress-induced expression of the heat shock (hs) genes in eukaryotes is mediated by a transcription factor known as heat shock factor 1 (HSF1). HSF1 is present in a latent, monomeric form in unstressed metazoan cells and upon exposure to heat or other forms of stress is converted to an "active" trimeric form, which binds the promoters of hs genes and ...
P A, Mercier, J, Foksa, N, Ovsenek, J T, Westwood   +3 more
openaire   +2 more sources

A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions. [PDF]

PLoS ONE, 2009
BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown.
Umashankar Singh, Erik Bongcam-Rudloff, Bengt Westermark   +2 more
doaj   +1 more source

The CBP-1/p300 Lysine Acetyltransferase Regulates the Heat Shock Response in C. elegans

Frontiers in Aging, 2022
The decline of proteostasis is a hallmark of aging that is, in part, affected by the dysregulation of the heat shock response (HSR), a highly conserved cellular response to proteotoxic stress in the cell. The heat shock transcription factor HSF-1 is well-
Lindsey N. Barrett, Sandy D. Westerheide
doaj   +1 more source

Heat Shock-Induced Dephosphorylation of Eukaryotic Elongation Factor 1BδL by Protein Phosphatase 1

Frontiers in Molecular Biosciences, 2021
Several variant proteins are produced from EEF1D, including two representative proteins produced via alternative splicing machinery. One protein is the canonical translation eukaryotic elongation factor eEF1Bδ1, and the other is the heat shock-responsive
Taku Kaitsuka, Taku Kaitsuka, Kazuhito Tomizawa, Masayuki Matsushita   +3 more
doaj   +1 more source

Coactivator ASC‐2 mediates heat shock factor 1‐mediated transactivation dependent on heat shock

FEBS Letters, 2004
Upon exposure to elevated temperatures, mammalian cells increase the expression of the heat shock proteins (HSP) through activation of the heat shock factor 1 (HSF1). Since most transcription factors require coactivators for efficient transcriptional activity, we tried to identify the coactivator(s) that interacts with and modulates the activities of ...
Hong, SunHwa, Kim, Sun Hee, Heo, Mi Ae, Choi, Yoon Ha, Park, Min Jung, Yoo, Mi Ae, Kim, Han Do, Kang, Ho Sung, Cheong, JaeHun   +8 more
openaire   +2 more sources