Results 141 to 150 of about 13,678 (223)

Hsp70-Mediated Regulation of Hsf1 Transcriptional Activity In Saccharomyces Cerevisiae

, 2019
In eukaryotic cells, protein homeostasis and cellular fitness is promoted by the transcription factor heat shock factor 1 (HSF1) during exposure to proteotoxic stress.
Peffer, Sara
core  

Heat shock factor-1 alleviates ER-stress in Caenorhabditis elegans. [PDF]

Sci Rep
Ahmed S, Kovács D, Kovács M, Kosztelnik M, Hotzi B, Sigmond T, Saskői É, Vincze VV, Erdélyi V, Deák V, Stiller I, Vellai T, Barna J.   +12 more
europepmc   +1 more source

The Novel HSF1 Inhibitor NXP800 Exhibits Robust Antitumor Activity in Hepatocellular Carcinoma. [PDF]

Int J Mol Sci
Steinmann SM, Lazzari M, Kleinle A, Pischedda D, Cigliano A, Galleri G, Siegmund H, Fischer C, Piscuoglio S, Evert M, Calvisi DF.   +10 more
europepmc   +1 more source

Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network. [PDF]

Mol Cell
Halim S, Sebastian RM, Liivak KE, Patrick JE, Hui T, Amici DR, Giacomelli AO, Rios P, Butty VL, Hahn WC, Sánchez-Rivera FJ, Mendillo ML, Lin YS, Shoulders MD.   +13 more
europepmc   +1 more source

Activation of the heat shock response as a therapeutic strategy for tau toxicity

Disease Models & Mechanisms
Taylor R. Stanley, Elizabeth M. Otero, Amy L. Knight, Aleen D. Saxton, Xinxing Ding, Melissa Borgen, Brian C. Kraemer, Karen S. Kim Guisbert, Eric Guisbert   +8 more
doaj   +1 more source

EP300 confers protection against acute pancreatitis via acetylating HSF1 and promoting PRKN-mediated mitophagy in pancreatic acinar cells. [PDF]

Cell Commun Signal
Zhu L, Qi Z, Fan Y, Tan S, Chen H, Liu K, Zhang H, Wang K, Wang N.   +8 more
europepmc   +1 more source

Discovery of Thermal Sensitizers That Inhibit Heat-Induced SAFB Granule Formation. [PDF]

J Med Chem
Furutani Y, Shimasaki N, Yamada R, Ohtsuki T, Watanabe K.   +4 more
europepmc   +1 more source

<i>ACTA2</i> Pathogenic Variants Activating Heat Shock Factor 1 and Increasing Cholesterol Biosynthesis in Smooth Muscle Cells Predispose to Early Onset Atherosclerosis. [PDF]

Circ Genom Precis Med
Boerio ML, Chattopadhyay A, Duan XY, Karla A, Calderon Martinez E, Pinard A, Morse AK, Reddy D, Dharma S, Velasco-Torrez W, Marcadier J, Prakash SK, Shalhub S, De Backer J, Jeremy R, Morris SA, Yetman AT, Braverman AC, Milewicz DM.   +18 more
europepmc   +1 more source

Skeletal Muscle HSF1 Alleviates Age-Associated Sarcopenia and Mitochondrial Function Decline via SIRT3-PGC1α Axis. [PDF]

Adv Sci (Weinh)
Zhang J, Hu M, Wu X, Guo M, Ma Y, Qiu J, Wang S, Cao Y, Zhong Y, Chen F, Wang Y, Wei W, Lu Y, Zhang Y, Xiao J, Gan Z, Hu C, Ma X, Xu L.   +18 more
europepmc   +1 more source

Dual inhibition of mTOR and HSP90 enhances cisplatin efficacy and overcomes resistance in ovarian cancer. [PDF]

Cell Death Dis
Lombardi R, Addi L, Pucci B, Bruzzese F, Sonego M, Nespolo A, Roca MS, Iannelli F, Alfano L, Capone F, Di Gennaro E, Baldassarre G, Budillon A.   +12 more
europepmc   +1 more source