Results 131 to 140 of about 20,857 (230)

Rsp5 promotes Gene Activation mediated by 9aaTAD Transcription Factors Oaf1 and Gal4 [PDF]

, 2009
Nine-amino-acid transactivation domain, 9aaTAD, defines a large superfamily of yeast and mammals transcription factors. The transactivation of the 9aaTAD has been addressed to multiple general co-activators TAF9, MED15, CBP and p300.
Joachim Lipp, Manfred Koranda, Martin Piskacek   +2 more
core   +1 more source

Aging cellular networks: chaperones as major participants

, 2006
We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to link the network
Agoston, Barabasi, Blais, Borodina, C. Sőti, Chan, Cherian, Cowen, Csermely, Csermely, Csermely, Csermely, Donaldson, Dorogovtsev, Dukan, Fares, Ferrarini, Gavin, Goldberger, Hayflick, He, Herndon, Heydari, Himmelstein, Imai, Irish, Macario, Morimoto, Mukai, Nardai, Nardai, Nollen, P. Csermely, Paulsson, Promislow, Pál, Queitsch, Rual, Rutherford, Schwarzer, Song, Stadtman, Stelzl, Sőti, Sőti, Sőti, Sőti, von Mering, Werner-Washburne, Westerheide, White, Yam, Young, Young, Zhao, Zhu, Zou   +56 more
core   +1 more source

A Novel Approach of Virotherapy Based Hsf-1 Shrna in Cancer Eradication [PDF]

, 2013
Cancer is the second leading cause of death worldwide with continues rise mortality rate. Current cancer treatment modalities are still ineffective and associated with many side effects leading to robust research to find new specific target therapy. Heat
Supadmanaba, I. G. (I), Wibawa-Manuaba, I. B. (I)   +1 more
core  

A Novel HSF1-mediated Death Pathway

Yamaguchi Medical Journal, 2007
熱ショック転写因子 (heat shock transcription factor, HSF) は，一群の熱ショック蛋白質 (heat shock protein, Hsp) の発現制御に関わる転写因子群として知られ，哺乳動物細胞では３種類のHSF (HSF1, HSF2, HSF4) が明らかにされている．このうち，HSF1は蛋白質の変性を感知し，Hspの発現制御において中心的な役割を担い，温熱ストレスをはじめとする様々なストレスに対する耐性の獲得を通して細胞生存に働いている．一方，我々は活性型HSF1トランスジェニックマウス，ならびに HSF1欠損マウスの解析から，HSF1が細胞死を導く働きがあることを示唆する結果を得ていた．本稿では ...
openaire   +2 more sources

HSP90 Family Members, Their Regulators and Ischemic Stroke Risk: A Comprehensive Molecular-Genetics and Bioinformatics Analysis

Frontiers in Bioscience-Scholar
Background: Disruptions in proteostasis are recognized as key drivers in cerebro- and cardiovascular disease progression. Heat shock proteins (HSPs), essential for maintaining protein stability and cellular homeostasis, are pivotal in ...
Ksenia Kobzeva, Maxim Ivenkov, Rostislav Gromov, Olga Bushueva   +3 more
doaj   +1 more source

Heat shock factor 1 promotes proliferation and chemoresistance in diffuse large B-cell lymphoma by enhancing the cell cycle and DNA repair

Cell Death and Disease
Diffuse large B-cell lymphoma (DLBCL) is commonly treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), but up to 40% of patients have refractory or relapsing disease and show unsatisfactory responses to salvage ...
Yu Fang, Liang Cheng, Ming Huang, Yi Cao, Qihua Zou, Jun Cai, Yuchen Zhang, Yi Xia, Huiqiang Huang, Xu Chen, Qingqing Cai   +10 more
doaj   +1 more source

Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model

Scientific Reports
Female breast cancer is the most diagnosed cancer worldwide. Triple negative breast cancer (TNBC) is the most aggressive type and there is no existing endocrine or targeted therapy.
Pedro H. L. Viana, Csaba A. Schvarcz, Lea O. Danics, Balázs Besztercei, Kenan Aloss, Syeda M. Z. Bokhari, Nino Giunashvili, Dániel Bócsi, Zoltán Koós, Zoltán Benyó, Péter Hamar   +10 more
doaj   +1 more source

Low-temperature ordered phases of the spin-$\frac{1}{2}$ XXZ chain system Cs$_2$CoCl$_4$

, 2014
In this study the magnetic order of the spin-1/2 XXZ chain system Cs$_2$CoCl$_4$ in a temperature range from 50 mK to 0.5 K and in applied magnetic fields up to 3.5 T is investigated by high-resolution measurements of the thermal expansion and the ...
Becker, P., Bohaty, L., Breunig, O., Buldmann, B., Garst, M., Lorenz, T., Müller, R., Rosch, A., Sela, E.   +8 more
core   +1 more source

Widening HSF1 horizon: the microRNA connection

RNA & DISEASE, 2015
Heat shock factor 1 (HSF1) is an evolutionary conserved transcription factor, which acts as protector of cellular proteome against adverse environmental conditions including increased temperature in eukaryotes. HSF1 positively regulates expression of a set of cytoprotective proteins popularly called as heat shock proteins (HSPs) as part of an adaptive ...
openaire   +1 more source

Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression

Neoplasia: An International Journal for Oncology Research
Background: Glioblastoma (GBM) poses a significant medical challenge due to its aggressive nature and poor prognosis. Mitochondrial unfolded protein response (UPRmt) and the heat shock factor 1 (HSF1) pathway play crucial roles in GBM pathogenesis.
Xiang Li, Zongqi Wang, Bixi Gao, Kun Dai, Jiang Wu, Kecheng Shen, Guangzhao Li, Xiaowang Niu, Xin Wu, Longyuan Li, Haitao Shen, Haiying Li, Zhengquan Yu, Zhong Wang, Gang Chen   +14 more
doaj   +1 more source