The HSF1-CPT1a Pathway Is Differentially Regulated in NAFLD Progression
Cells, 2022 Obesity and obesity-associated diseases represent one of the key health challenges of our time. In this context, aberrant hepatic lipid accumulation is a central pathological aspect of non-alcoholic fatty liver disease (NAFLD).
Wiebke Breternitz +10 more
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Protein kinase A regulates molecular chaperone transcription and protein aggregation. [PDF]
PLoS ONE, 2011 Heat shock factor 1 (HSF1) regulates one of the major pathways of protein quality control and is essential for deterrence of protein-folding disorders, particularly in neuronal cells.
Yue Zhang +3 more
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Molecularchaperones as HSF1-specific transcriptional repressors [PDF]
Genes & Development, 1998 The rapid yet transient transcriptional activation of heat shock genes is mediated by the reversible conversion of HSF1 from an inert negatively regulated monomer to a transcriptionally active DNA-binding trimer. During attenuation of the heat shock response, transcription of heat shock genes returns to basal levels and HSF1 reverts to an inert monomer.
Shi, Yanhong +2 more
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Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection. [PDF]
PLoS ONE, 2008 BACKGROUND: Induction of the heat shock response (HSR) and increased expression of the heat shock proteins (HSPs) provide mechanisms to ensure proper protein folding, trafficking, and disposition.
Jingxian Yang +3 more
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Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]
, 2008 Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano +8 more
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HSF1 Down-regulates XAF1 through Transcriptional Regulation [PDF]
Journal of Biological Chemistry, 2006 Studies have indicated the role of HSF1 (heat-shock transcription factor 1) in repressing the transcription of some nonheat shock genes. XAF1 (XIAP-associated factor 1) was an inhibitor of apoptosis-interacting protein with the effect of antagonizing the cytoprotective role of XIAP.
Lin, MCM +11 more
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Protein kinase A binds and activates heat shock factor 1. [PDF]
PLoS ONE, 2010 Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli.
Ayesha Murshid +5 more
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HSF1 Activation Can Restrict HIV Replication
ACS Infectious Diseases, 2020 Host protein folding stress responses can play important roles in RNA virus replication and evolution. Prior work suggested a complicated interplay between the cytosolic proteostasis stress response, controlled by the transcriptional master regulator heat shock factor 1 (HSF1), and human immunodeficiency virus-1 (HIV-1).
Emmanuel E. Nekongo +5 more
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RSK2 represses HSF1 activation during heat shock [PDF]
Cell Stress & Chaperones, 2000 Heat shock transcription factor 1(HSF1) activation is a multistep process. The conversion of a latent cytoplasmic form to a nuclear, DNA binding state appears to be activated by nonsteroidal anti-inflammatory drugs. In previous studies, we showed that HSF 1 is phosphorylated by the protein kinase RSK2 in vitro and that this effect is inhibited by ...
X, Wang +5 more
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Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals [PDF]
, 2009 Peer reviewedPublisher ...
Brown, Alistair J. P. +3 more
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