Results 21 to 30 of about 948,615 (346)

AIRAP, a New Human Heat Shock Gene Regulated by Heat Shock Factor 1 [PDF]

Journal of Biological Chemistry, 2010
Heat shock factor-1 (HSF1) is the central regulator of heat-induced transcriptional responses leading to rapid expression of molecular chaperones that protect mammalian cells against proteotoxic stress. The main targets for HSF1 are specific promoter elements (HSE) located upstream of heat shock genes encoding a variety of heat shock proteins ...
ROSSI, ANTONELLO, Trotta, E, Brandi, R, Arisi, I, Coccia, M, SANTORO, MARIA GABRIELLA   +5 more
openaire   +6 more sources

Transcription factor cooperativity with heat shock factor 1 [PDF]

Transcription, 2011
The heat shock response has been characterized by the induction of major heat shock proteins that suppress protein aggregation by facilitating protein folding. Recently, we found that mammalian heat shock factor 1, a master regulator of HSP genes, regulates non-HSP genes that suppress protein aggregation by controlling protein degradation in ...
Naoki, Hayashida, Mitsuaki, Fujimoto, Akira, Nakai   +2 more
openaire   +2 more sources

Immunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activator. [PDF]

PLoS Neglected Tropical Diseases, 2014
Schistosomiasis is a chronically debilitating disease caused by parasitic worms of the genus Schistosoma, and it is a global problem affecting over 240 million people.
Kenji Ishida, Melissa Varrecchia, Giselle M Knudsen, Emmitt R Jolly   +3 more
doaj   +1 more source

The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. [PDF]

PLoS ONE, 2013
The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce the
Rachel Raynes, Kathleen M Pombier, Kevin Nguyen, Jessica Brunquell, Jamie E Mendez, Sandy D Westerheide   +5 more
doaj   +1 more source

Temperature, heat shock proteins and growth regulation of the bone tissue

Regulatory Mechanisms in Biosystems, 2022
Ambient heat modulates the elongation of bones in mammals, and the mechanism of such a plasticity has not been studied completely. The influence of heat on growth and development of bone depends on its values.
V. V. Kuibida, P. P. Kohanets, V. V. Lopatynska   +2 more
doaj   +1 more source

Regulatory Mechanisms of Heat Stress Response and Thermomorphogenesis in Plants

Plants, 2022
As worldwide warming intensifies, the average temperature of the earth continues to increase. Temperature is a key factor for the growth and development of all organisms and governs the distribution and seasonal behavior of plants. High temperatures lead
Yunzhuan Zhou, Fuxiang Xu, Yanan Shao, Junna He   +3 more
doaj   +1 more source

Heat shock stimulation of a tilapia heat shock protein 70 promoter is mediated by a distal element [PDF]

, 2001
peer reviewedWe reported previously that a tilapia (Oreochromis mossambicus) heat shock protein 70 (HSP70) promoter is able to confer heat shock response on a reporter gene after transient expression both in cell culture and in microinjected zebrafish ...
Di Martino, Emmanuel, Martial, Joseph, Molina, Alfredo, Muller, Marc   +3 more
core   +2 more sources

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

Science Translational Medicine, 2020
Pharmacological inhibition of a stress-protective transcription factor provides proof of concept for treatment of therapy-resistant cancer. Putting the heat on cancer Heat shock factor 1 is a transcription factor that helps protect healthy cells from ...
Bushu Dong, Alex M. Jaeger, Philip F. Hughes, David R. Loiselle, J. Hauck, Yao Fu, T. Haystead, Jiaoti Huang, D. J. Thiele   +8 more
semanticscholar   +1 more source

The mitogen-activated protein kinase 4-phosphorylated heat shock factor A4A regulates responses to combined salt and heat stresses

Journal of Experimental Botany, 2019
Heat shock factors regulate responses to high temperature, salinity, water deprivation, or heavy metals. Their function in combinations of stresses is, however, not known.
Norbert Andrási, G. Rigó, Laura Zsigmond, Imma Pérez-Salamó, C. Papdi, É. Klement, A. Pettkó-Szandtner, Abu Imran Baba, F. Ayaydin, Ramakrishna Dasari, Á. Cséplő, L. Szabados   +11 more
semanticscholar   +1 more source

Tailoring of Proteostasis Networks with Heat Shock Factors [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
Heat shock factors (HSFs) are the main transcriptional regulators of the heat shock response and indispensable for maintaining cellular proteostasis. HSFs mediate their protective functions through diverse genetic programs, which are composed of genes encoding molecular chaperones and other genes crucial for cell survival.
Jenny, Joutsen, Lea, Sistonen
openaire   +2 more sources