Results 21 to 30 of about 13,686 (217)
Heat Shock Proteins and HSF1 in Cancer [PDF]
Frontiers in Oncology, 2022 Fitness of cells is dependent on protein homeostasis which is maintained by cooperative activities of protein chaperones and proteolytic machinery. Upon encountering protein-damaging conditions, cells activate the heat-shock response (HSR) which involves HSF1-mediated transcriptional upregulation of a group of chaperones – the heat shock proteins (HSPs)
Anna M. Cyran, Anatoly Zhitkovich
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Journal of Cell Science, 2014 ABSTRACTHeat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription factor that coordinates stress-induced transcription and directs versatile physiological processes in eukaryotes. The central position of HSF1 in cellular homeostasis has been well demonstrated, mainly through its strong effect in transactivating genes that encode ...
Vihervaara A, Sistonen L
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Expression levels of HSF1 and HSF1-eGFP in stable HeLa cell lines. [PDF]
, 2013 HSF1 western blotting of full protein extracts before (−) and after one hour heat shock (+), before (−) or after (+) HSF1-siRNA treatment, in control cells (Ctl), in cell lines expressing the full length HSF1-eGFP (wt), the HSF1-eGFP mutant deleted of ...
Antoine Delon (431449) +7 more
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Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the effect of FBXW7 on the expression and localization of HSF1 in colorectal cancer cells. Methods The expression levels of HSF1 and pHSF1Ser326 protein in FBXW7 deletion (KO) and wild-type (WT) FBXW7-expressing counterpart ...
SUN Ao, JIAO Han, FU Jiejun
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Cell Division, 2021 Background Heat shock factor 1 (HSF1) is the master regulator of the heat shock response and supports malignant cell transformation. Recent work has shown that HSF1 can access the promoters of heat shock proteins (HSPs) and allow HSP expression during ...
Hsiao-Hui Kuo +3 more
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The HSF1-CPT1a Pathway Is Differentially Regulated in NAFLD Progression
Cells, 2022 Obesity and obesity-associated diseases represent one of the key health challenges of our time. In this context, aberrant hepatic lipid accumulation is a central pathological aspect of non-alcoholic fatty liver disease (NAFLD).
Wiebke Breternitz +10 more
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Protein kinase A regulates molecular chaperone transcription and protein aggregation. [PDF]
PLoS ONE, 2011 Heat shock factor 1 (HSF1) regulates one of the major pathways of protein quality control and is essential for deterrence of protein-folding disorders, particularly in neuronal cells.
Yue Zhang +3 more
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Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection. [PDF]
PLoS ONE, 2008 BACKGROUND: Induction of the heat shock response (HSR) and increased expression of the heat shock proteins (HSPs) provide mechanisms to ensure proper protein folding, trafficking, and disposition.
Jingxian Yang +3 more
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Hsf1 down-regulates Hsp90. [PDF]
, 2012 (A) Inhibiting Hsp90 with geldanamycin leads to Hsf1 activation. C. albicans cells were incubated with 20 µM geldanamycin for one hour, and Hsf1 phosphorylation examined by western blotting. (B) Depleting Hsp90 leads to Hsf1 activation.
Carol Munro (108688) +5 more
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HSF1 knockdown inhibits VACV infection. [PDF]
, 2014 Five independent shRNAs targeting HSF1 were used to knockdown protein expression in A549 cells. The levels of HSF1 remaining after selection were quantified by immunoblot with several antibodies. (A) Representative immunoblot (anti-HSF1 J7F9).
Lisa E. Hensley (202167) +12 more
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