Results 41 to 50 of about 13,678 (223)
Angewandte Chemie, EarlyView.Hsf1 undergoes phase separation around target DNA, activating stress‐responsive transcription. DNA binding tunes conformational dynamics of Hsf1DBD, which propagates through large‐scale domain rearrangements involving DBD–IDR interactions to regulate phase separation. This hierarchical framework illustrates how local structural events at the side chain
Soichiro Kawagoe +2 more
wiley +2 more sources
Cell Reports, 2018 Summary: Clonal populations of cells exhibit cell-to-cell variation in the transcription of individual genes. In addition to this noise in gene expression, heterogeneity in the proteome and the proteostasis network expands the phenotypic diversity of a ...
Xu Zheng +5 more
doaj +1 more source
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model
Mediators of Inflammation, 2023 Background. Sepsis, which could cause a systemic inflammatory response, is a life-threatening disease with a high morbidity and mortality rate. There is evidence that brain injury may be related to severe systemic infection induced by sepsis.
Yi-fu He +8 more
doaj +1 more source
PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element
Cells, 2022 At present, the barrier to HIV-1 functional cure is the persistence of HIV-1 reservoirs. The “shock (reversing latency) and kill (antiretroviral therapy)” strategy sheds light on reducing or eliminating the latent reservoir of HIV-1. However, the current
Xinfeng Xu +10 more
doaj +1 more source
, 2012 (A) Inhibiting Hsp90 with geldanamycin leads to Hsf1 activation. C. albicans cells were incubated with 20 µM geldanamycin for one hour, and Hsf1 phosphorylation examined by western blotting. (B) Depleting Hsp90 leads to Hsf1 activation.
Carol Munro (108688) +5 more
core +1 more source
Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively. [PDF]
PLoS ONE, 2014 Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood ...
Inbal Nussbaum +4 more
doaj +1 more source
HSF1 knockdown inhibits VACV infection.
, 2014 Five independent shRNAs targeting HSF1 were used to knockdown protein expression in A549 cells. The levels of HSF1 remaining after selection were quantified by immunoblot with several antibodies. (A) Representative immunoblot (anti-HSF1 J7F9).
Lisa E. Hensley (202167) +12 more
core +1 more source
Journal of Biological Chemistry, 2011 In the recent article by Tranter et al. (1), it is indicated that homozygous Hsf1 (knock-out) mice are not viable. This information as mentioned was not supported by any reference. As statements provided in scientific papers need to be accurate, I would like to provide the following additional information and correction.
openaire +2 more sources
, 2023 Western blot data for HSF1 and GAPDH. Blot using chemiluminescence to show HSF1 and GAPDH.Blot using bright field to show ladder.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Holman, A (via Mendeley Data)
core +2 more sources
The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model. [PDF]
PLoS ONE, 2016 Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. The proteotoxic stress-responsive transcription factor HSF1 is frequently overexpressed in a variety of ...
Chase D Powell +5 more
doaj +1 more source