Results 41 to 50 of about 948,615 (346)

Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages

Journal of Inflammation, 2005
Background Viruses remain one of the inducers of the stress response in the infected cells. Heat shock response induced by vaccinia virus (VV) infection was studied in vitro in human blood monocyte derived macrophages (MDMs) as blood cells usually ...
Dziedzic Jakub, Slezak Kinga, Guzik Krzysztof, Kowalczyk Aleksandra, Rokita Hanna   +4 more
doaj   +1 more source

Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci upon Heat Shock

bioRxiv, 2018
Transcriptional induction of Heat Shock Protein (HSP) genes in yeast is accompanied by dynamic changes in their 3D structure and spatial organization, yet the molecular basis for these phenomena remains unknown.
Surabhi Chowdhary, Amoldeep S. Kainth, David Pincus, D. S. Gross   +3 more
semanticscholar   +1 more source

Possible Involvement of HSP90-HSF1 Multichaperone Complex in Impairment of HSP72 Induction in the Failing Heart Following Myocardial Infarction in Rats

Journal of Pharmacological Sciences, 2013
It is generally accepted that an increase in the myocardial level of heat-shock protein 72 (HSP72) protects viable cardiac tissue against myocardial infarction (MI)-induced stress.
Tetsuro Marunouchi, Masato Araki, Mao Murata, Norio Takagi, Kouichi Tanonaka   +4 more
doaj   +1 more source

Transcriptome analysis of Clematis lanuginosa: Novel features of the molecular events occurring under heat-shock stress

Ornamental Plant Research, 2022
The weak heat tolerance of Clematis ornamental varieties negatively affects their ornamental qualities in the summer. To elucidate heat resistance mechanisms, Clematis lanuginosa, which is an important original parent of the Clematis large-flowered group
Linfang Li, Shuan Wang, Qiao Li, Linghe Sun, Xin Han, Lulu Gao, Peng Wang, Fenni Lv, Rutong Yang, Ya Li   +9 more
doaj   +1 more source

Complex Modes of Heat Shock Factor Activation [PDF]

Molecular and Cellular Biology, 1990
Eucaryotic organisms respond to elevated environmental temperatures by rapidly activating the expression of heat shock genes. The transcriptional activation of heat shock genes is mediated by a conserved upstream regulatory sequence, the heat shock element (HSE).
V, Zimarino, C, Tsai, C, Wu
openaire   +2 more sources

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]

, 2008
Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano, Borkowski, Andrew W., Heppner, Frank L., Hutter, Gregor, Jackson, Walter S., King, Oliver D., Lindquist, Susan, Raymond, Gregory J., Steele, Andrew D.   +8 more
core   +3 more sources

The heat shock response and small molecule regulators.

European journal of medicinal chemistry, 2021
The heat shock response (HSR) is a highly conserved cellular pathway that is responsible for stress relief and the refolding of denatured proteins [1].
Margaret K Kurop, Cormac M Huyen, J. H. Kelly, B. Blagg   +3 more
semanticscholar   +1 more source

Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Journal of Inflammation, 2011
Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine ...
Zingarelli Basilia, Gefter Julia V, Sjodin Hanna, Aneja Rajesh K, Delude Russell L   +4 more
doaj   +1 more source

Association of heat shock proteins, heat shock factors and male infertility

Asian Pacific Journal of Reproduction, 2012
It has been well established that heat shock proteins (HSP) and heat shock factors (HSF) are involved in wide varieties of physiological regulation process and signal pathway. Numerous members of heat shock family exhibit a cell-type-specific expression pattern during spermatogenesis and play crucial roles in germ cell development.
Zi-Liang Ji, Yong-Gang Duan, Li-Sha Mou, Jean-Pierre Allam, Gerhard Haidl, Zhi-Ming Cai   +5 more
openaire   +1 more source

Hspb1 inhibits microglial ferroptosis and pro-inflammatory activation to alleviate cerebral ischemia/reperfusion injury in mice

Neural Regeneration Research
Heat shock protein beta-1 may be involved in regulating ferroptosis in cells. The expression of heat shock protein beta-1 is upregulated after stroke; however, the underlying mechanism of action of heat shock protein beta-1 in cerebral ischemia ...
Weilong Hua, Hongye Xu, Rundong Chen, Yiyong Zeng, Lei Zhang, Yongxin Zhang, Xiaoxi Zhang, Yongwei Zhang, Hongjian Zhang, Jianmin Liu, Pengfei Yang   +10 more
doaj   +1 more source