Results 81 to 90 of about 13,678 (223)

Stress tolerance in diapausing embryos of Artemia franciscana is dependent on heat shock factor 1 (Hsf1).

PLoS ONE, 2018
Embryos of the crustacean, Artemia franciscana, may undergo oviparous development, forming encysted embryos (cysts) that are released from females and enter diapause, a state of suppressed metabolism and greatly enhanced stress tolerance.
Jiabo Tan, Thomas H MacRae
doaj   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space. [PDF]

PLoS Genetics, 2018
The capacity to respond to temperature fluctuations is critical for microorganisms to survive within mammalian hosts, and temperature modulates virulence traits of diverse pathogens.
Amanda O Veri, Zhengqiang Miao, Rebecca S Shapiro, Faiza Tebbji, Teresa R O'Meara, Sang Hu Kim, Juan Colazo, Kaeling Tan, Valmik K Vyas, Malcolm Whiteway, Nicole Robbins, Koon Ho Wong, Leah E Cowen   +12 more
doaj   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

Intracellular localization of HSF1 transcription factor in HeLa cells.

, 2013
CLSM images of wild type HSF1-eGFP, HSF1-ΔTRIM-eGFP, HSF1-K80Q-eGFP and HSF1-ΔDBD-eGFP before (NHS) and after a one hour heat shock (HS). HSF1 is predominantly nuclear except when the trimerization domain is deleted.
Antoine Delon (431449), Claire Vourc’h (431448), Gaëtan Herbomel (431444), Yves Usson (431447), Eric G. Folco (310374), Catherine Souchier (431450), Meike Kloster-Landsberg (431445), Edwige Col (431446)   +7 more
core   +1 more source

Mass spectrometry proteomics for studying mitostasis

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Maintaining mitochondrial integrity and function is fundamental to cellular homeostasis. Cells rely on coordinated protein quality control (QC) systems—including intricate chaperone‐protease networks, the ubiquitin‐proteasome system, and cytosolic surveillance pathways—that together form a dynamic, cell‐wide mitostasis network governing the ...
Lakshita Sharma, Sristi Chakroborty, Hirak Das, Silke Oeljeklaus, Julian Bender, Bettina Warscheid   +5 more
wiley   +1 more source

The SmHsf1 antibody recognizes the SmHsf1 protein.

, 2014
Purified IgG from SmHsf1-immunized rabbit bleeds (lanes 1–4) or pre-immune serum (lane 5) were used in a Western blot to test for reactivity against bacterially expressed recombinant proteins and cercarial extract (lane 1), 1 µg MBP negative control ...
Giselle M. Knudsen (217467), Melissa Varrecchia (568264), Kenji Ishida (568265), Emmitt R. Jolly (189615)   +3 more
core   +1 more source

Unveiling Candidate Markers for Drug Resistance or Synthetic Lethality in Cervical Cancer: Integrative Analysis of Genetic and Pharmacoprofiling

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Systemic cervical cancer management continues to be challenging. Numerous chemotherapies have been approved, but predicting response is difficult due to the lack of biomarkers. Here, we analyze the genetic and protein profiles of 20 cervical cancer cell lines (CCCLs) and explore their correlation with drug response patterns to ...
Suzy Scholl, Elaine Del Nery, Pierre Gestraud, Maral Halladjian, Elodie Girard, Adèle Soria, Elodie Anthony, Leanne De Koning, Nicolas Servant, Els Berns, Maud Kamal   +10 more
wiley   +1 more source

Single‐cell profiling reveals peripheral blood immune landscape remodelling in breast cancer lymph node metastasis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
scRNA‐seq reveals pro‐metastatic neutrophil and exhausted T/NK subsets in BC patients with LN metastasis. Interferon‐stimulated neutrophils secrete LGALS9, drives T/NK cell exhaustion via HAVCR2. Neutralising LGALS9 restores T‐cell anti‐tumour activity, suggesting a novel therapeutic target.
Bo Chen, Kang Ma, Yunjie Wang, Liulu Zhang, Xinyue Feng, Cheng Long, Xuejing Tan, Kun Wang   +7 more
wiley   +1 more source

DNA binding of HSF1 to HSE after heat shock.

, 2013
Endogenous and full-length HSF1, but not HSF1 mutants, only bind to HSE. The biotinylated double-stranded oligonucleotides harboring the HSE motif were incubated with cellular extracts obtained from cell lines expressing the full length HSF1-eGFP (wt ...
Antoine Delon (431449), Claire Vourc’h (431448), Gaëtan Herbomel (431444), Yves Usson (431447), Eric G. Folco (310374), Catherine Souchier (431450), Meike Kloster-Landsberg (431445), Edwige Col (431446)   +7 more
core   +1 more source