Results 81 to 90 of about 13,686 (217)

HSF1 inhibition attenuates cancer cell survival. [PDF]

, 2014
(A) iaRNAHSF1 expression does not affect normal cells (IMR90), yet induces an abnormal morphology in HeLa cervical carcinoma and chemically transformed kidney cells (293T). (B).
Richard A. Cerione (464912), John T. Lis (7283), H. Hans Salamanca (560402), Marc A. Antonyak (560403), Hua Shi (7282)   +4 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

The potential of ethanolic extract of Moringa oleifera leaves on HSF1 expression in oral cancer induced by benzo[a]pyrene

Dental Journal, 2020
Background: Oral cancer is the sixth most common malignancy that occurs in the world, with more than 330,000 deaths a year. In cancer, mutations occur in proteins, accompanied by unfolding proteins, caused by the unstable micro-environment in cells.
Vania Syahputri, Theresia Indah Budhy, Bambang Sumaryono   +2 more
doaj   +1 more source

S303 phosphorylation of HSF1 in yeast is modulated by Slt2. [PDF]

, 2013
(A) PS145 and LNY2 (slt2Δ) were transformed with a plasmid expressing wild-type HSF1 and were grown on galactose containing medium. Total protein extracts were analyzed for pS303, total HSF1 and Pgk1 by immunoblotting. (B) PS145 (WT) expressing wild-type
Claudina Rodrigues-Pousada (164208), Dennis J. Thiele (227319), Daniel W. Neef (254588), Phillip C. C. Liu (357929), Liliana Batista-Nascimento (357926)   +4 more
core   +1 more source

Chronic thermal stress affects growth, liver morphology and molecular responses but allows recovery at optimal temperature in juvenile zebrafish (Danio rerio)

Journal of Fish Biology, EarlyView.
Abstract Climate‐driven aquatic heatwaves pose an increasing threat to fish populations by inducing prolonged thermal stress. However, the resilience of teleosts to chronic heat exposure and their capacity for recovery remains poorly understood. This study investigated the effects of chronic high‐temperature exposure on juvenile zebrafish (Danio rerio).
Monique Adzijovski, Aaron G. Schultz, Jemma Bergfeld, Luis O. B. Afonso   +3 more
wiley   +1 more source

Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons

Journal of Anatomy, EarlyView.
To study gene expression in subpopulations of cortical subplate neurons (Lpar1‐EGFP‐positive and D1B‐positive SpN clusters), we applied gene expression profiling, including bulk microarray analysis, single‐cell RNA sequencing (scRNA‐seq), and Visium spatial transcriptomics, and identified both overlapping and unique gene expression signatures ...
Hitomi Achiwa, Yuichiro Hara, Hideya Kawaji, Minori Oshima, Noe Kaneko, Ayumu Morioka, Anna Hoerder‐Suabedissen, Zoltán Molnár, Chiaki Ohtaka‐Maruyama   +8 more
wiley   +1 more source

HSF1 functions as a transcription regulator for Dp71 expression [PDF]

Cell Stress and Chaperones, 2015
Heat shock factor 1 (HSF1) is one of the most important transcriptional molecules in the heat shock process; however, HSF1 can also regulate the expression of other proteins. Dystrophin Dp71 is one of the most widely expressed isoforms of the dystrophin gene family.
Jin, Tan, Sichuang, Tan, Hexin, Zheng, Meidong, Liu, Guangwen, Chen, Huali, Zhang, Kangkai, Wang, Sipin, Tan, Jiang, Zhou, Xian-zhong, Xiao   +9 more
openaire   +2 more sources

Stress tolerance in diapausing embryos of Artemia franciscana is dependent on heat shock factor 1 (Hsf1).

PLoS ONE, 2018
Embryos of the crustacean, Artemia franciscana, may undergo oviparous development, forming encysted embryos (cysts) that are released from females and enter diapause, a state of suppressed metabolism and greatly enhanced stress tolerance.
Jiabo Tan, Thomas H MacRae
doaj   +1 more source

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space. [PDF]

PLoS Genetics, 2018
The capacity to respond to temperature fluctuations is critical for microorganisms to survive within mammalian hosts, and temperature modulates virulence traits of diverse pathogens.
Amanda O Veri, Zhengqiang Miao, Rebecca S Shapiro, Faiza Tebbji, Teresa R O'Meara, Sang Hu Kim, Juan Colazo, Kaeling Tan, Valmik K Vyas, Malcolm Whiteway, Nicole Robbins, Koon Ho Wong, Leah E Cowen   +12 more
doaj   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source