Results 31 to 40 of about 198,478 (151)

Inhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A

Cells, 2021
Manumycin A (MA) is a well-tolerated natural antibiotic showing pleiotropic anticancer effects in various preclinical in vitro and in vivo models.
Damian Robert Sojka, Sylwia Hasterok, Natalia Vydra, Agnieszka Toma-Jonik, Anna Wieczorek, Agnieszka Gogler-Pigłowska, Dorota Scieglinska   +6 more
doaj   +1 more source

Transient intracellular acidification regulates the core transcriptional heat shock response

eLife, 2020
Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought ...
Catherine G Triandafillou, Christopher D Katanski, Aaron R Dinner, D Allan Drummond   +3 more
doaj   +1 more source

Unraveling complex interplay between heat shock factor 1 and 2 splicing isoforms. [PDF]

PLoS ONE, 2013
Chaperone synthesis in response to proteotoxic stress is dependent on a family of transcription factors named heat shock factors (HSFs). The two main factors in this family, HSF1 and HSF2, are co-expressed in numerous tissues where they can interact and ...
Sylvain Lecomte, Léa Reverdy, Catherine Le Quément, Florent Le Masson, Axelle Amon, Pascale Le Goff, Denis Michel, Elisabeth Christians, Yves Le Dréan   +8 more
doaj   +1 more source

Manipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression. [PDF]

PLoS ONE, 2010
BACKGROUND: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in the Xenopus tadpole.
Ron P Dirks, Remon van Geel, Sanne M M Hensen, Siebe T van Genesen, Nicolette H Lubsen   +4 more
doaj   +1 more source

Tracking the Activation of Heat Shock Signaling in Cellular Protection and Damage

Cells, 2022
Heat Shock (HS) signaling is activated in response to various types of cellular stress. This activation serves to protect cells from immediate threats in the surrounding environment.
Shisui Torii, Pasko Rakic
doaj   +1 more source

Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages

Journal of Inflammation, 2005
Background Viruses remain one of the inducers of the stress response in the infected cells. Heat shock response induced by vaccinia virus (VV) infection was studied in vitro in human blood monocyte derived macrophages (MDMs) as blood cells usually ...
Dziedzic Jakub, Slezak Kinga, Guzik Krzysztof, Kowalczyk Aleksandra, Rokita Hanna   +4 more
doaj   +1 more source

Activation of heat-shock transcription factor 1 by hypertonic shock in 3T3 cells [PDF]

Biochemical Journal, 1996
The exposure of 3T3 cells to a medium made hypertonic by the addition of NaCl induced activation of a heat-shock transcription factor (HSF). This activation, as monitored by gel-mobility-shift assays, occurred within 10 min of hypertonic shock and was dose-dependent in relation to the osmotic strength of the medium up to 0.7 osM.
ALFIERI, Roberta, PETRONINI, Pier Giorgio, BORGHETTI, Angelo, URBANI S.   +3 more
openaire   +2 more sources

Host proteostasis modulates influenza evolution

eLife, 2017
Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens.
Angela M Phillips, Luna O Gonzalez, Emmanuel E Nekongo, Anna I Ponomarenko, Sean M McHugh, Vincent L Butty, Stuart S Levine, Yu-Shan Lin, Leonid A Mirny, Matthew D Shoulders   +9 more
doaj   +1 more source

Induction of the Heat Shock Pathway during Hypoxia Requires Regulation of Heat Shock Factor by Hypoxia-inducible Factor-1 [PDF]

Journal of Biological Chemistry, 2006
Activation of heat shock proteins (Hsps) is critical to adaptation to low oxygen levels (hypoxia) and for enduring the oxidative stress of reoxygenation. Hsps are known to be regulated by heat shock factor (Hsf), but our results demonstrate an unexpected regulatory link between the oxygen-sensing and heat shock pathways.
Nathan A, Baird, Douglas W, Turnbull, Eric A, Johnson   +2 more
openaire   +2 more sources

Hspb1 inhibits microglial ferroptosis and pro-inflammatory activation to alleviate cerebral ischemia/reperfusion injury in mice

Neural Regeneration Research
Heat shock protein beta-1 may be involved in regulating ferroptosis in cells. The expression of heat shock protein beta-1 is upregulated after stroke; however, the underlying mechanism of action of heat shock protein beta-1 in cerebral ischemia ...
Weilong Hua, Hongye Xu, Rundong Chen, Yiyong Zeng, Lei Zhang, Yongxin Zhang, Xiaoxi Zhang, Yongwei Zhang, Hongjian Zhang, Jianmin Liu, Pengfei Yang   +10 more
doaj   +1 more source