Results 51 to 60 of about 948,615 (346)
Stem Cell Research & Therapy, 2022 Background Human placenta-derived multipotent cells (hPDMCs) are isolated from a source uncomplicated by ethical issues and are ideal for therapeutic applications because of their capacity for multilineage differentiation and proven immunosuppressive ...
Ju-Fang Liu +3 more
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Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases
Molecular and Cellular Biology, 2016 Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We show here that the dietary agent
S. D. Naidu +14 more
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Hopf bifurcation in a gene regulatory network model: Molecular movement causes oscillations [PDF]
, 2015 Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes.
Chaplain, M, Ptashnyk, M, Sturrock, M
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Differential recognition of heat shock elements by members of the heat shock transcription factor family [PDF]
The FEBS Journal, 2009 Heat shock transcription factor (HSF), an evolutionarily conserved stress response regulator, forms trimers and binds to heat shock element (HSE), comprising at least three continuous inverted repeats of the sequence 5′‐nGAAn‐3′. The single HSF of yeast is also able to bind discontinuously arranged nGAAn units.
Noritaka, Yamamoto +4 more
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Journal of Biological Chemistry, 2018 The long noncoding RNA (lncRNA) NEAT1 (nuclear enriched abundant transcript 1) is the architectural component of nuclear paraspeckles, and it has recently gained considerable attention as it is abnormally expressed in pathological conditions such as ...
Mohammad Lellahi +6 more
semanticscholar +1 more source
Electronic Journal of Plant Breeding, 2020 In the present investigation, differential expression of two transcription factor genes (HsfA4d and HsfB2a) and a heat shock protein (ClpD1/HSP100) was evaluated in the rice varieties N22 and Co 51 using qRT-PCR.
Rishima Maheendran, V. Soundarrajan, N. M. Manikanda Boopathi, R. Gnanam, V. Geethalakshmi and P. Meenakshisundaram
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Absence of ataxin-3 leads to enhanced stress response in C. elegans. [PDF]
PLoS ONE, 2011 Ataxin-3, the protein involved in Machado-Joseph disease, is able to bind ubiquitylated substrates and act as a deubiquitylating enzyme in vitro, and it has been involved in the modulation of protein degradation by the ubiquitin-proteasome pathway.
Ana João Rodrigues +6 more
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Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation [PDF]
, 2013 Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-kappa B-mediated gene expression.
Bahar, Ali A +18 more
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Phosphorylation of Drosophila heat shock transcription factor
Cell Stress & Chaperones, 1999 The role that phosphorylation plays in regulating heat shock factor (HSF) function and activity has been the subject of several studies. Here, we demonstrate that Drosophila melanogaster HSF (DmHSF) is a phosphoprotein that is multiply phosphorylated at some sites and is dephosphorylated at others upon heat shock.
M, Fritsch, C, Wu
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Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1
eLife, 2016 The heat shock response is a universal homeostatic cell autonomous reaction of organisms to cope with adverse environmental conditions. In mammalian cells, this response is mediated by the heat shock transcription factor Hsf1, which is monomeric in ...
Nikolai Hentze +4 more
semanticscholar +1 more source