Results 21 to 30 of about 13,678 (223)

Interaction between Maslinic acid and HSF1 enhances the ubiquitin degradation of HSF1, resulting in the inhibitory effect of pancreatic cancer

Discover Oncology
Maslinic acid (MA), a pentacyclic triterpenoid, displays broad biological activity including anti-inflammatory, antihyperlipidemic, anti-tumor, cardiovascular protection etc.
Yuxi Zhang, Mingyue Guo, Hanlin Ye, Li Cheng, Xiukun Lin, Linlin Wang, Gan Qiao, Ammad Ahmad Farooqi   +7 more
core   +4 more sources

HSF1 at a glance [PDF]

Journal of Cell Science, 2014
ABSTRACTHeat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription factor that coordinates stress-induced transcription and directs versatile physiological processes in eukaryotes. The central position of HSF1 in cellular homeostasis has been well demonstrated, mainly through its strong effect in transactivating genes that encode ...
Vihervaara A, Sistonen L
openaire   +3 more sources

HSF1 Can Prevent Inflammation following Heat Shock by Inhibiting the Excessive Activation of the ATF3 and JUN&FOS Genes

Cells, 2022
Heat Shock Factor 1 (HSF1), a transcription factor frequently overexpressed in cancer, is activated by proteotoxic agents and participates in the regulation of cellular stress response.
Patryk Janus, Paweł Kuś, Natalia Vydra, Agnieszka Toma-Jonik, Tomasz Stokowy, Katarzyna Mrowiec, Bartosz Wojtaś, Bartłomiej Gielniewski, Wiesława Widłak   +8 more
doaj   +1 more source

β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer

Molecular Cancer, 2020
Background Heat shock transcription factor1 (HSF1) was overexpressed to promote glutaminolysis and activate mTOR in colorectal cancer (CRC). Here, we investigated the mechanism for cancer-specific overexpression of HSF1.
Ping Song, Lifeng Feng, Jiaqiu Li, Dongjun Dai, Liyuan Zhu, Chaoqun Wang, Jingyi Li, Ling Li, Qiyin Zhou, Rongkai Shi, Xian Wang, Hongchuan Jin   +11 more
doaj   +1 more source

Manipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression. [PDF]

PLoS ONE, 2010
BACKGROUND: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in the Xenopus tadpole.
Ron P Dirks, Remon van Geel, Sanne M M Hensen, Siebe T van Genesen, Nicolette H Lubsen   +4 more
doaj   +1 more source

Effects of FBXW7α on Expression and Localization of Heat Shock Transcription Factor 1 in Colorectal Cancer Cells

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the effect of FBXW7 on the expression and localization of HSF1 in colorectal cancer cells. Methods The expression levels of HSF1 and pHSF1Ser326 protein in FBXW7 deletion (KO) and wild-type (WT) FBXW7-expressing counterpart ...
SUN Ao, JIAO Han, FU Jiejun
doaj   +1 more source

Heat shock factor 1 suppression induces spindle abnormalities and sensitizes cells to antimitotic drugs

Cell Division, 2021
Background Heat shock factor 1 (HSF1) is the master regulator of the heat shock response and supports malignant cell transformation. Recent work has shown that HSF1 can access the promoters of heat shock proteins (HSPs) and allow HSP expression during ...
Hsiao-Hui Kuo, Zhi-Rou Su, Jing-Yuan Chuang, Ling-Huei Yih   +3 more
doaj   +1 more source

The HSF1-CPT1a Pathway Is Differentially Regulated in NAFLD Progression

Cells, 2022
Obesity and obesity-associated diseases represent one of the key health challenges of our time. In this context, aberrant hepatic lipid accumulation is a central pathological aspect of non-alcoholic fatty liver disease (NAFLD).
Wiebke Breternitz, Friedrich Sandkühler, Frauke Grohmann, Jochen Hampe, Mario Brosch, Alexander Herrmann, Clemens Schafmayer, Christian Meinhardt, Stefan Schreiber, Alexander Arlt, Claudia Geismann   +10 more
doaj   +1 more source

Protein kinase A regulates molecular chaperone transcription and protein aggregation. [PDF]

PLoS ONE, 2011
Heat shock factor 1 (HSF1) regulates one of the major pathways of protein quality control and is essential for deterrence of protein-folding disorders, particularly in neuronal cells.
Yue Zhang, Ayesha Murshid, Thomas Prince, Stuart K Calderwood   +3 more
doaj   +1 more source

Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection. [PDF]

PLoS ONE, 2008
BACKGROUND: Induction of the heat shock response (HSR) and increased expression of the heat shock proteins (HSPs) provide mechanisms to ensure proper protein folding, trafficking, and disposition.
Jingxian Yang, Kristen Bridges, Kuang Yu Chen, Alice Y-C Liu   +3 more
doaj   +1 more source