Results 41 to 50 of about 6,066,735 (160)

Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Journal of Inflammation, 2011
Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine ...
Zingarelli Basilia, Gefter Julia V, Sjodin Hanna, Aneja Rajesh K, Delude Russell L   +4 more
doaj   +1 more source

Hspb1 inhibits microglial ferroptosis and pro-inflammatory activation to alleviate cerebral ischemia/reperfusion injury in mice

Neural Regeneration Research
Heat shock protein beta-1 may be involved in regulating ferroptosis in cells. The expression of heat shock protein beta-1 is upregulated after stroke; however, the underlying mechanism of action of heat shock protein beta-1 in cerebral ischemia ...
Weilong Hua, Hongye Xu, Rundong Chen, Yiyong Zeng, Lei Zhang, Yongxin Zhang, Xiaoxi Zhang, Yongwei Zhang, Hongjian Zhang, Jianmin Liu, Pengfei Yang   +10 more
doaj   +1 more source

Hyperthermia increases HSP production in human PDMCs by stimulating ROS formation, p38 MAPK and Akt signaling, and increasing HSF1 activity

Stem Cell Research & Therapy, 2022
Background Human placenta-derived multipotent cells (hPDMCs) are isolated from a source uncomplicated by ethical issues and are ideal for therapeutic applications because of their capacity for multilineage differentiation and proven immunosuppressive ...
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou   +3 more
doaj   +1 more source

I. The Use of a Large Conventional Shock Tube as a Pre-Ionizer for an Inverse Pinch Shock Tube. II. The Application of Thin-Film Heat Transfer Gauges and Flush Electrostatic Probes to Partially Ionized Flows in Shock Tubes [PDF]

, 1967
Part 1. A large diameter (17"), conventional shock tube has been used as the pre-ionizer for an inverse pinch shock tube in an attempt to achieve separation of the shock front and the current sheath in the inverse pinch.
Klein, Alan Frank
core   +1 more source

Differential gene expression studies on HsfA4d, HsfB2a and ClpD1/HSP100 during heat stress in the rice varieties N22 and Co51

Electronic Journal of Plant Breeding, 2020
In the present investigation, differential expression of two transcription factor genes (HsfA4d and HsfB2a) and a heat shock protein (ClpD1/HSP100) was evaluated in the rice varieties N22 and Co 51 using qRT-PCR.
Rishima Maheendran, V. Soundarrajan, N. M. Manikanda Boopathi, R. Gnanam, V. Geethalakshmi and P. Meenakshisundaram
doaj   +1 more source

The role of sigma factor RpoH1 in the pH stress response of Sinorhizobium meliloti [PDF]

, 2010
de Lucena DK, Pühler A, Weidner S. The role of sigma factor RpoH1 in the pH stress response of Sinorhizobium meliloti. BMC Microbiology. 2010;10(1): 256.Background: Environmental pH stress constitutes a limiting factor for S.
Argandoña, Montserrat, Iglesias Guerra, Fernando, Jebbar Mohamed, Reina-Bueno Mercedes, Argandoña Montserrat, Mohamed Jebbar, Mercedes Reina-Bueno, Joaquín J Nieto, Reina Bueno, Mercedes, Argandoña Bertrán, Montserrat, Rodríguez-Moya, Javier, Vargas Macías, Carmen, Iglesias-Guerra Fernando, Jebbar, Mohamed, Nieto Joaquín J, Javier Rodríguez-Moya, Fernando Iglesias-Guerra, Vargas Carmen, de Lucena, Daniella Karine, Reina-Bueno, Mercedes, Rodríguez de Moya Vera, Javier, Pühler, Alfred ; https://orcid.org/, Iglesias-Guerra, Fernando, Weidner, Stefan, Nieto Gutiérrez, Joaquín José, Rodríguez-Moya Javier, Nieto, Joaquín J, Vargas, Carmen, Carmen Vargas, Montserrat Argandoña   +29 more
core   +1 more source

Expression of heat shock protein (Hsp90) paralogues is regulated by amino acids in skeletal muscle of Atlantic salmon [PDF]

, 2013
Heat shock proteins 90 (Hsp90) have an essential role in sarcomere formation and differentiation in skeletal muscle and also act as molecular chaperones during protein folding impacting a wide range of physiological processes.
Daniel Garcia de la Serrana, Johnston Ian A., Ian A. Johnston (39412), Johnston, Ian Alistair, Garcia de la serrana Daniel, Ian A Johnston, Daniel Garcia de la serrana (110372), Garcia de la Serrana Castillo, Daniel   +7 more
core   +1 more source

Absence of ataxin-3 leads to enhanced stress response in C. elegans. [PDF]

PLoS ONE, 2011
Ataxin-3, the protein involved in Machado-Joseph disease, is able to bind ubiquitylated substrates and act as a deubiquitylating enzyme in vitro, and it has been involved in the modulation of protein degradation by the ubiquitin-proteasome pathway.
Ana João Rodrigues, Andreia Neves-Carvalho, Andreia Teixeira-Castro, Anne Rokka, Garry Corthals, Elsa Logarinho, Patrícia Maciel   +6 more
doaj   +1 more source

Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion

Cell Reports, 2020
Summary: Maintenance of protein homeostasis, through inducible expression of molecular chaperones, is essential for cell survival under protein-damaging conditions.
Jenny Joutsen, Alejandro Jose Da Silva, Jens Christian Luoto, Marek Andrzej Budzynski, Anna Serafia Nylund, Aurelie de Thonel, Jean-Paul Concordet, Valérie Mezger, Délara Sabéran-Djoneidi, Eva Henriksson, Lea Sistonen   +10 more
doaj   +1 more source

Discovery of Disubstituted Carboranes as Inhibitors of Heat Shock Protein 90-Heat Shock Factor 1 Interaction. [PDF]

ACS Med Chem Lett
Efficient synthesis of disubstituted para- and ortho-carboranes (2 and 3, respectively) was achieved. Among the compounds synthesized, 3e showed potent suppression of hypoxia-inducible factor 1 (HIF-1) transcriptional activity under hypoxia by a cell ...
Shao Y, Miura K, Asawa Y, Morita T, Li G, Nakamura H.   +5 more
europepmc   +2 more sources