Results 31 to 40 of about 948,615 (346)
HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes
International Journal of Molecular Sciences, 2019 HSF1 (heat shock factor 1) is an evolutionarily conserved master transcriptional regulator of the heat shock response (HSR) in eukaryotic cells. In response to high temperatures, HSF1 upregulates genes encoding molecular chaperones, also called heat ...
D. Kovács +7 more
semanticscholar +1 more source
Heat Shock Response, Heat Shock Transcription Factor and Cell Aging
Neurosignals, 1996 A characteristic feature of aging is a progressive impairment in the ability to adapt to environmental challenges. The purpose of this article is to review the evidence of an attenuated response to heat and physiological stresses in a number of mammalian aging model systems, including the human diploid fibroblasts in culture, whole animals and animal ...
Y K, Lee, D, Manalo, A Y, Liu
openaire +2 more sources
Frontiers in Physiology, 2020 Heat shock proteins are molecular chaperones that are involved in numerous normal cellular processes and stress responses, and heat shock factors are transcriptional activators of heat shock proteins.
Jisu Jin +7 more
doaj +1 more source
A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions. [PDF]
PLoS ONE, 2009 BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown.
Umashankar Singh +2 more
doaj +1 more source
Aneuploidy and proteotoxic stress in cancer [PDF]
, 2015 Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between ...
Donnelly, N., Storchova, Z.
core +2 more sources
FACETS, 2017 Atlantic salmon populations are declining, and warming river temperatures in the summer months are thought to be a significant contributing factor. We describe the time course of cellular and metabolic responses to an ecologically relevant short-term ...
Melanie J. Gallant +3 more
doaj +1 more source
Manipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression. [PDF]
PLoS ONE, 2010 BACKGROUND: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in the Xenopus tadpole.
Ron P Dirks +4 more
doaj +1 more source
Stress response in mesoangioblast stem cells [PDF]
, 2006 Stem cells are presumed to survive various stresses, since they are recruited to areas of tissue damage and regeneration, where inflammatory cytokines and cytotoxic cells may result in severe cell injury.
COSSU G +5 more
core +1 more source
Heat Shock Protein 70 Neutralizes Apoptosis-Inducing Factor
The Scientific World Journal, 2001 Programmed cell death (apoptosis) is the physiological process responsible for the demise of superfluous, aged, damaged, mutated, and ectopic cells.
Guido Kroemer
doaj +1 more source
A model for handling cell stress
eLife, 2016 The heat shock response in yeast is regulated by the interaction between a chaperone protein and a heat shock transcription factor, and fine-tuned by phosphorylation.
Laura Le Breton, Matthias P Mayer
doaj +1 more source