Results 111 to 120 of about 13,686 (217)

Upregulation of HSF1 in estrogen receptor positive breast cancer [PDF]

, 2016
Heat shock transcription factor 1 (HSF1), a key regulator of the heat-shock response, is deregulated in many cancers. HSF1 can mediate cancer cell survival and metastasis. High levels of HSF1 have been associated with poor prognosis in breast cancer. The
Badve, Sunil S., Gökmen-Polar, Yesim
core   +3 more sources

Direct activation of HSF1 by macromolecular crowding and misfolded proteins.

PLoS ONE
Stress responses play a vital role in cellular survival against environmental challenges, often exploited by cancer cells to proliferate, counteract genomic instability, and resist therapeutic stress.
Oliver Simoncik, Vlastimil Tichy, Michal Durech, Lenka Hernychova, Filip Trcka, Lukas Uhrik, Miroslav Bardelcik, Philip J Coates, Borivoj Vojtesek, Petr Muller   +9 more
doaj   +1 more source

Interactions between extracellular Hsp72 and blood cells [PDF]

, 2010
Not to be added to EThOSIn recent years, compelling evidence has accumulated suggesting heat shock proteins (HSPs) which are generally believed to be localised and functioning mainly within eukaryotic cells as cyto-protective molecular chaperones, are ...
Williams, Helen
core  

KPT-185 diminishes HSP70, HSF1 and p-HSF1^Ser326 expression. [PDF]

, 2015
After an 18-h treatment of KPT-185 (i.e., 50 nM for Z138, 100 nM for JVM2, MINO, and Jeko-1), the cells were lysed and analyzed HSP70 (A) and HSF1 and p-HSF1Ser326 expression (B) by immunoblot as described in Fig 2.
Richard Eric Davis (792122), Michael Andreeff (31491), Hiromichi Matsushita (405560), Kazumasa Sekihara (485106), Michael Kauffman (519875), Jo Ishizawa (792124), Takashi Miida (427420), Saiko Kazuno (495066), Sharon Shacham (519876), Zhiqiang Wang (48987), Yoko Tabe (427415), Shinichi Yamamoto (792121), Takashi Ueno (411589), Tsutomu Fujimura (495062), Kensuke Kojima (517560), Wencai Ma (792123)   +15 more
core   +1 more source

Potential targets for HSF1 within the preinitiation complex

Cell Stress & Chaperones, 2000
Protein-protein interactions between human heat shock transcription factor 1 (hHSF1) and general transcription factors TFIIA-gamma, TFIIB, TBP, TAF(II)32, and TAF(II)55 and positive coactivator PC4 were characterized in order to identify potential targets of contact in the transcriptional preinitiation complex. These contacts represent one of the final
C X, Yuan, W B, Gurley
openaire   +3 more sources

Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN

Cancer Medicine
Background Heat shock transcription factors (HSFs) play crucial roles in the development of malignancies. However, the specific roles of HSFs in hepatocellular carcinoma (HCC) have yet to be fully elucidated.Aims:To explore the involvement of the HSF ...
Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He   +4 more
doaj   +1 more source

Protein Misfolding Releases Human HSF1 from HSP70 Latency Control [PDF]

Heat shock factor 1 (HSF1) responds to stress to mount the heat shock response (HSR), a conserved transcriptional program that allows cells to maintain proteostasis by upregulating heat shock proteins (HSPs).
Ciccarelli, Michela,, Andréasson, Claes,   +1 more
core   +1 more source

Heat shock factor 1 promotes proliferation and chemoresistance in diffuse large B-cell lymphoma by enhancing the cell cycle and DNA repair

Cell Death and Disease
Diffuse large B-cell lymphoma (DLBCL) is commonly treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), but up to 40% of patients have refractory or relapsing disease and show unsatisfactory responses to salvage ...
Yu Fang, Liang Cheng, Ming Huang, Yi Cao, Qihua Zou, Jun Cai, Yuchen Zhang, Yi Xia, Huiqiang Huang, Xu Chen, Qingqing Cai   +10 more
doaj   +1 more source

HSP90 Family Members, Their Regulators and Ischemic Stroke Risk: A Comprehensive Molecular-Genetics and Bioinformatics Analysis

Frontiers in Bioscience-Scholar
Background: Disruptions in proteostasis are recognized as key drivers in cerebro- and cardiovascular disease progression. Heat shock proteins (HSPs), essential for maintaining protein stability and cellular homeostasis, are pivotal in ...
Ksenia Kobzeva, Maxim Ivenkov, Rostislav Gromov, Olga Bushueva   +3 more
doaj   +1 more source

Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression

Neoplasia: An International Journal for Oncology Research
Background: Glioblastoma (GBM) poses a significant medical challenge due to its aggressive nature and poor prognosis. Mitochondrial unfolded protein response (UPRmt) and the heat shock factor 1 (HSF1) pathway play crucial roles in GBM pathogenesis.
Xiang Li, Zongqi Wang, Bixi Gao, Kun Dai, Jiang Wu, Kecheng Shen, Guangzhao Li, Xiaowang Niu, Xin Wu, Longyuan Li, Haitao Shen, Haiying Li, Zhengquan Yu, Zhong Wang, Gang Chen   +14 more
doaj   +1 more source