Results 121 to 130 of about 13,678 (223)

RhoA activation inhibits HSF1 transcriptional activity by suppressing HSF1 binding to HSE, which is independent of HSF1 translocation and post-translational modifications.

, 2015
(A) Nuclear accumulation of HSF1 in response to HS with and without RhoA modulation by calpeptin [Calp] in cardiomyocytes. (B) HSF1 and RhoA levels in TX-100 soluble cytosolic fractions and nuclear-containing fractions of cells with and without HS and ...
Denise M. S. van Marion (772828), Femke Hoogstra-Berends (217817), Deli Zhang (240106), Robert H. Henning (108507), Harm H. Kampinga (82770), Thomas Wieland (413227), Martina Schmidt (183309), Marit Wiersma (772827), Anne-Jan Dijkhuis (772829), Roelien A. M. Meijering (217816), Bianca J. J. M. Brundel (217820)   +10 more
core   +1 more source

Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model

Scientific Reports
Female breast cancer is the most diagnosed cancer worldwide. Triple negative breast cancer (TNBC) is the most aggressive type and there is no existing endocrine or targeted therapy.
Pedro H. L. Viana, Csaba A. Schvarcz, Lea O. Danics, Balázs Besztercei, Kenan Aloss, Syeda M. Z. Bokhari, Nino Giunashvili, Dániel Bócsi, Zoltán Koós, Zoltán Benyó, Péter Hamar   +10 more
doaj   +1 more source

Overexpression or depletion of HSF1 induces filamentation.

, 2018
a) HSF1 levels can be overexpressed to different levels by placing one or both alleles of HSF1 under the control of the tetracycline-repressible promoter, tetO. Strains were grown in the absence of doxycycline (DOX) to mid-log phase.
Malcolm Whiteway (30367), Nicole Robbins (206417), Amanda O. Veri (3163503), Sang Hu Kim (828778), Rebecca S. Shapiro (137939), Zhengqiang Miao (538787), Teresa R. O’Meara (720286), Faiza Tebbji (141832), Juan Colazo (4234498), Koon Ho Wong (5028644), Leah E. Cowen (108693), Valmik K. Vyas (427501), Kaeling Tan (192448)   +12 more
core   +1 more source

Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression

Neoplasia: An International Journal for Oncology Research
Background: Glioblastoma (GBM) poses a significant medical challenge due to its aggressive nature and poor prognosis. Mitochondrial unfolded protein response (UPRmt) and the heat shock factor 1 (HSF1) pathway play crucial roles in GBM pathogenesis.
Xiang Li, Zongqi Wang, Bixi Gao, Kun Dai, Jiang Wu, Kecheng Shen, Guangzhao Li, Xiaowang Niu, Xin Wu, Longyuan Li, Haitao Shen, Haiying Li, Zhengquan Yu, Zhong Wang, Gang Chen   +14 more
doaj   +1 more source

Upregulation of HSF1 in estrogen receptor positive breast cancer

, 2016
Heat shock transcription factor 1 (HSF1), a key regulator of the heat-shock response, is deregulated in many cancers. HSF1 can mediate cancer cell survival and metastasis. High levels of HSF1 have been associated with poor prognosis in breast cancer. The
Badve, Sunil S., Gökmen-Polar, Yesim
core   +1 more source

KPT-185 diminishes HSP70, HSF1 and p-HSF1^Ser326 expression.

, 2015
After an 18-h treatment of KPT-185 (i.e., 50 nM for Z138, 100 nM for JVM2, MINO, and Jeko-1), the cells were lysed and analyzed HSP70 (A) and HSF1 and p-HSF1Ser326 expression (B) by immunoblot as described in Fig 2.
Richard Eric Davis (792122), Michael Andreeff (31491), Hiromichi Matsushita (405560), Kazumasa Sekihara (485106), Michael Kauffman (519875), Jo Ishizawa (792124), Takashi Miida (427420), Saiko Kazuno (495066), Sharon Shacham (519876), Zhiqiang Wang (48987), Yoko Tabe (427415), Shinichi Yamamoto (792121), Takashi Ueno (411589), Tsutomu Fujimura (495062), Kensuke Kojima (517560), Wencai Ma (792123)   +15 more
core   +1 more source

Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival

Communications Biology
There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target.
J. Spencer Hauck, David Moon, Xue Jiang, Mu-En Wang, Yue Zhao, Lingfan Xu, Holly Quang, William Butler, Ming Chen, Everardo Macias, Xia Gao, Yiping He, Jiaoti Huang   +12 more
doaj   +1 more source

HSF1 Gene [PDF]

, 2020
openaire   +1 more source

Role of HSF1 in cell division, tumorigenesis and therapy: a literature review

Cell Division
Heat shock factor 1 (HSF1) is the master orchestrator of the heat shock response (HSR), a critical process for maintaining cellular health and protein homeostasis.
Otakar Fiser, Petr Muller
doaj   +1 more source

Protein Misfolding Releases Human HSF1 from HSP70 Latency Control

Heat shock factor 1 (HSF1) responds to stress to mount the heat shock response (HSR), a conserved transcriptional program that allows cells to maintain proteostasis by upregulating heat shock proteins (HSPs).
Ciccarelli, Michela,, Andréasson, Claes,   +1 more
core   +1 more source