Results 111 to 120 of about 13,678 (223)

Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda, Renu Khasa, Srinivasan Chinnapaiyan, Saurabh Aggarwal, Irfan Rahman, Hoshang Unwalla   +5 more
wiley   +1 more source

HSF1 transcriptional activity is modulated by IER5 and PP2A/B55

, 2015
Heat shock factor 1 (HSF1) is the master transcriptional regulator of chaperone genes. HSF1 regulates the expression of the immediate-early response gene IER5, which encodes a protein that has roles in the stress response and cell proliferation. Here, we
Kawabata, Shotaro, Ishikawa, Yukio, Sakurai, Hiroshi   +2 more
core   +1 more source

RNAi based transcriptome suggests genes potentially regulated by HSF1 in the Pacific oyster Crassostrea gigas under thermal stress

BMC Genomics, 2019
Background The Pacific oyster Crassostrea gigas is an important fishery resource that is sensitive to temperature fluctuations. Thus, it has evolved a protection mechanism against heat stress by increasing the expression of the gene coding for heat shock
Youli Liu, Li Li, Baoyu Huang, Wei Wang, Guofan Zhang   +4 more
doaj   +1 more source

GSK3 represses HSF1 activity in yeast independent of S303.

, 2013
(A) PS145 (WT) expressing wild-type HSF1 or the S303A HSF1 mutant and LNY1 (rim11Δ) expressing wild-type HSF1 were grown in dextrose supplemented medium for 4 d. Growth was monitored by measuring O.D.600.
Claudina Rodrigues-Pousada (164208), Dennis J. Thiele (227319), Daniel W. Neef (254588), Phillip C. C. Liu (357929), Liliana Batista-Nascimento (357926)   +4 more
core   +1 more source

Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN

Cancer Medicine
Background Heat shock transcription factors (HSFs) play crucial roles in the development of malignancies. However, the specific roles of HSFs in hepatocellular carcinoma (HCC) have yet to be fully elucidated.Aims:To explore the involvement of the HSF ...
Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He   +4 more
doaj   +1 more source

Regulation of Hsf1 by stress response crosstalk in Saccharomyces cerevisiae

, 2021
Heat shock factor 1 (Hsf1) is a conserved transcription factor involved in cellular response to folding stress. A simple model has been proposed in which Hsf1 monitors misfolded protein species through a negative feedback loop.
Kane, Andrew
core  

HSP90 Family Members, Their Regulators and Ischemic Stroke Risk: A Comprehensive Molecular-Genetics and Bioinformatics Analysis

Frontiers in Bioscience-Scholar
Background: Disruptions in proteostasis are recognized as key drivers in cerebro- and cardiovascular disease progression. Heat shock proteins (HSPs), essential for maintaining protein stability and cellular homeostasis, are pivotal in ...
Ksenia Kobzeva, Maxim Ivenkov, Rostislav Gromov, Olga Bushueva   +3 more
doaj   +1 more source

Regulation of HSF1 serine 326 phosphorylation during stress.

, 2013
(A) Levels of HSF1-phosphoserine 326, total HSF1 and β-actin in HeLa cells treated with heat at 43°C for 30 min and recovered at 37°C for up to 24hr. (B) Levels of HSF1-phosphoserine 326, HSF1-phosphoserine 303, HSF1-phosphoserine 320, total HSF1, mTOR ...
Shiuh-Dih Chou (237909), Stuart K. Calderwood (191496), Jianlin Gong (317368), Thomas Prince (191492)   +3 more
core   +1 more source

HSF1 down-regulates XAF1 through transcriptional regulation

, 2006
Studies have indicated the role of HSF1 (heat-shock transcription factor 1) in repressing the transcription of some nonheat shock genes. XAF1 (XIAP-associated factor 1) was an inhibitor of apoptosis-interacting protein with the effect of antagonizing the
Yu, L, Gu, Q, An, X, Wang, J, He, H, Xia, HHX, Li, M, Kung, HF, Wong, BCY, Zou, B, Lin, MCM, Jiang, B   +11 more
core   +1 more source

Heat shock factor 1 promotes proliferation and chemoresistance in diffuse large B-cell lymphoma by enhancing the cell cycle and DNA repair

Cell Death and Disease
Diffuse large B-cell lymphoma (DLBCL) is commonly treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), but up to 40% of patients have refractory or relapsing disease and show unsatisfactory responses to salvage ...
Yu Fang, Liang Cheng, Ming Huang, Yi Cao, Qihua Zou, Jun Cai, Yuchen Zhang, Yi Xia, Huiqiang Huang, Xu Chen, Qingqing Cai   +10 more
doaj   +1 more source