Results 11 to 20 of about 202,314 (262)
Molecular Mechanisms of Heat Shock Factors in Cancer
Cells, 2020 Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (
Mikael Christer Puustinen, Lea Sistonen
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Functional diversification of heat shock factors
Biologia Futura, 2022 AbstractHeat shock transcription factors (HSFs) are widely known as master regulators of the heat shock response. In invertebrates, a single heat shock factor, HSF1, is responsible for the maintenance of protein homeostasis. In vertebrates, seven members of the HSF family have been identified, namely HSF1, HSF2, HSF3, HSF4, HSF5, HSFX, and HSFY, of ...
Dániel Kovács +3 more
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Clustering of heat-shock factors [PDF]
Biochemical Journal, 2006 Clusterin is a ubiquitous glycoprotein found in most physiological fluids and tissues. Although not fully understood, the function of clusterin seems to be related to its ability to bind a wide variety of molecules. Since clusterin has been found associated with extracellular protein aggregates, a role as a molecular chaperone has been proposed.
Johanna K, Björk, Lea, Sistonen
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Heat Shock-Independent Induction of Multidrug Resistance by Heat Shock Factor 1 [PDF]
Molecular and Cellular Biology, 2006 The screening of two different retroviral cDNA expression libraries to select genes that confer constitutive doxorubicin resistance has in both cases resulted in the isolation of the heat shock factor 1 (HSF1) transcription factor. We show that HSF1 induces a multidrug resistance phenotype that occurs in the absence of heat shock or cellular stress and
Thierry, Tchénio +3 more
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AIRAP, a New Human Heat Shock Gene Regulated by Heat Shock Factor 1 [PDF]
Journal of Biological Chemistry, 2010 Heat shock factor-1 (HSF1) is the central regulator of heat-induced transcriptional responses leading to rapid expression of molecular chaperones that protect mammalian cells against proteotoxic stress. The main targets for HSF1 are specific promoter elements (HSE) located upstream of heat shock genes encoding a variety of heat shock proteins ...
ROSSI, ANTONELLO +5 more
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Transcription factor cooperativity with heat shock factor 1 [PDF]
Transcription, 2011 The heat shock response has been characterized by the induction of major heat shock proteins that suppress protein aggregation by facilitating protein folding. Recently, we found that mammalian heat shock factor 1, a master regulator of HSP genes, regulates non-HSP genes that suppress protein aggregation by controlling protein degradation in ...
Naoki, Hayashida +2 more
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Temperature, heat shock proteins and growth regulation of the bone tissue
Regulatory Mechanisms in Biosystems, 2022 Ambient heat modulates the elongation of bones in mammals, and the mechanism of such a plasticity has not been studied completely. The influence of heat on growth and development of bone depends on its values.
V. V. Kuibida +2 more
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Regulatory Mechanisms of Heat Stress Response and Thermomorphogenesis in Plants
Plants, 2022 As worldwide warming intensifies, the average temperature of the earth continues to increase. Temperature is a key factor for the growth and development of all organisms and governs the distribution and seasonal behavior of plants. High temperatures lead
Yunzhuan Zhou +3 more
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Regulation of the mammalian heat shock factor 1 [PDF]
The FEBS Journal, 2017 Living organisms are endowed with the capability to tackle various forms of cellular stress due to the presence of molecular chaperone machinery complexes that are ubiquitous throughout the cell. During conditions of proteotoxic stress, the transcription factor heat shock factor 1 (HSF1) mediates the elevation of heat shock proteins, which are crucial ...
Dayalan Naidu, Sharadha +1 more
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Tailoring of Proteostasis Networks with Heat Shock Factors [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 Heat shock factors (HSFs) are the main transcriptional regulators of the heat shock response and indispensable for maintaining cellular proteostasis. HSFs mediate their protective functions through diverse genetic programs, which are composed of genes encoding molecular chaperones and other genes crucial for cell survival.
Jenny, Joutsen, Lea, Sistonen
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