Results 41 to 50 of about 13,686 (217)
HSF1, A Versatile Factor in Tumorogenesis [PDF]
Current Molecular Medicine, 2012 HSF1 is an essential factor in the acute response to proteotoxic stress, in which it causes rapid transcription of heat shock protein (HSP) genes in order to permit survival of cells and restoration of global protein quality. In addition to this property however, HSF1 is chronically activated or overexpressed in a wide range of cancers and is essential
openaire +2 more sources
HSF1 is activated during VACV infection. [PDF]
, 2014 (A) Immunoblot showing HSF1 is phosphorylated on S326 following heat shock (42°C; lane 1). Basal levels of HSF1 phosphorylation are seen in mock and VACV infected cells 30 minutes post infection (lanes 2 and 3).
Lisa E. Hensley (202167) +12 more
core +1 more source
S303 and S307 repress HSF1 activity in hsf1−/− MEFs. [PDF]
, 2013 (A) hsf1−/− MEFs were transfected with an empty vector or plasmids expressing wild-type HSF1 or the S303A, S307A or the S303/307A mutants. The transfected cells were treated with DMSO solvent or MG132 (10 µM) for 5 h. Total protein extracts were analyzed
Claudina Rodrigues-Pousada (164208) +4 more
core +1 more source
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model
Mediators of Inflammation, 2023 Background. Sepsis, which could cause a systemic inflammatory response, is a life-threatening disease with a high morbidity and mortality rate. There is evidence that brain injury may be related to severe systemic infection induced by sepsis.
Yi-fu He +8 more
doaj +1 more source
Molecularchaperones as HSF1-specific transcriptional repressors [PDF]
Genes & Development, 1998 The rapid yet transient transcriptional activation of heat shock genes is mediated by the reversible conversion of HSF1 from an inert negatively regulated monomer to a transcriptionally active DNA-binding trimer. During attenuation of the heat shock response, transcription of heat shock genes returns to basal levels and HSF1 reverts to an inert monomer.
Shi, Yanhong +2 more
openaire +3 more sources
Hsf1 from A. franciscana shares sequence identity with Hsf1 from other organisms. [PDF]
, 2018 Hsf1 from A. franciscana shares sequence identity with Hsf1 from other organisms.
Jiabo Tan (5488778) +1 more
core +1 more source
Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast. [PDF]
PLoS ONE, 2011 Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that include protein
Liliana Batista-Nascimento +4 more
doaj +1 more source
CK2-mediated phosphorylation regulates BMAL1-HSF1 binding. [PDF]
, 2013 (A) WT MEFs were cOS-pulsed. At the indicated time, BMAL1- and HSF-IP and lysates were analyzed by immunoblotting for BMAL1, phospho-BMAL1-S90 (pBMAL1-S90), HSF1, phospho-HSF1-T142 (pHSF1-T142), CK2alpha, CK2beta, and actin.
Teruya Tamaru (344719) +11 more
core +1 more source
Cell Reports, 2018 Summary: Clonal populations of cells exhibit cell-to-cell variation in the transcription of individual genes. In addition to this noise in gene expression, heterogeneity in the proteome and the proteostasis network expands the phenotypic diversity of a ...
Xu Zheng +5 more
doaj +1 more source
Is there a role for HSF1 in viral infections?
FEBS Open Bio, 2022 Cells undergo numerous processes to adapt to new challenging conditions and stressors. Heat stress is regulated by a family of heat shock factors (HSFs) that initiate a heat shock response by upregulating the expression of heat shock proteins (HSPs) intended to counteract cellular damage elicited by increased environmental temperature.
Antonia Reyes +4 more
openaire +3 more sources