Results 61 to 70 of about 13,678 (223)
S303 phosphorylation represses HSF1 activity in yeast.
, 2013 (A) PS145 yeast strains expressing wild-type HSF1 (WT) or the S303A, S307A or S303/307A mutants were plated on either galactose or dextrose supplemented medium.
Claudina Rodrigues-Pousada (164208) +4 more
core +1 more source
, 2023 <div>Abstract<p>Previously, heat shock factor 1 (HSF1) had been reported to induce genomic instability and aneuploidy by interaction with Cdc20. Here, we have further examined the functions of HSF1 in the regulation of mitosis. A null mutant or knockdown of HSF1 caused defective mitotic progression. By monitoring chromosomes in living cells,
Yun-Sil Lee +6 more
openaire +1 more source
Frontiers in Cell and Developmental BiologyHeat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1’s role in chemoresistance and its potential
Shruti Ghai, Rejina Shrestha, Kuo-Hui Su
doaj +1 more source
Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response
eLife, 2018 Models for regulation of the eukaryotic heat shock response typically invoke a negative feedback loop consisting of the transcriptional activator Hsf1 and a molecular chaperone.
Joanna Krakowiak +8 more
doaj +1 more source
Cancer Biology & Therapy, 2023 Hepatocellular cancer (HCC) is a serious illness with high prevalence and mortality throughout the whole world. For advanced HCC, immunotherapy is somewhat impactful and encouraging.
Hongxia Cheng +7 more
doaj +1 more source
HSF1 is activated during VACV infection.
, 2014 (A) Immunoblot showing HSF1 is phosphorylated on S326 following heat shock (42°C; lane 1). Basal levels of HSF1 phosphorylation are seen in mock and VACV infected cells 30 minutes post infection (lanes 2 and 3).
Lisa E. Hensley (202167) +12 more
core +1 more source
S303 and S307 repress HSF1 activity in hsf1−/− MEFs.
, 2013 (A) hsf1−/− MEFs were transfected with an empty vector or plasmids expressing wild-type HSF1 or the S303A, S307A or the S303/307A mutants. The transfected cells were treated with DMSO solvent or MG132 (10 µM) for 5 h. Total protein extracts were analyzed
Claudina Rodrigues-Pousada (164208) +4 more
core +1 more source
Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies
Animal Research and One Health, EarlyView.Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu +6 more
wiley +1 more source
Hsf1 from A. franciscana shares sequence identity with Hsf1 from other organisms.
, 2018 Hsf1 from A. franciscana shares sequence identity with Hsf1 from other organisms.
Jiabo Tan (5488778) +1 more
core +1 more source
CK2-mediated phosphorylation regulates BMAL1-HSF1 binding.
, 2013 (A) WT MEFs were cOS-pulsed. At the indicated time, BMAL1- and HSF-IP and lysates were analyzed by immunoblotting for BMAL1, phospho-BMAL1-S90 (pBMAL1-S90), HSF1, phospho-HSF1-T142 (pHSF1-T142), CK2alpha, CK2beta, and actin.
Teruya Tamaru (344719) +11 more
core +1 more source