Results 91 to 100 of about 13,678 (223)
Effects of LRP1B Regulated by HSF1 on Lipid Metabolism in Hepatocellular Carcinoma
Journal of Hepatocellular Carcinoma, 2020 Miaomiao Li,1,* Juntao Hu,2,* Riming Jin,3,* Hongxia Cheng,1 Huaping Chen,4 Limin Li,4 Kun Guo1 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People ...
Li M +6 more
doaj
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Perfluoroheptanoic acid (PFHpA) induces premature senescence in normal human skin fibroblasts (HSFs), as characterized by decreased cell viability, increased SA‐β‐gal staining, impaired wound healing, cell cycle dysregulation, elevated ROS levels, and upregulated SASP mRNA expression.
Jiaqi Fu +7 more
wiley +1 more source
HSF1 mediated stress response of heavy metals
PLOS ONE, 2018 The heat shock response (HSR) pathway is a highly conserved cellular stress response and mediated by its master regulator HSF1. Activation of the pathway results in the expression of chaperone proteins (heat shock proteins; HSP) to maintain protein homeostasis. One of the genes strongest upregulated upon stress is HSPA1A (HSP72).
Christoph Steurer +8 more
openaire +3 more sources
Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
Advanced Genetics, Volume 7, Issue 2, June 2026.This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley +1 more source
Roles of histone lysine methylation in neurodevelopment and related disorders
Ibrain, Volume 12, Issue 2, Page 201-221, Summer 2026.This graphical abstract centers on the theme of dynamic balance and systematically outlines the role of histone lysine methylation in neurodevelopment and related disorders. The figure first presents two key classes of regulators that control this balance—“writers” and “erasers”—and then indicates how interactions among different epigenetic ...
Yun Chen +3 more
wiley +1 more source
, 2017 Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program.
Megan L. Tigue +12 more
core +1 more source
Med Research, Volume 2, Issue 2, Page 280-308, June 2026.White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang +12 more
wiley +1 more source
A schematic presentations of the various Hsf1 activation pathways.
, 2014 The three stresses, heat shock, oxidative stress and sugar starvation, activate the inactive Hsf1 through different mediators, Sir2, Yap1 and Snf1, respectively.
Esther Weindling (651935) +4 more
core +1 more source
Role of HSF1 expression for tumor microenvironment in intrahepatic cholangiocarcinoma.
, 2017 249 Background: Heat shock factor 1 (HSF1) is a master regulator of heat shock response. HSF1 is recently identified to play a multifaceted role in cancer progression.
Mitsuo Shimada +7 more
core +1 more source
Aging Cell, Volume 25, Issue 6, June 2026.Aged mouse skeletal muscle exhibits greater mtUPR transcriptional initiation following repeated physical stress than young mice, coinciding with reduced mitochondrial proteostatic reserve and heightened oxidative burden. We implicate a mtROS‐JNK‐CHOP axis as a contributor to the enhanced response.
Grant R. Laskin +2 more
wiley +1 more source