Cells, 2021 Manumycin A (MA) is a well-tolerated natural antibiotic showing pleiotropic anticancer effects in various preclinical in vitro and in vivo models.
Damian Robert Sojka +6 more
doaj +1 more source
Heat-inducible DNA Binding of Purified Heat Shock Transcription Factor 1 [PDF]
Journal of Biological Chemistry, 1995 The heat-induced expression of heat shock proteins, called the cellular stress response, is mediated by heat shock transcription factor 1 (HSF1). HSF1 exists in unstressed cells in an inactive form, which is converted to the DNA binding from upon exposure of cells to elevated temperature.
M L, Goodson, K D, Sarge
openaire +2 more sources
Unraveling complex interplay between heat shock factor 1 and 2 splicing isoforms. [PDF]
PLoS ONE, 2013 Chaperone synthesis in response to proteotoxic stress is dependent on a family of transcription factors named heat shock factors (HSFs). The two main factors in this family, HSF1 and HSF2, are co-expressed in numerous tissues where they can interact and ...
Sylvain Lecomte +8 more
doaj +1 more source
Hopf bifurcation in a gene regulatory network model: Molecular movement causes oscillations [PDF]
, 2015 Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes.
Chaplain, M, Ptashnyk, M, Sturrock, M
core +1 more source
Transient intracellular acidification regulates the core transcriptional heat shock response
eLife, 2020 Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought ...
Catherine G Triandafillou +3 more
doaj +1 more source
Manipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression. [PDF]
PLoS ONE, 2010 BACKGROUND: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in the Xenopus tadpole.
Ron P Dirks +4 more
doaj +1 more source
Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation [PDF]
, 2013 Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-kappa B-mediated gene expression.
Bahar, Ali A +18 more
core +4 more sources
Activation of Heat Shock Transcription Factor 1 in Atherosclerosis [PDF]
The American Journal of Pathology, 2003 Previous work established that increased expression of heat shock proteins (HSPs) in the vessel wall might evoke proinflammatory and autoimmune reactions in the pathogenesis of atherosclerosis. The present study was designed to further scrutinize the molecular mechanisms of HSP expression involving activation of heat shock transcription factors (HSFs ...
Bernhard, Metzler +6 more
openaire +2 more sources
Journal of Inflammation, 2005 Background Viruses remain one of the inducers of the stress response in the infected cells. Heat shock response induced by vaccinia virus (VV) infection was studied in vitro in human blood monocyte derived macrophages (MDMs) as blood cells usually ...
Dziedzic Jakub +4 more
doaj +1 more source
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis [PDF]
, 2018 Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated with massive protein ...
Airoldi, Edoardo M. +7 more
core +1 more source