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Heat shock proteins in infection
Clinica Chimica Acta, 2019Heat shock proteins (HSPs) are constitutively expressed under physiological conditions in most organisms but their expression can significantly enhance in response to four types of stimuli including physical (e.g., radiation or heat shock), chemical and microbial (e.g., pathogenic bacteria, viruses, parasites and fungi) stimuli, and also dietary. These
Azam, Bolhassani, Elnaz, Agi
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Heat Shock Proteins; An Overview
Current Pharmaceutical Biotechnology, 2010Heat shock proteins (Hsps) protect protein substrates against conformational damage to promote the function of the proteins, prevent aggregation and prevent formation of toxic inclusion bodies. Protein aggregates and fibrils have been associated with neurodegenerative diseases and with inclusion bodies.
Lütfi, Tutar, Yusuf, Tutar
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Heat shock proteins and the pancreas
Journal of Cellular Physiology, 2003AbstractHeat shock proteins (HSPs) are cytoprotective molecules that help to maintain the metabolic and structural integrity of cells. In this review, we briefly discuss the regulation and function of HSPs. The review focuses on the current knowledge of pancreatic HSP induction, the HSP level changes during acute pancreatitis, the potential effects of ...
Zoltán, Rakonczay +3 more
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Heat Shock Proteins and Cancer
Trends in Pharmacological Sciences, 2017Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs.
Jian-Ming Wu, Tuoen Liu, Xiukun Lin
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1990
The finding that tumor cells are more thermosensitive than their normal counterparts (1–4) prompted research on the effect of heat on normal and neoplastic cells. In 1970, the phenomenon of thermotolerance was described for the first time (5). Cells of L12l0 leukemia after being exposed to sublethal hyperthermia (52% of BDF1 mice survivors after ...
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The finding that tumor cells are more thermosensitive than their normal counterparts (1–4) prompted research on the effect of heat on normal and neoplastic cells. In 1970, the phenomenon of thermotolerance was described for the first time (5). Cells of L12l0 leukemia after being exposed to sublethal hyperthermia (52% of BDF1 mice survivors after ...
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The stress (heat shock) proteins
International Journal of Biochemistry, 1991When prokaryotic and eukaryotic cells are exposed to a variety of physiological stresses such as a nonlethal temperature (4&43”C) and heavy metals, the synthesis of most proteins is suppressed, but a small number of proteins are rapidly synthesized. This reaction is referred to as the “stress response” or “heat shock response” and the induced proteins ...
H, Itoh, Y, Tashima
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Heat Shock Proteins in Glioblastomas
Neurosurgery Clinics of North America, 2010Glioblastoma multiforme is the most common primary central nervous system tumor. The prognosis for these malignant brain tumors is poor, with a median survival of 14 months and a 5-year survival rate below 2%. Development of novel treatments is essential to improving survival and quality of life for these patients.
Isaac, Yang +2 more
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Heat Shock Proteins and Diabetes
Canadian Journal of Diabetes, 2016Diabetes is a chronic disease, and its prevalence continues to rise and can increase the risk for the progression of microvascular (such as nephropathy, retinopathy and neuropathy) and also macrovascular complications. Diabetes is a condition in which the oxidative stress and inflammation rise.
Marzie, Zilaee, Saeed, Shirali
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Heat shock proteins in immunopathology
Current Biology, 1991In recent years, studies have suggested that autoimmunity and/or immunopathology may sometimes result from the immune response to heat shock proteins of autologous cells and microorganisms. Focusing on the T-cell mediated responses, we review the latest literature on this issue with regard to three hypothetical concepts of immunopathology in which heat
P C, Res, J E, Thole, R R, de Vries
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Heat Shock Proteins and Neuroprotection
2003In response to many metabolic disturbances and injuries including stroke, neurodegenerative disease, epilepsy and trauma, the cell mounts a stress response with induction of a variety of proteins, most notably the 70 kD heat shock protein (Hsp70). The possibility that stress proteins might be neuroprotective was suspected because Hsp70, in particular ...
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