Results 11 to 20 of about 948,615 (346)
The Emerging Role of Heat Shock Factor 1 (HSF1) and Heat Shock Proteins (HSPs) in Ferroptosis [PDF]
Pathophysiology, 2023 Cells employ a well-preserved physiological stress response mechanism, termed the heat shock response, to activate a certain type of molecular chaperone called heat shock proteins (HSPs).
Iman Aolymat +2 more
doaj +2 more sources
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans [PDF]
Aging Cell, 2019 Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose
daeeun jeong +5 more
core +2 more sources
Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response [PDF]
Cell Reports, 2023 Summary: Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts ...
Meng Xu +8 more
doaj +2 more sources
Heat Shock Factor 5 Is Essential for Spermatogenesis in Zebrafish
Cell Reports, 2018 Summary: Heat shock factors (Hsfs) are transcription factors that regulate responses to heat shock and other environmental stimuli. Four heat shock factors (Hsf1-4) have been characterized from vertebrates to date.
Jolly M. Saju +8 more
doaj +2 more sources
Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update [PDF]
Archives of Toxicology, 2012 Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their rapid and abundant induction by stress. HSP genes are activated at the transcriptional level by heat shock transcription factor 1 (HSF1). During the progression of many types of cancer, this heat shock transcriptional regulon becomes co-opted by mechanisms that are
Ciocca, Daniel Ramon +2 more
openaire +4 more sources
Clustering of heat-shock factors [PDF]
Biochemical Journal, 2006 Clusterin is a ubiquitous glycoprotein found in most physiological fluids and tissues. Although not fully understood, the function of clusterin seems to be related to its ability to bind a wide variety of molecules. Since clusterin has been found associated with extracellular protein aggregates, a role as a molecular chaperone has been proposed.
Johanna K, Björk, Lea, Sistonen
openaire +2 more sources
HEAT SHOCK FACTOR A8a Modulates Flavonoid Synthesis and Drought Tolerance1
Plant Physiology, 2020 A heat shock factor mediates flavonoid synthesis and abscisic acid signaling to regulate drought tolerance in apple. Drought is an important environmental factor affecting the growth and production of agricultural crops and fruits worldwide, including ...
Nan Wang +10 more
semanticscholar +1 more source
Nature Communications, 2020 In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC) in patients with inflammatory bowel disease.
Oshrat Levi-Galibov +19 more
semanticscholar +1 more source
Heat Shock-Independent Induction of Multidrug Resistance by Heat Shock Factor 1 [PDF]
Molecular and Cellular Biology, 2006 The screening of two different retroviral cDNA expression libraries to select genes that confer constitutive doxorubicin resistance has in both cases resulted in the isolation of the heat shock factor 1 (HSF1) transcription factor. We show that HSF1 induces a multidrug resistance phenotype that occurs in the absence of heat shock or cellular stress and
Thierry, Tchénio +3 more
openaire +2 more sources
Transient intracellular acidification regulates the core transcriptional heat shock response
eLife, 2020 Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought ...
Catherine G Triandafillou +3 more
doaj +1 more source