Results 11 to 20 of about 209,087 (308)
Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood
Thrombosis Journal, 2007 Background During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients.
Thielmann Matthias +3 more
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Molecular Mechanisms of Heat Shock Factors in Cancer
Cells, 2020 Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (
Mikael Christer Puustinen, Lea Sistonen
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Journal of Theoretical Biology, 2021 One of the most important questions in cell biology is how cell fate is determined when exposed to extreme stresses such as heat shock. It has been long understood that organisms exposed to high temperature stresses typically protect themselves with a heat shock response (HSR), where accumulation of denatured or unfolded proteins triggers the synthesis
Zhang, M., Zhao, A., Guo, C., Guo, L.
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Functional diversification of heat shock factors
Biologia Futura, 2022 AbstractHeat shock transcription factors (HSFs) are widely known as master regulators of the heat shock response. In invertebrates, a single heat shock factor, HSF1, is responsible for the maintenance of protein homeostasis. In vertebrates, seven members of the HSF family have been identified, namely HSF1, HSF2, HSF3, HSF4, HSF5, HSFX, and HSFY, of ...
Dániel Kovács +3 more
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Heat-Induced Conformational Transition Mechanism of Heat Shock Factor 1 Investigated by Tryptophan Probe. [PDF]
Biochemistry, 2022 A transcriptional regulatory system called heat shock response (HSR) has been developed in eukaryotic cells to maintain proteome homeostasis under various stresses.
Kawagoe S +5 more
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Clustering of heat-shock factors [PDF]
Biochemical Journal, 2006 Clusterin is a ubiquitous glycoprotein found in most physiological fluids and tissues. Although not fully understood, the function of clusterin seems to be related to its ability to bind a wide variety of molecules. Since clusterin has been found associated with extracellular protein aggregates, a role as a molecular chaperone has been proposed.
Johanna K, Björk, Lea, Sistonen
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Heat Shock-Independent Induction of Multidrug Resistance by Heat Shock Factor 1 [PDF]
Molecular and Cellular Biology, 2006 The screening of two different retroviral cDNA expression libraries to select genes that confer constitutive doxorubicin resistance has in both cases resulted in the isolation of the heat shock factor 1 (HSF1) transcription factor. We show that HSF1 induces a multidrug resistance phenotype that occurs in the absence of heat shock or cellular stress and
Thierry, Tchénio +3 more
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AIRAP, a New Human Heat Shock Gene Regulated by Heat Shock Factor 1 [PDF]
Journal of Biological Chemistry, 2010 Heat shock factor-1 (HSF1) is the central regulator of heat-induced transcriptional responses leading to rapid expression of molecular chaperones that protect mammalian cells against proteotoxic stress. The main targets for HSF1 are specific promoter elements (HSE) located upstream of heat shock genes encoding a variety of heat shock proteins ...
ROSSI, ANTONELLO +5 more
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Transcription factor cooperativity with heat shock factor 1 [PDF]
Transcription, 2011 The heat shock response has been characterized by the induction of major heat shock proteins that suppress protein aggregation by facilitating protein folding. Recently, we found that mammalian heat shock factor 1, a master regulator of HSP genes, regulates non-HSP genes that suppress protein aggregation by controlling protein degradation in ...
Naoki, Hayashida +2 more
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The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. [PDF]
PLoS ONE, 2013 The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce the
Rachel Raynes +5 more
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