Results 61 to 70 of about 13,686 (217)

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

DNA binding of HSF1 to HSE after heat shock. [PDF]

, 2013
Endogenous and full-length HSF1, but not HSF1 mutants, only bind to HSE. The biotinylated double-stranded oligonucleotides harboring the HSE motif were incubated with cellular extracts obtained from cell lines expressing the full length HSF1-eGFP (wt ...
Antoine Delon (431449), Claire Vourc’h (431448), Gaëtan Herbomel (431444), Yves Usson (431447), Eric G. Folco (310374), Catherine Souchier (431450), Meike Kloster-Landsberg (431445), Edwige Col (431446)   +7 more
core   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

HSF1 is involved in immunotherapeutic response through regulating APOJ/STAT3-mediated PD-L1 expression in hepatocellular carcinoma

Cancer Biology & Therapy, 2023
Hepatocellular cancer (HCC) is a serious illness with high prevalence and mortality throughout the whole world. For advanced HCC, immunotherapy is somewhat impactful and encouraging.
Hongxia Cheng, Sikai Wang, Aidan Huang, Jing Ma, Dongmei Gao, Miaomiao Li, Huaping Chen, Kun Guo   +7 more
doaj   +1 more source

Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu, I. A. Anjola, L. O. Fasasi, D. P. Fadipe, A. T. Afuye, F. O. Fasanya, O. E. Oke   +6 more
wiley   +1 more source

Data from HSF1 as a Mitotic Regulator: Phosphorylation of HSF1 by Plk1 Is Essential for Mitotic Progression

, 2023
<div>Abstract<p>Previously, heat shock factor 1 (HSF1) had been reported to induce genomic instability and aneuploidy by interaction with Cdc20. Here, we have further examined the functions of HSF1 in the regulation of mitosis. A null mutant or knockdown of HSF1 caused defective mitotic progression. By monitoring chromosomes in living cells,
Yun-Sil Lee, Seung Hae Kwon, Sangwoo Bae, Dooil Jeoung, Jae Seon Lee, Eun-Ho Kim, Yoon-Jin Lee   +6 more
openaire   +1 more source

HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms

Frontiers in Cell and Developmental Biology
Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1’s role in chemoresistance and its potential
Shruti Ghai, Rejina Shrestha, Kuo-Hui Su
doaj   +1 more source

Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

eLife, 2018
Models for regulation of the eukaryotic heat shock response typically invoke a negative feedback loop consisting of the transcriptional activator Hsf1 and a molecular chaperone.
Joanna Krakowiak, Xu Zheng, Nikit Patel, Zoë A Feder, Jayamani Anandhakumar, Kendra Valerius, David S Gross, Ahmad S Khalil, David Pincus   +8 more
doaj   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

The Role of HSF1 Protein in Malignant Transformation

Klinicka onkologie, 2018
The heat shock transcription factor, HSF1, is the main regulator of the proteotoxic stress response that orchestrates the adaptation of cells to stress conditions such as elevated temperature, oxidative stress, and proteotoxic stress. As such, HSF1 regulates a large number of stress response-related genes, primarily those encoding heat shock proteins ...
Oliver, Šimončík, Michal, Pastorek, Bořivoj, Vojtěšek, Petr, Müller   +3 more
openaire   +2 more sources