Results 101 to 110 of about 13,678 (223)

Investigating the HSF1-HSF2 Interaction

, 2017
The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a cell, a class of proteins known
Jaeger, Alex, Wacker, Bryan, Thiele, Dennis, Ph.D.   +2 more
core  

HSF1 is required for cellular adaptation to daily temperature fluctuations

Scientific Reports
The heat shock response (HSR) is a universal mechanism of cellular adaptation to elevated temperatures and is regulated by heat shock transcription factor 1 (HSF1) or HSF3 in vertebrate endotherms, such as humans, mice, and chickens.
Ryosuke Takii, Mitsuaki Fujimoto, Akanksha Pandey, Kritika Jaiswal, Linda Shearwin-Whyatt, Frank Grutzner, Akira Nakai   +6 more
doaj   +1 more source

HSF1 inhibition attenuates cancer cell survival.

, 2014
(A) iaRNAHSF1 expression does not affect normal cells (IMR90), yet induces an abnormal morphology in HeLa cervical carcinoma and chemically transformed kidney cells (293T). (B).
Richard A. Cerione (464912), John T. Lis (7283), H. Hans Salamanca (560402), Marc A. Antonyak (560403), Hua Shi (7282)   +4 more
core   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, Volume 59, Issue 6, June 2026.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

S303 phosphorylation of HSF1 in yeast is modulated by Slt2.

, 2013
(A) PS145 and LNY2 (slt2Δ) were transformed with a plasmid expressing wild-type HSF1 and were grown on galactose containing medium. Total protein extracts were analyzed for pS303, total HSF1 and Pgk1 by immunoblotting. (B) PS145 (WT) expressing wild-type
Claudina Rodrigues-Pousada (164208), Dennis J. Thiele (227319), Daniel W. Neef (254588), Phillip C. C. Liu (357929), Liliana Batista-Nascimento (357926)   +4 more
core   +1 more source

Direct activation of HSF1 by macromolecular crowding and misfolded proteins.

PLoS ONE
Stress responses play a vital role in cellular survival against environmental challenges, often exploited by cancer cells to proliferate, counteract genomic instability, and resist therapeutic stress.
Oliver Simoncik, Vlastimil Tichy, Michal Durech, Lenka Hernychova, Filip Trcka, Lukas Uhrik, Miroslav Bardelcik, Philip J Coates, Borivoj Vojtesek, Petr Muller   +9 more
doaj   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, Volume 293, Issue 11, Page 3187-3210, June 2026.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Potential targets for HSF1 within the preinitiation complex

Cell Stress & Chaperones, 2000
Protein-protein interactions between human heat shock transcription factor 1 (hHSF1) and general transcription factors TFIIA-gamma, TFIIB, TBP, TAF(II)32, and TAF(II)55 and positive coactivator PC4 were characterized in order to identify potential targets of contact in the transcriptional preinitiation complex. These contacts represent one of the final
C X, Yuan, W B, Gurley
openaire   +3 more sources

Breaking the Heat Tolerance Response: The Crucial Role of MFAP4 in Combating Heat‐Induced Cardiac Injury

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
MFAP4 deficiency exacerbates heatstroke outcomes, accelerating hyperthermia, delaying recovery, reducing survival, and worsening cardiac injury. Conversely, MFAP4 overexpression enhances cellular thermoresistance. MFAP4 orchestrates transcriptional reprogramming in response to HS.
LiJun Fan, MingXiao Song, QingHan Zhang, ZiYi Guo, Jing Wang, XueWei Chen, ChenYi Hu, JunYu Lu, ZhuGe Xi   +8 more
wiley   +1 more source

Interactions between extracellular Hsp72 and blood cells [PDF]

, 2010
Not to be added to EThOSIn recent years, compelling evidence has accumulated suggesting heat shock proteins (HSPs) which are generally believed to be localised and functioning mainly within eukaryotic cells as cyto-protective molecular chaperones, are ...
Williams, Helen
core