Results 121 to 130 of about 13,686 (217)

Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model

Scientific Reports
Female breast cancer is the most diagnosed cancer worldwide. Triple negative breast cancer (TNBC) is the most aggressive type and there is no existing endocrine or targeted therapy.
Pedro H. L. Viana, Csaba A. Schvarcz, Lea O. Danics, Balázs Besztercei, Kenan Aloss, Syeda M. Z. Bokhari, Nino Giunashvili, Dániel Bócsi, Zoltán Koós, Zoltán Benyó, Péter Hamar   +10 more
doaj   +1 more source

Regulation of heat shock factor 1 (HSF1) [PDF]

, 1998
Heat shock and other proteotoxic stresses trigger the activation of a heat shock transcription factor, Heat Shock Factor 1 (HSF1) in vertebrates, which binds to promoters of heat shock or stress protein (Hsp) genes and enhances transcription from these ...
Zou, Jiangying
core  

Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival

Communications Biology
There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target.
J. Spencer Hauck, David Moon, Xue Jiang, Mu-En Wang, Yue Zhao, Lingfan Xu, Holly Quang, William Butler, Ming Chen, Everardo Macias, Xia Gao, Yiping He, Jiaoti Huang   +12 more
doaj   +1 more source

HSF1 Gene [PDF]

, 2020
openaire   +1 more source

SUMOylation is not a prerequisite for HSF1’s role in stress protection and transactivation

Scientific Reports
Targeting tumor proteostasis has emerged as a promising strategy in anticancer therapy, particularly through Hsp90 inhibition, which has shown clinical potential.
Miroslav Bardelcik, Oliver Simoncik, Kristina Bednarova, Ondrej Bonczek, Borivoj Vojtesek, Petr Muller   +5 more
doaj   +1 more source

Role of HSF1 in cell division, tumorigenesis and therapy: a literature review

Cell Division
Heat shock factor 1 (HSF1) is the master orchestrator of the heat shock response (HSR), a critical process for maintaining cellular health and protein homeostasis.
Otakar Fiser, Petr Muller
doaj   +1 more source

Hsp70-Mediated Regulation of Hsf1 Transcriptional Activity In Saccharomyces Cerevisiae [PDF]

, 2019
In eukaryotic cells, protein homeostasis and cellular fitness is promoted by the transcription factor heat shock factor 1 (HSF1) during exposure to proteotoxic stress.
Peffer, Sara
core   +1 more source

HSF1 wt Allele [PDF]

, 2020
openaire   +1 more source

HSF1 modulates lipid metabolism and ferroptosis in sarcopenia: a novel diagnostic biomarker and therapeutic target. [PDF]

Front Mol Biosci
Cheng D, Shangguan Z, Ye X, Chen G, Lin Q, Li J.   +5 more
europepmc   +1 more source

Functional interplay between heat shock protein 90 (HSP90) and heat shock factors (HSFs). [PDF]

Cell Stress Chaperones
Chakraborty A, Sistonen L, Roos-Mattjus P.   +2 more
europepmc   +1 more source