Results 21 to 30 of about 202,314 (262)
A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions. [PDF]
PLoS ONE, 2009 BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown.
Umashankar Singh +2 more
doaj +1 more source
Frontiers in Physiology, 2020 Heat shock proteins are molecular chaperones that are involved in numerous normal cellular processes and stress responses, and heat shock factors are transcriptional activators of heat shock proteins.
Jisu Jin +7 more
doaj +1 more source
Heat Shock Response, Heat Shock Transcription Factor and Cell Aging
Neurosignals, 1996 A characteristic feature of aging is a progressive impairment in the ability to adapt to environmental challenges. The purpose of this article is to review the evidence of an attenuated response to heat and physiological stresses in a number of mammalian aging model systems, including the human diploid fibroblasts in culture, whole animals and animal ...
Y K, Lee, D, Manalo, A Y, Liu
openaire +2 more sources
Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood
Thrombosis Journal, 2007 Background During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients.
Thielmann Matthias +3 more
doaj +1 more source
Journal of Inflammation, 2005 Background Viruses remain one of the inducers of the stress response in the infected cells. Heat shock response induced by vaccinia virus (VV) infection was studied in vitro in human blood monocyte derived macrophages (MDMs) as blood cells usually ...
Dziedzic Jakub +4 more
doaj +1 more source
Manipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression. [PDF]
PLoS ONE, 2010 BACKGROUND: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in the Xenopus tadpole.
Ron P Dirks +4 more
doaj +1 more source
Heat Shock Protein 70 Neutralizes Apoptosis-Inducing Factor
The Scientific World Journal, 2001 Programmed cell death (apoptosis) is the physiological process responsible for the demise of superfluous, aged, damaged, mutated, and ectopic cells.
Guido Kroemer
doaj +1 more source
A model for handling cell stress
eLife, 2016 The heat shock response in yeast is regulated by the interaction between a chaperone protein and a heat shock transcription factor, and fine-tuned by phosphorylation.
Laura Le Breton, Matthias P Mayer
doaj +1 more source
Journal of Pharmacological Sciences, 2013 It is generally accepted that an increase in the myocardial level of heat-shock protein 72 (HSP72) protects viable cardiac tissue against myocardial infarction (MI)-induced stress.
Tetsuro Marunouchi +4 more
doaj +1 more source
FACETS, 2017 Atlantic salmon populations are declining, and warming river temperatures in the summer months are thought to be a significant contributing factor. We describe the time course of cellular and metabolic responses to an ecologically relevant short-term ...
Melanie J. Gallant +3 more
doaj +1 more source