Results 121 to 130 of about 20,857 (230)

Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species–An In Silico Supported Review

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Heat stress impairs livestock performance through oxidative stress, immune dysregulation, and reduced productivity. Phytobiotics act as natural mitigators with antioxidant, anti‐inflammatory, antimicrobial, and gut‐modulatory effects. Mechanistically, they regulate HSPs, Nrf2, NF‐κB, and MAPK pathways.
Xiaoyan Wang, Ting Yuan, Muhammad Asif Arain, Mohammed Al‐Rasheed, Aftab Shaukat   +4 more
wiley   +1 more source

Direct activation of HSF1 by macromolecular crowding and misfolded proteins.

PLoS ONE
Stress responses play a vital role in cellular survival against environmental challenges, often exploited by cancer cells to proliferate, counteract genomic instability, and resist therapeutic stress.
Oliver Simoncik, Vlastimil Tichy, Michal Durech, Lenka Hernychova, Filip Trcka, Lukas Uhrik, Miroslav Bardelcik, Philip J Coates, Borivoj Vojtesek, Petr Muller   +9 more
doaj   +1 more source

Predicting Genetic Regulatory Response Using Classification

, 2004
We present a novel classification-based method for learning to predict gene regulatory response. Our approach is motivated by the hypothesis that in simple organisms such as Saccharomyces cerevisiae, we can learn a decision rule for predicting whether a ...
Freund, Yoav, Kundaje, Anshul, Leslie, Christina, Middendorf, Manuel, Wiggins, Chris   +4 more
core   +4 more sources

The Impact of Chemical Toxicants and Air Pollutants on Neurodegenerative Disorders and Their Underlying Potential Mechanisms: A Literature Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Neurodegenerative disorders are marked by progressive deterioration of neurons, affecting cognitive, memory, and motor functions. This decline creates substantial personal and social challenges, making early identification of risk factors essential for effective intervention.
Sameeha Fatima Khan, Warda Rasool, Muhammad Hamza Khan, Ganesh Kumar, Azka Ijaz, Maryam Amjad, Mahin Qudeer Sheikh, Shree Rath, Digbijay Kunwar, Anum Akbar   +9 more
wiley   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, Volume 15, Issue 4, April 2026.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

Functions of J‐domain proteins in mitochondrial protein biogenesis

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Vitasta Tiku, Georg Bossenz, Janine Kirstein, Thomas Becker   +3 more
wiley   +1 more source

Magnetic phases and reorientation transitions in antiferromagnetically coupled multilayers

, 2003
In antiferromagnetically coupled superlattices grown on (001) faces of cubic substrates, e.g. based on materials combinations as Co/Cu, Fe/Si, Co/Cr, or Fe/Cr, the magnetic states evolve under competing influence of bilinear and biquadratic exchange ...
A. Moser, A. N. Bogdanov, A. Thiaville, A. van der Graaf, A.I. Mitsek, A.L. Dantas, A.N. Bogdanov, A.N. Bogdanov, A.N. Bogdanov, A.N. Bogdanov, A.N. Bogdanov, A.N. Bogdanov, A.N. Bogdanov, B. Dieny, B. Dieny, C. Chesman, D.L. Mills, D.L. Nagy, F. Wilhelm, F.C. Nörtemann, F.Y. Wu, G. André, G.J. Strijkers, H. Itoh, H. Lauter, J.J. Picconatto, J.Z. Hilt, K. Bröhl, K. Bröhl, K. Ounadjela, K. Temst, K.-H. Müller, K.D. Myers, K.Y. Kim, L. Bottýan, M. Rührig, M.A. Howson, M.D. Stiles, M.T. Johnson, O. Hellwig, P. Grünberg, P. Steadman, P.C. Canfield, P.C. Canfield, R.W. Wang, R.W.E. van de Kruijs, S. Hamada, S.-K. Kim, S.G.E. te Velthuis, S.G.E. te Velthuis, S.O. Demokritov, S.S.P. Parkin, T. Zeidler, U. K. Rößler, U.K. Rößler, V. Lauter-Pasyuk, V. Lauter-Pasyuk, V.A. Kalatsky, V.G. Bar’yakhtar, V.V. Ustinov, Yu.V. Goryunov   +60 more
core   +1 more source

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So, In‐Kang Song, Yeon Jung Kim, Yeonjoo Lee, Yeon Seung Park, Hee‐Jung Kim, Kong‐Joo Lee, Eun Joo Song   +7 more
wiley   +1 more source

Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN

Cancer Medicine
Background Heat shock transcription factors (HSFs) play crucial roles in the development of malignancies. However, the specific roles of HSFs in hepatocellular carcinoma (HCC) have yet to be fully elucidated.Aims:To explore the involvement of the HSF ...
Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He   +4 more
doaj   +1 more source