Results 101 to 110 of about 20,857 (230)
Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]
, 2017 Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core +2 more sources
Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
Advanced Genetics, Volume 7, Issue 2, June 2026.This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley +1 more source
HSF1 overexpression enhances oncolytic effect of replicative adenovirus [PDF]
Journal of Translational Medicine, 2010 Abstract Background E1B55kD deleted oncolytic adenovirus was designed to achieve cancer-specific cytotoxicity, but showed limitations in clinical study. To find a method to increase its efficacy, we investigated the correlation between oncolytic effect of such oncolytic adenovirus Adel55 and intracellular heat shock ...
Deng Youwen +5 more
openaire +3 more sources
Protein Science, Volume 35, Issue 5, May 2026.Abstract Intrinsically disordered regions (IDRs) play important molecular roles in cells even though they do not adopt a stable structure. Relative to structured regions, IDRs have skewed amino acid compositions favoring polar and charged amino acids. This feature is a major contributor to the biophysical behavior and in vivo activity of IDRs, but the ...
Sean M. Cascarina +3 more
wiley +1 more source
A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a [PDF]
, 2011 Hsp90α's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and cell lines validates it as a therapeutic target for glioma.
Adi Mehta +55 more
core +2 more sources
Quality control of protein import into mammalian mitochondria
Protein Science, Volume 35, Issue 5, May 2026.Abstract Mitochondrial function depends on the continuous import of hundreds of nuclear‐encoded proteins. Targeting and translocation of mitochondrial proteins is a multistep process that is inherently vulnerable to defects in cytosolic quality control systems as well as perturbations in mitochondrial protein import machinery and organelle function ...
Madeleine Goldstein +2 more
wiley +1 more source
Reply to Christians: Hsf1 Knock-out
Journal of Biological Chemistry, 2011 This is a response to a letter by Christians (1) In response to the letter by Christians asserting viability of HSF-1 knock-out (KO) mice, we acknowledge that our statement that “the homozygous mice are lethal” was an oversimplification, and we apologize for this. To set the record straight, HSF-1 KO mice have been created, and a small percentage of
W. Keith Jones, Michael Tranter
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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis [PDF]
, 2018 Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated with massive protein ...
Airoldi, Edoardo M. +7 more
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Journal of Diabetes, Volume 18, Issue 5, May 2026.This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li +5 more
wiley +1 more source
Effects of LRP1B Regulated by HSF1 on Lipid Metabolism in Hepatocellular Carcinoma
Journal of Hepatocellular Carcinoma, 2020 Miaomiao Li,1,* Juntao Hu,2,* Riming Jin,3,* Hongxia Cheng,1 Huaping Chen,4 Limin Li,4 Kun Guo1 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People ...
Li M +6 more
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