Results 101 to 110 of about 13,686 (217)

Regulation of HSF1 serine 326 phosphorylation during stress. [PDF]

, 2013
(A) Levels of HSF1-phosphoserine 326, total HSF1 and β-actin in HeLa cells treated with heat at 43°C for 30 min and recovered at 37°C for up to 24hr. (B) Levels of HSF1-phosphoserine 326, HSF1-phosphoserine 303, HSF1-phosphoserine 320, total HSF1, mTOR ...
Shiuh-Dih Chou (237909), Stuart K. Calderwood (191496), Jianlin Gong (317368), Thomas Prince (191492)   +3 more
core   +1 more source

CRISPR Screen Reveals Pathways and Factors Driving Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 8, August 2026.
One thousand nine hundred sixty‐two genes associated with HCC TKI treatment responsiveness were identified through an internal unbiased genome‐wide CRISPR/Cas9 screening. A comprehensive HCC TKI treatment response landscape was constructed by integrating 20 datasets comprising a total of 322 TKI‐treated or TKI‐resistant HCC samples.
Si‐Yu Chen, Li‐Hua Yang, Zi‐Qian Liang, Jian‐Di Li, Shi‐de Li, Yu‐Long Deng, Guo‐Qiang Chen, Jing‐Wen Ling, Sheng‐Sheng Zhou, Gang Chen, Rong‐Quan He   +10 more
wiley   +1 more source

Cardiovascular Diseases and Cancer: Convergent Proteostasis Networks at the Crossroads of Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
The disruption of proteostasis, encompassing the ubiquitin–proteasome system, autophagy, UPR/ER stress, and chaperone function, represents a fundamental mechanism shared by both cancer and cardiovascular diseases. While these pathways frequently facilitate tumor progression, they are crucial for maintaining proteostasis in cardiac tissue. Consequently,
Jacob Eli García Torres, Norbert Frey, Ashraf Yusuf Rangrez   +2 more
wiley   +1 more source

HSF1 mediated stress response of heavy metals

PLOS ONE, 2018
The heat shock response (HSR) pathway is a highly conserved cellular stress response and mediated by its master regulator HSF1. Activation of the pathway results in the expression of chaperone proteins (heat shock proteins; HSP) to maintain protein homeostasis. One of the genes strongest upregulated upon stress is HSPA1A (HSP72).
Christoph Steurer, Noreen Eder, Sarah Kerschbaum, Christina Wegrostek, Stefan Gabriel, Natalia Pardo, Viktoria Ortner, Thomas Czerny, Elisabeth Riegel   +8 more
openaire   +3 more sources

MYC in Oncogenesis and Therapeutic Implications

MedComm, Volume 7, Issue 8, August 2026.
The MYC oncogene family (c‐MYC, N‐MYC, L‐MYC) functions as a central transcriptional hub orchestrating cancer progression through multiple interconnected pathways. This graphical abstract illustrates MYC's role as a multidimensional regulator positioned at the nexus of tumor microenvironment remodeling, metabolic reprogramming, and therapeutic ...
Na Zhang, Li Wei, Cuiping Tang, Peilong Lai, Wenbin Zhong, Hua You   +5 more
wiley   +1 more source

HSF1 down-regulates XAF1 through transcriptional regulation [PDF]

, 2006
Studies have indicated the role of HSF1 (heat-shock transcription factor 1) in repressing the transcription of some nonheat shock genes. XAF1 (XIAP-associated factor 1) was an inhibitor of apoptosis-interacting protein with the effect of antagonizing the
Yu, L, Gu, Q, An, X, Wang, J, He, H, Xia, HHX, Li, M, Kung, HF, Wong, BCY, Zou, B, Lin, MCM, Jiang, B   +11 more
core   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, Volume 59, Issue 8, August 2026.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

RhoA activation inhibits HSF1 transcriptional activity by suppressing HSF1 binding to HSE, which is independent of HSF1 translocation and post-translational modifications. [PDF]

, 2015
(A) Nuclear accumulation of HSF1 in response to HS with and without RhoA modulation by calpeptin [Calp] in cardiomyocytes. (B) HSF1 and RhoA levels in TX-100 soluble cytosolic fractions and nuclear-containing fractions of cells with and without HS and ...
Denise M. S. van Marion (772828), Femke Hoogstra-Berends (217817), Deli Zhang (240106), Robert H. Henning (108507), Harm H. Kampinga (82770), Thomas Wieland (413227), Martina Schmidt (183309), Marit Wiersma (772827), Anne-Jan Dijkhuis (772829), Roelien A. M. Meijering (217816), Bianca J. J. M. Brundel (217820)   +10 more
core   +1 more source

HSF1 is required for cellular adaptation to daily temperature fluctuations

Scientific Reports
The heat shock response (HSR) is a universal mechanism of cellular adaptation to elevated temperatures and is regulated by heat shock transcription factor 1 (HSF1) or HSF3 in vertebrate endotherms, such as humans, mice, and chickens.
Ryosuke Takii, Mitsuaki Fujimoto, Akanksha Pandey, Kritika Jaiswal, Linda Shearwin-Whyatt, Frank Grutzner, Akira Nakai   +6 more
doaj   +1 more source

Overexpression or depletion of HSF1 induces filamentation. [PDF]

, 2018
a) HSF1 levels can be overexpressed to different levels by placing one or both alleles of HSF1 under the control of the tetracycline-repressible promoter, tetO. Strains were grown in the absence of doxycycline (DOX) to mid-log phase.
Malcolm Whiteway (30367), Nicole Robbins (206417), Amanda O. Veri (3163503), Sang Hu Kim (828778), Rebecca S. Shapiro (137939), Zhengqiang Miao (538787), Teresa R. O’Meara (720286), Faiza Tebbji (141832), Juan Colazo (4234498), Koon Ho Wong (5028644), Leah E. Cowen (108693), Valmik K. Vyas (427501), Kaeling Tan (192448)   +12 more
core   +1 more source